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  • 1
    Publication Date: 2018-04-07
    Description: IJERPH, Vol. 15, Pages 693: Low Levels of Knowledge, Attitudes and Preventive Practices on Leptospirosis among a Rural Community in Hulu Langat District, Selangor, Malaysia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15040693 Authors: Noramira Nozmi Suhailah Samsudin Surianti Sukeri Mohd Shafei Wan Wan Mohd Zawaha Idris Wan Arifin Norazlin Idris Siti Saudi Nurul Abdullah Zainudin Abdul Wahab Tengku Tengku Jamaluddin Hejar Abd Rahman Siti Masri Aziah Daud Malina Osman Rukman Awang Hamat Little is known on the knowledge, attitudes and preventive practices (KAP) of leptospirosis worldwide. This study embarked on assessing the KAP of leptospirosis among rural communities in Malaysia. A total of 444 participants (223 male; 221 female) aged between 18 and 81 years old were surveyed by using a self-administered questionnaire. A majority of participants had poor knowledge level (57.0%), unacceptable attitudes (90.3%) and unacceptable preventive practices (69.1%) on leptospirosis, and only 29.7% knew “rat-urine disease” as leptospirosis. Only 34.2% of the participants knew the bacteria could enter via wound lesions. Ethnicity and income were strongly associated with knowledge level and preventive practices, respectively (p-values < 0.05). As for attitudes, ethnicity, income and education type were significantly associated (p-values < 0.05). Only 36.5% of the participants were willing to see a doctor and did not mind if their house or surrounding area is dirty (59.7%). Surprisingly, only 32.9% had used rubber boots during floods. By logistic regression analysis, ethnicity was the only significant predictor for both knowledge level (an odds ratio (AOR) = 0.39, 95% confidence interval (CI) = 0.222–0.680) and preventive practices (AOR = 1.81, 95% CI = 1.204–2.734). Ethnicity (AOR = 0.40, 95% CI = 0.239–0.665), income (AOR = 1.58, 95% CI = 1.041–2.385) and education type (AOR = 3.69, 95% CI = 1.237–10.986) were strong predictors for attitudes. Among the KAP variables, attitude (AOR = 4.357, 95% CI = 2.613–7.264) was the only predictor for the preventive practices by logistic regression analysis. The KAP elements on leptospirosis are still lacking and poor health seeking behavior and attitudes are of our utmost concern. Thus, effective strategies should be planned to impart knowledge, and develop proactive approaches and good preventive modules on leptospirosis to this leptospirosis-prone community.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 2
    Keywords: Biological models ; Metabolism ; Proteomics ; Animal genetics ; Oncology ; Systems Biology ; Metabolomics ; Proteomics ; Animal Genetics and Genomics ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Recent Development in Omics Studies -- Functional Genomics -- Proteomics in Systems Biology -- Metabolomics in Systems Biology -- Integrative Multi-Omics Through Bioinformatics -- Index
    Abstract: This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics’ platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers’ understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run
    Pages: XIX, 99 p. 31 illus., 18 illus. in color. : online resource.
