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  • 1
    Keywords: Canada, Politique sociale. ; Canada, Social policy. ; Chile, Social policy. ; Chili, Politique sociale. ; Ghana, Social policy. ; Ghāna, Politique sociale. ; Développement durable. ; Politique sociale. ; Social policy. ; Sustainable development.
    Notes: Preface / Daniel A. Morales-Gómez -- Ch. 1. Introduction: the paradox of development / Necla Tschirgi -- Ch. 2. Ghana: social-policy reform in Africa / Ernest Aryeetey and Markus Goldstein -- Ch. 3. Chile: progress, problems, and prospects / Dagmar Raczynski -- Ch. 4. Canada: experience and lessons for the future / Terrance Hunsley -- Ch. 5. Conclusion: a research agenda for social-policy reform / Jennifer L. Moher -- Appendix 1: Acronyms and abbreviations -- Appendix 2: Contributing authors -- Bibliography
    Pages: viii, 160, [1] p.
    ISBN: 1-552-50047-0
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  • 2
    Unknown
    Cheltenham, U.K ; Northampton, Mass : Edward Elgar Pub
    Keywords: Electronic books ; Employee motivation, Europe ; Hours of labor, Flexible, Europe ; Incentives in industry, Europe ; Insurance, Unemployment, Europe ; Labor market, Europe ; Labor supply, Europe
    Pages: 1 v. (various pagings)
    ISBN: 1-8454-2562-6
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  • 3
    Keywords: Medical parasitology ; Emerging infectious diseases ; Microbial genetics ; Microbial genomics ; Parasitology ; Infectious Diseases ; Microbial Genetics and Genomics ; Springer eBooks
    Description / Table of Contents: Trypanosoma cruzi Genome Assemblies: Challenges and Milestones of Assembling a Highly Repetitive and Complex Genome -- Mining Trypanosoma cruzi Genome Sequences for Antigen Discovery and Vaccine Development -- Transcriptome Studies in Trypanosoma cruzi using RNAseq -- An Improved Approach to Trypanosoma cruzi Molecular Genotyping by Next-Generation Sequencing of the Mini-Exon Gene -- Genome Editing by CRISPR/Cas9 in Trypanosoma cruzi -- Sample Preparation of Trypanosoma cruzi Surface, Extracellular, and Nuclear Subproteomes -- Isolation and Characterization of Extracellular Vesicles Derived from Trypanosoma cruzi -- Production of Recombinant Trypanosoma cruzi Antigens in Leishmania tarentolae -- Homologous Expression of Glycosylphosphatidyl Inositol-Anchored Glycoproteins in Trypanosoma cruzi -- Metabolic Labeling of Surface Neo-sialylglyconjugates Catalyzed by Trypanosoma cruzi Trans-Sialidase -- Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host: Parasite Interactions -- Transmigration of Trypanosoma cruzi trypomastigotes through 3D Spheroids Mimicking Host Tissues -- In Situ Detection of Dormant Trypanosoma cruzi Amastigotes using Bioluminescent-Fluorescent Reporters -- Multi-Parametric Evaluation of Trypanosoma cruzi Infection Outcome in Animal Models -- MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice -- Genotyping of Trypanosoma cruzi from Clinical Samples by Multilocus Conventional PCR -- Assessing Parasite Load in Chagas Disease Patients by Quantitative Multiplex Real-Time PCR -- Diagnostic Applicability of Neutralizing Antibodies to Trypanosoma cruzi trans-sialidase -- Analytics of Functional Autoantibodies in Patients with Chagas’ Disease -- Apolipoprotein-A1 and Fibronectin Fragments as Markers of Cure for the Chagas Disease -- Host Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma -- Purification of GlycosylphosphatidyLinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of -Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcomes of Chagas Disease -- Cytometric Bead Array (CBA) for Measurement Cytokines Levels in Chagas Disease Patients -- Generation of T. cruzi-specific Primary CD4+ T Cell Lines from Peripheral Blood Mononuclear Cells Isolated from Chagas Disease Patients -- Trypanosma cruzi Specific T-Cell Responses to Monitor Treatment Efficacy in Chronic Chagas Disease -- CD8+ T Cell Response to Trypanosoma cruzi Antigens during Chronic Chagas Disease -- Fluorescence Proteomic Technology to Analyze Peripheral Blood Mononuclear Cells in Chronic Chagas Disease -- Isolation and Phenotypic Characterization of Inflammatory Cells from Clinical Samples: Purification of Macrophages from Trypanosoma cruzi-Infected Hearts
    Abstract: This volume provides detailed descriptions on cutting-edge experimental methods to assess the multiple and complex interactions between T. cruzi and its host. Chapters detail a series of methods and protocols, ranging from rather classical biochemical/genetic approaches to modern, powerful and high-throughput ‘-omics’ technologies, to tackle this issue, as well as novel techniques to improve treatment and clinical evaluation of Chagasic patients. Genome-wide mining strategies aimed at identifying potential parasite antigens and vaccine candidates and an overview on the challenges and milestones encountered during T. cruzi genome assembly are also included. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T. cruzi Infection: Methods and Protocols aims to provide students, researchers, and clinicians who are interested in the study of Chagas disease an indispensable source of information
    Pages: XVII, 398 p. 60 illus., 47 illus. in color. : online resource.
