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  • 1
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    Totowa, NJ : Springer Science+Business Media, LLC
    Keywords: Medicine ; Biotechnology ; Surgery ; Cytology ; Biomaterials ; Medicine & Public Health ; Surgery ; Biomaterials ; Cell Biology ; Biotechnology ; Springer eBooks
    Pages: : digital
    Edition: 2012.
    ISBN: 9781617795701
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  • 2
    Keywords: Life sciences ; Human Physiology ; Medicine ; Biochemistry ; Cytology ; Life sciences ; Biochemistry, general ; Cell Biology ; Human Physiology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: PART I BIOSYNTHESIS OF POLYAMINES,- 1 Biosynthesis of Polyamines in Eukaryotes, Archaea, and Bacteria -- 2 Long-Chain and Branched Polyamines in Thermophilic Microbes -- 3 Regulation and Diversity of Polyamine Biosynthesis in Plants -- PART II CATABOLISM OF POLYAMINES -- 4 Polyamine Catabolism in Prokaryotes -- 5 Mammalian Polyamine Catabolism -- 6 Polyamine Catabolism in Plants -- PART III POLYAMINE HOMEOSTASIS -- 7 Antizyme -- 8 Bacterial Antizyme -- 9 Polyamine Homeostasis in Plants: The Role(s) of Evolutionarily Conserved Upstream ORFs -- PART IV ROLES OF POLYAMINES IN GROWTH -- 10 Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A -- 11 The Polyamine Modulon: Genes Encoding Proteins Whose Synthesis Is Enhanced by Polyamines at the Level of Translation -- 12 Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression -- PART V ROLES OF POLYAMINES IN SURVIVAL -- 13 Polyamines in Plant Stress Response -- PART VI POLYAMINE TRANSPORTERS -- 14 Recent Advances in Bacterial Polyamine Transport Systems -- 15 Polyamine Transport Systems in Plants -- PART VII POLYAMINE-DERIVED SECONDARY METABOLITES -- 16 Polyamine-Derived Alkaloids in Plants: Molecular Elucidation of Biosynthesis -- 17 Polyamine Toxins from Spiders and Wasps -- PART VIII ACTION OF POLYAMINES ON ION CHANNELS -- 18 Polyamine Block of Inwardly Rectifying Potassium (Kir) Channels -- 19 Polyamine Action on Plant Ion Channels and Pumps -- 20 Regulation of N-Methyl-d-Aspartate Receptors by Spermine and Ifenprodil -- PART IX POLYAMINES AND LONGEVITY -- 21 Polyamines and Longevity in Mammals -- 22 Polyamine Interactions with Plant Hormones: Crosstalk at Several Levels -- PART X DIAGNOSIS AND DRUG TARGETS -- 23 N1, N12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion -- 24 Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa
    Abstract: This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers
    Pages: IX, 336 p. 66 illus., 28 illus. in color. : online resource.
    ISBN: 9784431552123
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  • 3
    Keywords: Human Genetics ; Bioinformatics ; Human Genetics ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: Chapter1. Strategies for converting RNA to amplifiable cDNA for single-cell RNA sequencing methods -- Chapter2. Integrated Fluidic Circuits for single cell omics and multi-omics applications -- Chapter3. Single-cell DNA-Seq and RNA-Seq in cancer using the C1 system -- Chapter4. Nx1-Seq (Well based Single-Cell Analysis System) -- Chapter5. Quantitation of mRNA transcripts and proteins using the BD Rhapsody™ Single-Cell Analysis System -- Chapter6. An Informative Approach to Single-Cell Sequencing Analysis -- Chapter7. Bionano Genome Mapping: High-Throughput, Ultra-Long Molecule Genome Analysis System for Precision Genome Assembly and Haploid-Resolved Structural Variation Discovery -- Chapter8. Informatics for PacBio long reads -- Chapter10. On-site MinION sequencing
    Abstract: This book presents an overview of the recent technologies in single molecule and single cell sequencing. These sequencing technologies are revolutionizing the way of the genomic studies and the understanding of complex biological systems. The PacBio sequencer has enabled extremely long-read sequencing and the MinION sequencer has made the sequencing possible in developing countries. New developments and technologies are constantly emerging, which will further expand sequencing applications. In parallel, single cell sequencing technologies are rapidly becoming a popular platform. This volume presents not only an updated overview of these technologies, but also of the related developments in bioinformatics. Without powerful bioinformatics software, where rapid progress is taking place, these new technologies will not realize their full potential. All the contributors to this volume have been involved in the development of these technologies and software and have also made significant progress on their applications. This book is intended to be of interest to a wide audience ranging from genome researchers to basic molecular biologists and clinicians
    Pages: VI, 150 p. 56 illus., 51 illus. in color. : online resource.
