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1 streaming video file (30 min.) :
digital, mono., SWF file, sd., col.
Cell division cycle : controlling when and where cells divide and differentiate
Contents: Somatic cell cycle -- Rb pathway -- Positive regulation of G1 phase by phosphorylation of the retinoblastoma protein (Rb) by cyclin-dependent kinases (Cdks) -- Negative regulation of G1 by Cdk-inhibitory proteins (CKIs) -- Rb pathway is often disrupted in cancers -- Two families of CKIs, differential expression in embryogenesis and adult mouse tissues -- Loss of p18Ink4c and p19ink4d induces male sterility -- Loss of p19Ink4d induces progressive deafness after birth -- Loss of p19Ink4d and p27Kip1 induces re-entry of differentiated postmitotic neurons in cycle after birth -- Loss of Ink4c and Patched or p53 induces medulloblastoma, a pediatric tumor of the cerebellum -- CKIs are required for exit from and maintenance of cell cycle exit, or quiescence, a reversible state -- Loss of CKIs leads to sterility, deafness and cancers.
Mode of access: World Wide Web.