    ISBN: 9781493991488
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  • 4
    Keywords: Medicine ; Neurosciences ; Neurology ; Artificial intelligence ; Algebra ; Applied psychology ; Biomedicine ; Neurosciences ; Category Theory, Homological Algebra ; Philosophy ; Neurology ; Artificial Intelligence (incl. Robotics) ; Biological Psychology ; Springer eBooks
    Description / Table of Contents: Preface -- Research tools and paradigms -- State of the Art: Mathematical approaches in brain science -- The Categorical Imperative: Category theory in Cognitive and Brain Science -- Elementary principles in cognitive systems modeling -- The shift towards structure -- A general framework for representation -- Towards a Theory of Brain Structure and Function -- A theory of hippocampus structure and function based on Category Theory -- From Cells to Memories. A Categorical Approach -- Epilogue
    Abstract: The purpose of the book is to advance in the understanding of brain function by defining a general framework for representation based on category theory. The idea is to bring this mathematical formalism into the domain of neural representation of physical spaces, setting the basis for a theory of mental representation, able to relate empirical findings, uniting them into a sound theoretical corpus. The innovative approach presented in the book provides a horizon of interdisciplinary collaboration that aims to set up a common agenda that synthesizes mathematical formalization and empirical procedures in a systemic way. Category theory has been successfully applied to qualitative analysis, mainly in theoretical computer science to deal with programming language semantics. Nevertheless, the potential of category theoretic tools for quantitative analysis of networks has not been tackled so far. Statistical methods to investigate graph structure typically rely on network parameters. Category theory can be seen as an abstraction of graph theory. Thus, new categorical properties can be added into network analysis and graph theoretic constructs can be accordingly extended in more fundamental basis. By generalizing networks using category theory we can address questions and elaborate answers in a more fundamental way without waiving graph theoretic tools. The vital issue is to establish a new framework for quantitative analysis of networks using the theory of categories, in which computational neuroscientists and network theorists may tackle in more efficient ways the dynamics of brain cognitive networks. The intended audience of the book is researchers who wish to explore thevalidity of mathematical principles in the understanding of cognitive systems. All the actors in cognitive science: philosophers, engineers, neurobiologists, cognitive psychologists, computer scientists etc. are akin to discover along its pages new unforeseen connections through the development of concepts and formal theories described in the book. Practitioners of both pure and applied mathematics e.g., network theorists, will be delighted with the mapping of abstract mathematical concepts in the terra incognita of cognition
    Pages: XXIII, 193 p. 73 illus., 40 illus. in color. : online resource.
    ISBN: 9789400777385
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  • 5
    Keywords: Life sciences ; Bioinformatics ; Life sciences ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: Actigraphy Pattern Analysis For Outpatient Monitoring -- Definition of Loss Functions for Learning from Imbalanced Data to Minimize Evaluation Metrics -- Audit Method Suited for DSS in Clinical Environment -- Incremental Logistic Regression for Customizing Automatic Diagnostic Models -- Using Process Mining for Automatic Support of clinical Pathways Design -- Analyzing Complex Patients' Temporal Histories: New Frontiers in Temporal Data Mining -- The Snow System – A Decentralized Medical Data Processing System -- Data Mining for Pulsing the Emotion on the Web -- Introduction on Health Recommender Systems -- Cloud Computing for Context-Aware Enhanced m-Health Services -- Analysis of Speech-based Measures for Detecting and Monitoring Alzheimer`s Disease -- Applying Data Mining for the Analysis of Breast Cancer Data -- Mining Data When Technology Is Applied To Support Patients and Professional On The Control Of Chronic Diseases: The Experience Of The METABO Platform For Diabetes Management -- Data Analysis In Cardiac Arrhythmias -- Knowledge-Based Personal Health System to Empower Outpatients of Diabetes Mellitus by means of P4 Medicine -- Serious Games For Elderly Continuous Monitoring
    Abstract: This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical,℗ Data Mining in Clinical Medicine seeks to aid scientists with℗ new approaches and trends in the field
    Pages: XII, 270 p. 92 illus., 82 illus. in color. : online resource.
