melting phase diagram
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract The phenomena of conglomerate formation-racemic compound formation were investigated in a series of five (N-alkyl)-2′,6′-pipecoloxylidides. The optically active enantiomers were prepared by optical resolution of the racemates using 2R,3R-tartaric acid and 0,0′-dibenzoyl-2R,3R-tartaric acid as resolving agent. By DSC measurement of the racemates and the enantiomer the binary phase diagrams were determined. Among the four racemic molecular compounds the N-methyl derivative is the more stable. By increasing the length of the alkyl chain the stability of the racemic compound decreased, and in case of the longest -butyl-chain conglomerate formation was observed.
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