    ISBN: 9783319987583
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  • 3
    Keywords: Medicine ; Cytology ; Biomedical Engineering ; Biomedicine ; Biomedicine general ; Biomedical Engineering ; Biophysics and Biological Physics ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Fundamentals of Cavitation -- Cavitation Mapping -- Size Distribution of Cavitation Bubbles -- Cavitation Enhanced Thermal Effects and Applications -- Cavitation Enhanced Mechanical Effects and Applications -- Cavitation Control and Applications -- Cavitation Imaging in Tissues -- Laser Induced Cavitation and Photoacoustic Cavitation -- Cavitation Mechanobiology and Applications
    Abstract: This book offers a systematic introduction to the engineering principles and techniques of cavitation in biomedicine on the basis of its physics and mechanism. Adopting an interdisciplinary approach, it covers areas of interest ranging from physics and engineering to the biological and medical sciences. Individual chapters introduce the fundamentals of cavitation, describe its characterization, control and imaging techniques,℗ and present cavitation-enhanced thermal and mechanical effects and their applications. Intended as both a reference work for graduate students, and as a guide for scientists and engineers who work with cavitation in biomedicine, it provides a broad and solid foundation of knowledge. The aim is to bridge the different disciplines involved, and to promote cross-discipline research, thus encouraging innovations in the scientific research and engineering applications alike.℗ Dr. Mingxi Wan is a professor at Department of Biomedical Engineering, Xi€™án Jiao Tong University, Xi€™án, Shaanxi, China; Dr. Yi Feng works at Department of Biomedical Engineering, Xi€™án Jiao Tong University, Xi€™án, Shaanxi, China; Dr. Gail ter Haar is a professor at The Institute of Cancer Research, Sutton, Surry, UK.℗
    Pages: XVII, 503 p. 403 illus., 104 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9789401772556
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  • 4
    Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Cancer Cytogenetics: An Introduction -- Chromosome Preparation for Myeloid Malignancies -- Chromosome Preparation for Acute Lymphoblastic Leukemia -- Chromosome Preparation for Chronic Lymphoid Malignancies -- Cytogenetic Harvesting of Cancer Cells and Cell Lines -- Chromosome Bandings -- Chromosome Recognition -- Application of Fluorescence In Situ Hybridization Technology in Malignancies -- Fluorescence In Situ Hybridization Probe Preparation -- Fluorescence In Situ Hybridization Probe Validation for Clinical Use -- Fluorescence In Situ Hybridization on Tissue Sections -- Cytoplasmic Immunoglobulin Light Chain Revelation and Interphase Fluorescence In Situ Hybridization in Myeloma -- Quantitate Fluorescence In Situ Hybridization (QFISH) -- High Resolution of Fiber-Fluorescence In Situ Hybridization (Fiber-FISH) -- Array-Based Comparative Genomic Hybridization (aCGH) -- Multicolor Karyotyping and Fluorescence In Situ Hybridization-Banding (MCB/mBAND) -- Cytogenetics for Biological Dosimetry -- Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes -- Recurrent Cytogenetic Abnormalities in Acute Myeloid Leukemia -- Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia -- Recurrent Cytogenetic Abnormalities in Acute Lymphoid Leukemia -- Recurrent Cytogenetic Abnormalities in Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia -- Recurrent Cytogenetic Abnormalities in Multiple Myeloma -- Cytogenetic Nomenclature and Reporting -- Cytogenetic Resources and Information
    Abstract: This volume provides readers with detailed protocols covering the main cancer cytogenetics techniques needed for clinical utilization and research purposes. The chapters in this book cover topics such as chromosome preparation for myeloid malignancies; chromosome bandings; fluorescence in situ hybridization probe preparation; array-based comparative genomic hybridization; and cytogenetic nomenclature and reporting. The updated reviews on chromosomal abnormalities in hematological malignancies are excellent guides for cytogenetics data interpretations and specific malignant diseases correlation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cancer Cytogenetics: Methods and Protocols is a valuable resource for the novice in cytogenetics because it provides helpful guiding protocols, but it’s also great for those who are already engaged in the field and are looking for some technical hints
    Pages: XI, 340 p. 77 illus., 43 illus. in color. : online resource.