    ISBN: 9781493919857
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  • 6
    Keywords: Medicine ; Biochemistry ; Molecular Medicine ; Medical Biochemistry ; Springer eBooks
    Description / Table of Contents: Chapter 1: Bases of the inflammasomes in the clinical practice. A brief introduction -- Chapter 2: The Inflammasomes in Cardiovascular Disease -- Chapter 3: Inflammasomes in CNS diseases -- Chapter 4: Lung Diseases -- Chapter 5: Traumatic Injury -- Chapter 6: Inflammasome in the pathogenesis of pulmonary diseases -- Chapter 7: Inflammasome and Oral Diseases -- Chapter 8: Inflammasomes in the kidney -- Chapter 9: Pro-inflammatory actions of red blood cell-derived DAMPs -- Chapter 10: Role of Inflammasomes in the Development of Gastrointestinal Diseases -- Chapter 11: Inflammasomes in bone diseases -- Chapter 12: Inflammasome in Cancer -- Chapter 13: Aging and the inflammasomes -- Chapter 14: Genetics of inflammasome -- Chapter 15: Therapeutic implications of the inflammasomes
    Abstract: This volume focuses on the role of inflammasomes in a variety of diseases and their therapeutic options. It gives an overview of the current studies elucidating the molecular implications in the medical and clinical contexts. It covers inflammasomes as potential therapeutic targets and evaluates the benefits of inflammasome inhibitors
    Pages: VIII, 400 p. 63 illus., 26 illus. in color. : online resource.
    ISBN: 9783319893907
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  • 7
    Keywords: Evolution (Biology) ; Physical anthropology ; Morphology (Animals) ; Developmental Biology ; Vertebrates ; Evolutionary Biology ; Biological and Physical Anthropology ; Animal Anatomy / Morphology / Histology ; Developmental Biology ; Vertebrates ; Springer eBooks
    Description / Table of Contents: 0 Yoel Rak. Introduction -- Hominoids -- 1 Gabrielle E. Russo, Cranial base in Hominoids in relation to posture and locomotion -- 2 Thierra K. Nalley, Neysa Grider-Potter, Mikel Arlegi, Vertebral morphology in hominoids, posture and locomotion: I-the cervical spine -- 3 Liza Shapiro, Vertebral morphology in hominoids, posture and locomotion: II-the thoracic and the lumbar spine -- 4 Masato Nakatsukasa, The spinal plasticity: changes in spinal morphology due to locomotor changes: the example of Japanese macaques -- Modern humans -- 5 Jeannie Bailey, Patricia Kramer, Lumbar lordosis and motion: implications for fossil hominins -- 6 Eric Castillo, Dan Lieberman, Biomechanical models of the spine, evolutionary perspective -- 7 Leonid Kalichman, Ella Been, Spinal posture and spinal pathology in modern humans -- 8 Katherine Whitcome, Sexual dimorphism of the axial skeleton -- 9 Sandra Martelli, Spinal ontogeny and evolution -- Methodology -- 10 Ella Been, Reconstruction of the spinal curvatures based on skeletal material -- 11 Markus Bastir, The use of geometric morphometrics in the study of the human spine -- 12 Kate Robson Brown, Infant vertebral cancellous bone ontogeny (Neanderthals and modern humans) -- 13 Patricia Kramer, Finite Element Analysis of the vertebral spine- implications to human evolution -- Extinct hominins -- 14 Scott Williams, The spine of Australopith -- 15 Marc Meyer, The spine of Early Homo -- 16 Asier Gómez-Olivencia, Ella Been, The spine of Late Homo -- 17 Martin Haeusler, Spinal paleopathology in hominins -- Final chapter, Been et al., Future perspectives into the study of the human spine and its evolution
    Abstract: The vertebral spine is a key element of the human anatomy. Its main role is to protect the spinal cord and the main blood vessels. The axial skeleton, with its muscles and joints, provides stability for the attachment of the head, tail and limbs and, at the same time, enables the mobility required for breathing and for locomotion. Despite its great importance, the vertebral spine is often over looked by researchers because: a) vertebrae are fragile in nature, which makes their fossilization a rare event; b) they are metameric (seriated and repeated elements) that make their anatomical determination and, thus, their subsequent study difficult; and c) the plethora of bones and joints involved in every movement or function of the axial skeleton makes the reconstruction of posture, breathing mechanics and locomotion extremely difficult. It is well established that the spine has changed dramatically during human evolution. Spinal curvatures, spinal load transmission, and thoracic shape of bipedal humans are derived among hominoids. Yet, there are many debates as to how and when these changes occurred and to their phylogenetic, functional, and pathological implications. In recent years, renewed interest arose in the axial skeleton. New and exciting