    ISBN: 9789811360374
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  • 4
    Keywords: Dentistry ; Microbiology ; Surgery ; Materials ; Biomaterials ; Dentistry ; Dentistry ; Oral and Maxillofacial Surgery ; Biomaterials ; Medical Microbiology ; Materials Science, general ; Springer eBooks
    ISBN: 9784431540700
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  • 5
    Keywords: Dentistry ; Biomaterials ; Dentistry ; Springer eBooks
    Pages: : digital
    ISBN: 9784431996446
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  • 6
    Keywords: Life sciences ; Cancer Research ; Human Physiology ; Neurosciences ; Biochemistry ; Cell Biology ; Developmental Biology ; Life sciences ; Cell Biology ; Developmental Biology ; Human Physiology ; Animal Biochemistry ; Neurosciences ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Foreword -- Preface -- Part I Overview -- 1 Introduction -- 2 Evolution of Cadherins and Associated Catenins -- Part II Classical Cadherins -- 3 Classical Cadherins -- 4 Structure and Function of Cadherin Extracellular Regions -- 5 Regulation of Cadherin-Catenin Biology by Mechanical Force and Phosphorylation -- 6 Cooperative Roles of Nectins with Cadherins in Physiological and Pathological Processes -- Part III Atypical Cadherins -- 7 Desmosomal Cadherins -- 8 Clustered Protocadherins -- 9 The Non-clustered Protocadherins -- 10 Seven-Pass Transmembrane Cadherin CELSRs, and Fat4 and Dchs1 Cadherins: From Planar Cell Polarity to Three-Dimensional Organ Architecture -- 11 Various Atypical Cadherins: T-Cadherin, RET, Calsyntenin, and 7-D Cadherin -- Part IV Cadherins in Tissues and Diseases -- 12 Cadherins in Neural Development -- 13 Cadherins in the Auditory Sensory Organ -- 14 Cadherins in Cancer -- 15 Cadherin-Related Diseases -- BM Index
    Abstract: This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases
    Pages: XII, 428 p. 76 illus., 74 illus. in color. : online resource.
    ISBN: 9784431560333
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  • 7
    Keywords: Life sciences ; Oncology ; Immunology ; Biochemistry ; Life sciences ; Biochemistry, general ; Cancer Research ; Immunology ; Springer eBooks
    Description / Table of Contents: 1 N-Glycans and Quality Control of Proteins -- 2 Glycan-Mediated Protein Transport from the Endoplasmic Reticulum -- 3 Gangliosides and T-Cell Immunity -- 4 Gangliosides Regulate Tumor Properties: With Focus on the Suppression of Metastasis-Associated ppGalNAc-T13 with GM1 -- 5 Role of Glycans in Viral Infection -- 6 Discovery and Applications of a Novel Human Pluripotent Stem Cell-Specific Lectin Probe rBC2LCN -- 7 Glycan Structure and Neural Plasticity -- 8 The Involvement of Midkine, a Heparin-Binding Growth Factor, in Cancer Development -- 9 Tumor-Associated Glycans and Their Functional Roles in the Multistep Process of Human Cancer Progression -- 10 Mammalian Sialidase and Tumor Development -- 11 Roles of Glycans in Immune Evasion from NK Immunity -- 12 Glycomic Analysis of Cancer -- 13 Glyco-Predisposing Factor of Diabetes -- 14 Macrophages Govern Ganglioside GM3 Expression in Adipocytes to Regulate Adipogenesis and Insulin Signaling in Homeostatic and Pathogenic Conditions -- 15 O-Mannosyl Glycan and Muscular Dystrophy -- 16 Glycans and Chronic Obstructive Pulmonary Disease (COPD) -- 17 α1,6-Fucosyltransferase Knockout Mice and Schizophrenia-Like Phenotype
    Abstract: This book presents the latest breakthrough results in glycobiology regarding the roles of glycans in relation to quality control and transport of protein, the immune system, viral infection, stem cells, the neural system, and various diseases such as cancer, diabetes, chronic obstructive pulmonary disease, muscular dystrophy, and schizophrenia. Although glycoscience has long been regarded as a very specialized field with no simple analytical method, the recent explosive progress in research continues to provide limitless evidence that glycan chains are the key component in various biological phenomena. Cell surface glycans, for example, change with developmental stages or environmental conditions and thus represent a “face” of the cell that is utilized for identification of iPS and ES cells and as biomarkers in diagnosis or detection of cancer. This book comprises 17 chapters, each of which poses outstanding “glyco-related” questions enabling non-specialists to have a clearer idea about what the future direction for further investigation of glycans in their own research fields will be. Also including basic information to understand the nature of glycans, this title serves as an excellent “textbook” for researchers in diverse research fields who are not familiar with, but nevertheless interested in, glycan chains or sugar chains
    Pages: VIII, 288 p. 87 illus., 41 illus. in color. : online resource.
    ISBN: 9784431553816
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  • 8
    Keywords: CDNA ; CLONES ; BIOLOGY ; alternative splicing ; CDNAS ; ASSEMBLIES ; assembly ; ANNOTATION ; COMPLETE GENOM
    Abstract: The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for nonprotein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology
    Type of Publication: Journal article published
    PubMed ID: 15103394
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  • 9
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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