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  • 1
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Das Protein-Muster von Gehirn, Herz und Skelettmuskel in spätembryonalen und postnatalen Entwicklungsstadien wurde durch Polyacrylamid-Gel-Elektrophorese untersucht. 2. Adultorgane zeigen Spezifität ihrer Eiweißmuster mit Bezug auf relative Anteile und Verteilung der getrennten Eiweißbanden. 3. Die Eiweiß-Zusammensetzung von morphologisch bereits gut definierten Organen im spätembryonalen Stadium wird nicht verändert durch den Vorgang der Geburt und bleibt erhalten bis in die frühe neonatale Periode. 4. Signifikante Entwicklungsänderungen in der Eiweiß-Zusammensetzung, die zur Bildung des adulten Musters führen, finden zwischen dem 3. und 30. postnatalen Tag statt. 5. Die Ergebnisse und die Limitationen der Methode werden beurteilt mit Bezug auf Anwendbarkeit auf entwicklungsbiologische Studien.
    Notes: Summary 1. Protein composition of rat brain, and of heart and skeletal muscle was analysed by polyacrylamide gel electrophoresis in their late fetal and postnatal development. 2. Adult organs show specificity of their protein patterns as judged from the relative quantitative proportions and distribution of separated protein bands. 3. Protein composition of morphologically already well defined organs in the late fetal stage of development is not changed by the event of birth and is preserved unmodified until the early neonatal period. 4. Significant developmental changes in protein composition leading to formation of adult pattern take place between the 3rd and 30th postnatal day. 5. Results and limitations of the technique applied are evaluated from the point of applicability to developmental studies.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4986
    Keywords: gangliosides ; human cerebellum ; Q211 antibody ; c-series gangliosides ; TLC, thin-layer chromatography ; GM3, II3NeuAc-LacCer ; GM2, II3NeuAc-GgOse3Cer ; GM1, II3NeuAc-GgOse4Cer ; GD3, II3(NeuAc)2-LacCer ; GD1a, IV3NeuAc, II3NeuAc-GgOse4Cer ; GD1b, II3(NeuAc)2-GgOse4Cer ; GQ1b, IV3(NeuAc)2II3(NeuAc)2-GgOse4Cer ; GP1c, IV3(NeuAc)2II3(NeuAc)3-GgOse4Cer ; GT1c, II3(NeuAc)3-GgOse4Cer ; GQ1c, IV3NeuAc, II3(NeuAc)3-GgOse4Cer ; GP1c, IV3(NeuAc)2II3(NeuAc)3-GgOse4Cer ; GH1c, IV3(NeuAc)3II3(NeuAc)3-GgOse4Cer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Until now ‘c-series’ polysialogangliosides were known to exist in human brain only during development and in some pathological conditions like Alzheimer’s disease. Using thin-layer chromatography (TLC) and immunostaining with Q211 antibody (TLC-overlay technique) we have analysed ‘c-series’ gangliosides in four human cerebella (age 20, 47, 52 and 54 years). Four distinct ganglioside bands, most probably corresponding to GT1c, GQ1c, GP1c and GH1c were found to exist in the analysed brains, which is convincing demonstration of the existence of ‘c-series’ gangliosides in normal adult human brain. Immunohistochemical analysis was performed to locate polysialogangliosides in the analysed tissue. Q211 antibody was found to bind specifically to a single subpopulation of neurons in the molecular layer of adult cerebellum. According to their position and morphology these cells correspond to stellate neurons. © 1998 Rapid Science Ltd
    Type of Medium: Electronic Resource
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