    ISBN: 9781493967032
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  • 5
    Unknown
    New York, NY : Springer
    Keywords: Neurosciences ; Proteomics ; Neurosciences ; Proteomics ; Springer eBooks
    Description / Table of Contents: Neuroproteomics: The Methods -- Dissection of Rodent Brain Regions: Guided Free-Hand Slicing and Dissection of Frozen Tissue -- Isolation of Synapse Sub-Domains by Subcellular Fractionation Using Sucrose Density Gradient Centrifugation: Purification of the Synaptosome, Synaptic Plasma Membrane, Postsynaptic Density, Synaptic Membrane Raft, and Postsynaptic Density Lattice -- Laser Microdissection for Spatial Proteomics of Post Mortem Brain Tissue -- High pH Reversed-Phase Pre-Fractionation for In-Depth Shotgun Proteomics -- Sample Preparation for Proteomics Analysis: Filter-Aided Sample Preparation (FASP) and Single-Pot Solid-Phase Sample Preparation (SP3) -- Enrichment of Low-Molecular-Weight Phosphorylated Biomolecules Using Phos-Tag Tip -- Integrated Immunoprecipitation: Blue Native Gel Electrophoresis - Mass Spectrometry for the Identification of Protein Sub-Complexes -- Analysis of Synaptic Protein-Protein Interaction by Crosslinking-Mass Spectrometry -- TMT-MS3 Enabled Proteomic Quantification of Human IPSC Derived Neurons -- Data Independent Acquisition (SWATH) Mass Spectrometry Analysis of Protein Content in Primary Neuronal Cultures -- Quantitative Analysis of Mass Spectrometry-Based Proteomics Data -- 2D-DIGE as a Tool in Neuroproteomics -- Neuropeptidomics of the Mammalian Brain -- MALDI Imaging Mass Spectrometry - Neurochemical Imaging of Proteins and Peptides -- A Combined Cellomics and Proteomics Approach to Uncover Neuronal Pathways to Psychiatric Disorder
    Abstract: This second edition volume expands on the previous edition with updates on the latest techniques used in the field of proteomics. Tissue and cellular proteins are now being analyzed at near proteome-wide levels and mass spectrometers are achieving higher sensitivity and speed, resolution, and accuracy. The chapters in this book cover various new methods used in proteomic workflows such as laser microdissection for spatial proteomics of post-mortem brain tissue, sample preparation in single vessel with FASP and SP3 protocols, the crosslinking mass spectrometry, TMT-MS3 based proteomic with synchronous precursor selection, mass spectrometric data dependent acquisition (DDA) and data independent acquisition (DIA, SWATH) methods, 2D-DIGE, and MALDI Imaging Mass Spectrometry. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neuroproteomics, Second Edition is a valuable guide that help researchers obtain the finest results from current proteomics platforms
    Pages: XIII, 218 p. 55 illus., 37 illus. in color. : online resource.
    Edition: 2nd ed. 2019.
    ISBN: 9781493996629
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  • 6
    Keywords: Life sciences ; Ophthalmology ; Cytology ; Life sciences ; Oxidative Stress ; Ophthalmology ; Apoptosis ; Springer eBooks
    Description / Table of Contents: 1 Oxidative Stress in Cornea -- 2 Corneal Degenerations -- 3 Corneal Epithelial Nuclear Ferritin and its Transporter Ferritoid Afford Unique Protection to DNA from U.V. Light and Reactive Oxygen Species -- 4 Excitatory Amino Acid Transporters, Xc- Antiporter, Glutamyl Transpeptidase, Glutamine Synthetase Activity and Glutathione in Human Corneal Epithelial Cells -- 5 Transforming Growth Factor – β3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts -- 6 Corneal Stem Cells: a Source of Cell Renewal with Therapeutic Potential -- 7 New Agents for Treating Dry Eye Syndrome -- 8 Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells -- 9 Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis -- 10 The Human Lens: A living Biometric Indicator of Health Status and Successful Aging -- 11 Oxidative Stress in Lens -- 12 Protein Serine/Threonine Phosphatases-1 and –2A in Lens Development and Pathogenesis -- 13 Proteases in Lens and Cataract -- 14 Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System -- 15 p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation -- 16 Etiology and Prevention of Cataract -- 17 The Effects of Lutein in Preventing Cataract Progression -- 18 Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts -- 19 Updates and Advances in Corneal Surgery -- 20 Cataract and Diabetic Retinopathy -- 21 Traumatic Cataract-a Review -- 22 Cataract in Paediatric Age Group-a Review
    Abstract: This comprehensive volume presents℗ data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss℗ topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised of four chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group. Studies on the Cornea and Lens is an essential addition to the library or department of physicians and scientists who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. This book is an authoritative contribution to Springeŕ€™s Oxidative Stress in Applied Basic Research and Clinical Practice series
    Pages: XVI, 447 p. 124 illus., 81 illus. in color. : online resource.