finds, mostly from Europe and Africa, as well as new methods for reconstructing the spine, have been introduced to the research community. New methodologies such as Finite Element Analysis, trabecular bone analysis, Geometric Morphometric analysis, and gait analysis have been applied to the spines of primates and humans. These provide a new and refreshing look into the evolution of the spine. Advanced biomechanical research regarding posture, range of motion, stability, and attenuation of the human spine has interesting evolutionary implications. Until now, no book that summarizes the updated research and knowledge regarding spinal evolution in hominoids has been available. The present book explores both these new methodologies and new data, including recent fossil, morphological, biomechanical, and theoretical advances regarding vertebral column evolution. In order to cover all of that data, we divide the book into four parts: 1) the spine of hominoids; 2) the vertebral spine of extinct hominins; 3) ontogeny, biomechanics and pathology of the human spine; and 4) new methodologies of spinal research. These parts complement each other and provide a wide and comprehensive examination of spinal evolution
    Pages: X, 407 p. 86 illus., 62 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030193492
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  • 8
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Acute leukemia ; CFU-GM ; Granulocyte compartment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The possible interrelation between infused bone marrow CFU-GM and peripheral granulocyte recovery was studied in 16 patients transplanted for acute leukemia. The influence of several clinical events that could modify the graft fate were also analysed. Our results show that: 1) There was no correlation between the number of infused nucleated cells and granulocyte recovery. 2) There was no correlation between the number of infused CFU-GM and granulocyte regeneration. 3) There were significant differences between the day of engraftment in patients with clinically documented HSV infection compared to patients without infection.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The evidences that p16 and cyclin D alterations occur in the earlier stages of many human cancers and that its immunolocalization can be used to study the cell cycle regulation, coupled with the possibility that chronic use of carbamide peroxide would induce DNA damage and cell cycle alteration, prompted us to analyse the effect of carbamide peroxide on the immunolocalization of these proteins in rat oral mucosa. Ten male Wistar rats were selected and submitted to topical application of 35% carbamide peroxide over buccal mucosa. The procedures were carried out twice a week for 3 months consecutively. The animals were killed after the last treatment and the buccal mucosa was removed and stored at −70 °C. Only distilled water was applied over the buccal mucosa of the control animals. The biotin–streptavidin amplified system was used for identification of cyclin D and p16 antigens and the percentage of basal and suprabasal cells positive for each one were obtained. The results did not show any difference between the experimental and control groups regarding the immunolocalization of cyclin D and p16. In conclusion, the present study showed that chronic use of carbamide peroxide does not induce cell cycle alteration in the oral mucosa of rats.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The structure and ultrastructure of the adenohypophyseal pars distalis in kids of the Murciano-granadiana breed (18 males and 12 females), aged 2–3 months and with an average carcass weight of 8 kg has been studied.Techniques of staining (Tetrachrome Herlant's, and Cleveland-Wolfe) and histochemistry (PAS, PAS-OG and BA-PAS-OG) contrasted with immunolabelling (PAP) have been used. In addition an ultrastructural study has been made and nucleus and cytoplasm, secretory granules, mitochondria and lysosomes have been measured with a semiautomatic image analyzer (IBAS-1).TSH cells are found in sagittal section in the anterior area and in an antero-caudodorsal band, and transversally in the ventral and medial region; they are 6% and their average size is 14.15 um. Ultrastructurally they are a single cellular type with spherical granules whose size is 195nm in males and 149 in females; these granules are characterized by a clear halo and a variable electronic density. The rough endoplasmic reticulum is found as slightly enlarged vesicles with a homogeneous and moderately electrodense content or in concentric stratifications.
    Type of Medium: Electronic Resource
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