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  • 1
    Unknown
    Hershey PA : Idea Group Pub
    Keywords: ASDA (Group) ; Electronic commerce, Great Britain. ; Grocery trade, Technological innovations, Great Britain. ; Grocery trade, Great Britain, Management. ; Internet marketing, Great Britain.
    ISBN: 1-417-58264-2
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  • 2
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    Burlington, Mass : Elsevier Butterworth-Heinemann
    Keywords: Materials, Fatigue, Testing. ; Strains and stresses, Testing.
    Pages: xiv, 402 p.
    ISBN: 1-417-54444-9
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  • 3
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    Hershey PA : Idea Group Pub
    Keywords: Electronic commerce. ; Electronic data interchange.
    ISBN: 1-591-40383-9
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  • 4
    Keywords: Cognitive styles. ; Human information processing. ; Learning, Psychology of. ; Thought and thinking.
    Pages: x, 276 p.
    ISBN: 0-585-36394-3
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  • 5
    Unknown
    East Lansing, Mich : Michigan State University
    Keywords: Rural development, Sociological aspects, Cross-cultural studies. ; Rural population, Cross-cultural studies. ; Rural population, United States. ; Sociology, Rural. ; Sociology, Rural, Research.
    Notes: The poor in nonmetropolitan America / William P. O'Hare -- Mechanization in the western Upper Peninsula pulp-logging industry / Jon H. Rieger -- Development, women's work, and economic inequality in rural Taiwan / Rita S. Gallin -- Inequality and the emergence of nonfarm employment in Rwanda / Daniel C. Clay, Theobald Kampayana, and Jean Kayitsinga -- Social and economic transformation in a Greek farming village / George A. Daoutopoulos -- Recent population change in Michigan's metropolitan and nonmetropolitan areas / Ching-li Wang -- The transmission of information regarding population change in a rural county / Richard W. Rathge -- Fatal farm accidents in Michigan : implications for research and policy / Nan E. Johnson -- Irish rural-urban migration: post-1960 changes / Damian F. Hannan -- Changing rural communities : reconstructing the local economy of a nonmetropolitan community / Marilyn W. Aronoff -- Social change and dress among the Kalabari of Nigeria / Joanne Bubolz Eicher -- The call of the sugar cane : agricultural change, cooperative-capitalism, and migrants in northwestern Uruguay / Gaston J. Labadie
    Pages: x, 255 p.
    ISBN: 0-585-20090-4
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  • 6
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: 1 Bioequivalence History -- 2 Fundamentals of Bioequivalence -- 3 Basic Statistical Considerations -- 4 The Effects of Food on Drug Bioavailability and Bioequivalence -- 5 Bio waiver and Biopharmaceutics Classification System -- 6 Bioequivalence of Highly Variable Drugs -- 7 Partial Area under the Curve: An Additional Pharmacokinetic Metric for Bioavailability and Bioequivalence Assessments -- 8 Bioequivalence for Narrow Therapeutic Index Drugs -- 9 Pharmacodynamic Endpoint-based Bioequivalence Studies -- 10 Clinical Endpoint Bioequivalence Study -- 11 Bioequivalence for Liposomal Drug Products -- 12 Bioequivalence for Drug Products Acting Locally within Gastrointestinal Tract -- 13 Bioequivalence for Topical Drug Products -- 14 Bioequivalence for Orally Inhaled and Nasal Drug Products -- 15 Bioequivalence: Modeling and Simulation -- 16 Bioanalysis
    Abstract: This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation, and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products, and nasal and inhalation products. FDA Bioequivalence Standards is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies, and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards
    Pages: XIII, 465 p. 58 illus., 26 illus. in color. : online resource.
