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  • 1
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Diabetes mellitus ; Cystinosis ; Indomethacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 13-month-old infant was admitted to our Institution because of difficult metabolic control of diabetes mellitus. Clinical and laboratory findings revealed that the child was affected by both insulin-dependent diabetes mellitus and nephropathic cystinosis. Treatment with indomethacin was associated with growth improvement at an early stage of renal insufficiency, but not in more advanced renal failure.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: 18-OH-Corticosteron ; Aldosteron ; Radioimmunoassay ; Hypertonie ; Primärer Hyperaldosteronismus ; 18-OH-corticosterone ; Aldosterone ; Radioimmunoassay ; Hypertension ; Primary hyperaldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aldosterone-18-glucuronide, free aldosterone, free 18-OH-deoxycorticosterone, and tetrahydroaldosterone radioimmunoassays were performed in urine samples from normal subjects, as well as from patients with essential hypertension and primary hyperaldosteronism. The aldosterone-18-glucuronide measurements were made on 1119 urine samples, with and without chromatographic separation, with antisera raised against 3 different types of aldosterone antigens. Good correlations were found between the values obtained with the different methods. However, the values measured without chromatography were usually higher and individual discrepancies between results obtained with and without chromatography were observed. The antiserum raised against an aldosterone-3-oxime antigen produced the most reliable results without prior chromatography, but the values were still higher than after chromatography in 4.33% of 854 cases. These values may be clinically misleading, and we therefore recommend the aldosterone-18-glucuronide estimation without chromatography as a screening method only. When the results of the aldosterone-18-glucuronide, free aldosterone, free 18-OH-deoxycorticosterone, and tetrahydroaldosterone assays were compared, free aldosterone was found to correlate the best with the results of all other assays. There were also correlations among the other assays. The aldosterone-18-glucuronide estimation is currently the most frequently used assay. This study revealed, however, that in patients with essential hypertension and primary aldosteronism, normal aldosterone-18-glucuronide levels can be accompanied by high free aldosterone and tetrahydroaldosterone levels. We conclude, therefore, that the aldosterone-18-glucuronide assay may not be sufficient to select all patients with hyperaldosteronism. Additionally, a radioimmunoassay of urinary free 18-OH-corticosterone was developed and used as an aid in the aldosterone diagnosis. The excretion levels were 1.5–6.5, with a mean value (± SD) of 4.0±1.44 µg/24 h. These values also correlated with the different aldosterone measurements, and correlated best with the free aldosterone values.
    Notes: Zusammenfassung Aldosteron-18-Glucuronid Bestimmungen wurden von Urinproben (n=1119) vor und nach Chromotagraphie mit Hilfe von Antikörpern durchgeführt, die gegen drei verschiedene Typen von Aldosteron Antigenen erzeugt wurden. Die Werte vor und nach Chromatographie zeigten eine hochsignifikante Korrelation. Dennoch lagen die Bestimmungen, die ohne einen Isolierungsschritt vorgenommen wurden, im allgemeinen höher und in Einzelfällen gab es Dissoziationen der Werte. Mit einem Aldosteron-3-oxim-Antiserum wurden die zuverlässigsten Bestimmungen ohne Chromatographie erzielt. Auch mit diesem Antiserum wurden jedoch überhöhte Werte in 4,33% der Tests (n=854) bestimmt, die als klinisch irreführend bezeichnet werden können. Die Technik ohne Chromatographie ist deswegen nur für Screening-Zwecke akzeptabel. Aldosteron-18-Glucuronid, freies Aldosteron, freies 18-Hydroxycorticosteron, freies 18-Hydroxydeoxycorticosteron und Tetrahydroaldosteron wurden radioimmunologisch aus Urinproben von Normalpatienten, von Patienten mit essentieller Hypertonie und mit primärem Hyperaldosteronismus bestimmt. Die Resultate wurden untereinander verglichen. Die verschiedenen Größen korrelierten signifikant miteinander, doch die Korrelationskoeffizienten waren sehr unterschiedlich. Die besten Korrelationen wurden errechnet, wenn freie Urinaldosteron Werte mit den anderen Größen verglichen wurden. Die Bestimmung von Aldosteron-18-Glucuronid ist zur Zeit die am meisten durchgeführte Bestimmung. Bei einer Gruppe von Patienten mit essentieller Hypertonie und auch bei Patienten mit primärem Hyperaldosteronismus waren die Aldosteron-18-Glucuronid Werte innerhalb des Normbereiches, während die Exkretion des freien Urin-Aldosterons und des Tetrahydroaldosterons erhöht war. Wir schließen daraus, daß die Bestimmung des Aldosteron-18-Glucuronids für die Diagnose einer Aldosteron Hyperproduktion nicht immer ausreicht. Es wurde zusätzlich ein Assay für freies 18-Hydroxycorticosteron im Urin entwickelt, um die Aldosteron Diagnostik zu stützen. Der Normalbereich war 1,5–6,5 µg/24 h. Der Durchschnitt (± SD) lag bei 4,0±1,44 µg/24 h. Diese Werte korrelieren besonders gut mit den Bestimmungen von freiem Aldosteron.
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  • 4
    ISSN: 1437-9813
    Keywords: Augmentation enterocystoplasty ; Hyperchloremic acidosis ; Hypercalciuria ; Hyperphosphaturia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent reports have shown that metabolic acidosis is a possible complication in patients who undergo augmentation enterocystoplasty. We studied 30 patients with neurogenic bladder who underwent sigmoidocystoplasty. Follow-up ranged from 1 to 10 years; all the patients showed normal renal function. We found significant hyperchloremic acidosis in 10% and borderline acidosis in 27% of the patients. Abnormalities of calcium and phosphorus balance were noted in 16.5% and 43% of the patients respectively, and more frequently in acidolic patients, which might be the result of activation of the bony buffers and might cause delayed growth in children. Close follow-up of all patients with enterocystoplasty is required, and oral bicarbonate is indicated when acidosis is detected.
    Type of Medium: Electronic Resource
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