    ISBN: 9781493919352
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  • 7
    Keywords: Medicine ; Oncology ; Bioinformatics ; Biomedicine ; Cancer Research ; Oncology ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: 〈p〉Preface -- Survival Analysis -- Longitudinal Data Analysis -- Assessment of Diagnostic Tests and Instruments -- Analysis of Sequential Clinical Trials -- Dynamic Treatment Regimes -- Statistical Issues with Trial Data and Economic Modeling for Cost-effectiveness Evaluation -- Active-controlled Clinical Trials -- Thorough QT/QTc Clinical Trials -- Causal Inference in Cancer Clinical Trials -- Index.〈/p〉
    Abstract: 〈p〉This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing.℗ As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included.℗ The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens.℗ 〈/p〉〈p〉The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.℗ ℗ ℗ 〈/p〉
    Pages: : digital.
    ISBN: 9781461443223
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  • 8
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract. A thermophilic Bacillus stearothermophilus F1 that produced an extremely thermostable alkaline protease was isolated from decomposed oil palm branches. The isolated protease was purified to homogeneity by heat treatment, ultrafiltration and gel filtration chromatography with a 128-fold increase in specific activity and 75% recovery. The protease, which is a serine-type enzyme, has a relative molecular mass of 33 500 by sodium dodecyl sulphate-polyacrylamide gel electrophoresis but only 20 000 by gel-filtration chromatography. The enzyme was optimally active at pH 9.0 and was stable for 24 h at 70° C and in the pH range from 8.0 to 10.0. It was capable of hydrolysing many soluble and insoluble protein substrates but no esterase activity was detected. The enzyme activity was markedly inhibited by Co2+ and Hg2+, whereas Mg2+, Fe2+, Cu2+, Zn2+ and Sr2+ had little or no inhibitory effect. However, Mn2+ strongly activated the protease activity. The protease exhibited a high degree of thermostability [t 1/2 (85° C)=4 h, (90° C)=25 min]. The stability at higher temperatures (85° C and above) was shown to be dependent on the presence of Ca2+.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1423-0127
    Keywords: SK&F 96365 ; Crotamine ; Calcium channel blocker ; Local anesthetic ; Sodium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of SK&F 96365, a blocker of the receptor-operated Ca2+ channel, on contractilities and the Na+ channel of mouse diaphragm were studied. SK&F 96365 (10–50 µM) reversibly inhibited twitches, tetanic contractions and muscle and nerve action potentials. The IC50 was 17–24 µM. The inward Na+ current was suppressed and its recovery from inactivations delayed. Crotamine, a peptide toxin that binds to neurotoxin receptor site 3 of the muscle Na+ channel, enhanced the inhibitory effects of SK&F 96365 and reduced the IC50 to about 4 µM. Veratridine had similar effects, although it was less effective than crotamine. On the other hand, the crotamine-induced membrane depolarizations and spontaneous discharges of muscle action potentials were inhibited by SK&F 96365 noncompetitively. The inhibitory effects of tetrodotoxin and tetracaine were additive with those of SK&F 96365 but were enhanced slightly by crotamine. The results suggested that SK&F 96365 acts on a distinct site and blocks the Na+ channel of excitable membranes at a concentration range that inhibits the receptor-operated calcium channel.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A thermophilic Bacillus stearothermophilus F1 that produced an extremely thermostable alkaline protease was isolated from decomposed oil palm branches. The isolated protease was purified to homogeneity by heat treatment, ultrafiltration and gel filtration chromatography with a 128-fold increase in specific activity and 75% recovery. The protease, which is a serine-type enzyme, has a relative molecular mass of 33 500 by sodium dodecyl sulphate-polyacrylamide gel electrophoresis but only 20 000 by gel-filtration chromatography. The enzyme was optimally active at pH 9.0 and was stable for 24 h at 70° C and in the pH range from 8.0 to 10.0. It was capable of hydrolysing many soluble and insoluble protein substrates but no esterase activity was detected. The enzyme activity was markedly inhibited by Co2+ and Hg2+, whereas Mg2+, Fe2+, Cu2+, Zn2+ and Sr2+ had little or no inhibitory effect. However, Mn2+ strongly activated the protease activity. The protease exhibited a high degree of thermostability [t 1/2 (85° C) = 4 h, (90° C) = 25 min]. The stability at higher temperatures (85° C and above) was shown to be dependent on the presence of Ca2+.
    Type of Medium: Electronic Resource
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