    ISBN: 9781493912520
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  • 7
    Keywords: Medicine ; Medical records / Data processing ; Medicine & Public Health ; Medicine/Public Health, general ; Health Promotion and Disease Prevention ; Health Informatics ; Springer eBooks
    ISBN: 9781461415992
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  • 8
    Keywords: Bacteriology ; Drug Interactions ; Bacteriology ; Pharmacotherapy ; Drug Resistance ; Springer eBooks
    Description / Table of Contents: Overview -- Multidrug resistant Gram-negative pathogens: the urgent need for €˜óld́€™ polymyxins -- Discovery, antibacterial spectrum and chemistry -- Mechanisms of antibacterial activity -- Mechanisms of resistance -- Bioanalysis and stability of polymyxins -- In vitro pharmacodynamics and PK/PD in animals -- Antibacterial susceptibility breakpoints -- Labeling of parenteral products of colistin methanesulfonate -- Meta-analysis of polymyxin use in patients -- Clinical use of colistin -- Clinical use of polymyxin B -- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations -- Rational combinations with other antibiotics -- Toxicities in patients: management and mechanisms -- Antiendotoxin effect -- Discovery of novel polymyxin-like antibiotics -- Conclusion
    Abstract: This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’
    Pages: VIII, 366 p. 89 illus., 44 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030163730
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  • 9
    Unknown
    New York, NY : Springer
    Keywords: Neurosciences ; Proteomics ; Neurosciences ; Proteomics ; Springer eBooks
    Description / Table of Contents: Neuroproteomics: The Methods -- Dissection of Rodent Brain Regions: Guided Free-Hand Slicing and Dissection of Frozen Tissue -- Isolation of Synapse Sub-Domains by Subcellular Fractionation Using Sucrose Density Gradient Centrifugation: Purification of the Synaptosome, Synaptic Plasma Membrane, Postsynaptic Density, Synaptic Membrane Raft, and Postsynaptic Density Lattice -- Laser Microdissection for Spatial Proteomics of Post Mortem Brain Tissue -- High pH Reversed-Phase Pre-Fractionation for In-Depth Shotgun Proteomics -- Sample Preparation for Proteomics Analysis: Filter-Aided Sample Preparation (FASP) and Single-Pot Solid-Phase Sample Preparation (SP3) -- Enrichment of Low-Molecular-Weight Phosphorylated Biomolecules Using Phos-Tag Tip -- Integrated Immunoprecipitation: Blue Native Gel Electrophoresis - Mass Spectrometry for the Identification of Protein Sub-Complexes -- Analysis of Synaptic Protein-Protein Interaction by Crosslinking-Mass Spectrometry -- TMT-MS3 Enabled Proteomic Quantification of Human IPSC Derived Neurons -- Data Independent Acquisition (SWATH) Mass Spectrometry Analysis of Protein Content in Primary Neuronal Cultures -- Quantitative Analysis of Mass Spectrometry-Based Proteomics Data -- 2D-DIGE as a Tool in Neuroproteomics -- Neuropeptidomics of the Mammalian Brain -- MALDI Imaging Mass Spectrometry - Neurochemical Imaging of Proteins and Peptides -- A Combined Cellomics and Proteomics Approach to Uncover Neuronal Pathways to Psychiatric Disorder
    Abstract: This second edition volume expands on the previous edition with updates on the latest techniques used in the field of proteomics. Tissue and cellular proteins are now being analyzed at near proteome-wide levels and mass spectrometers are achieving higher sensitivity and speed, resolution, and accuracy. The chapters in this book cover various new methods used in proteomic workflows such as laser microdissection for spatial proteomics of post-mortem brain tissue, sample preparation in single vessel with FASP and SP3 protocols, the crosslinking mass spectrometry, TMT-MS3 based proteomic with synchronous precursor selection, mass spectrometric data dependent acquisition (DDA) and data independent acquisition (DIA, SWATH) methods, 2D-DIGE, and MALDI Imaging Mass Spectrometry. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neuroproteomics, Second Edition is a valuable guide that help researchers obtain the finest results from current proteomics platforms
    Pages: XIII, 218 p. 55 illus., 37 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493996629
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  • 10
    Keywords: Physics ; Biochemical engineering ; Microreactors ; Engineering ; Physics ; Fluid- and Aerodynamics ; Microengineering ; Engineering Thermodynamics, Heat and Mass Transfer ; Biochemical engineering ; Springer eBooks
    Pages: : digital
    ISBN: 9789048190294
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