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  • 1
    Unknown
    Malden, MA : Blackwell Pub.
    Call number: QH431:51(7)
    Keywords: Genetic Engineering ; DNA, Recombinant ; Chromosome Mapping ; Base Sequence ; Genomics
    Notes: Rev. ed. of: Principles of gene manipulation. 6th ed. 2001 and: Principles of genome analysis and genomics / Sandy B. Primrose, Richard M. Twyman. 3rd ed. 2003.
    Pages: xxii, 644 p. : ill.
    Edition: 7th ed.
    ISBN: 9781405135443
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    QH431:51(7) available
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  • 2
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    LONDON U. A.: BAILLIERE TINDALL
    Call number: QZ200Z:236/2,2
    Pages: IX S., S. 261-503.
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    QZ200Z:236/2,2 available
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  • 3
    Call number: 08-Ult
    Keywords: Ultrasonics in obstetrics / Safety measures ; Generative organs, Female / Ultrasonic imaging ; Diagnosis, Ultrasonic / Safety measures
    Pages: ix, 147 p. : ill.
    ISBN: 1850706468
    Signatur Availability
    08-Ult departmental collection or stack – please contact the library
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  • 4
    Unknown
    Malden, MA : Blackwell Pub.
    Call number: QH442:180
    Keywords: Genomics ; Molecular Biology ; Biotechnology
    Description / Table of Contents: Biotechnology and genomics in medicine -- An overview of genomics -- Genomics and the challenge of infectious disease -- Analysing and treating genetic diseases -- Diagnosis and treatment of cancer -- The large scale production of Biopharmaceuticals -- Genomics and the development of new chemical entities -- Gene and cell therapies
    Notes: Includes index.
    Pages: xiv, 216 p.
    ISBN: 1405108193
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    QH442:180 available
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  • 5
    Unknown
    Hoboken, NJ : Wiley Pub.
    Call number: QH587:22
    Keywords: Stem Cells
    Notes: Includes index.
    Pages: xvi, 360 p. : ill.
    ISBN: 9780470259283
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    QH587:22 available
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  • 6
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Introduction: Defining the position of Non-Biological Complex Drugs -- Polymeric micelles -- Liposomes: the science and the regulatory landscape -- Glatiramoids -- Iron carbohydrate complexes: characteristics and regulatory challenges -- Drug Nanocrystals -- Analytical methods for determining the size (distribution) in parenternal dispersions -- NBCD Pharmacokinetics and Bioanalytical Methods to Measure Drug Release -- Low Molecular Weight Heparins, Biological Drugs close to Non-Biological Complex Drugs -- Nanoparticle Albumin-Bound Anticancer Agents -- The EU regulatory landscape of Non-Biological Complex Drugs -- What did we learn? What can we expect in the future? Concluding remarks and outstanding issues
    Abstract: The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs.℗ Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.℗
    Pages: IX, 390 p. 91 illus., 57 illus. in color. : online resource.
    ISBN: 9783319162416
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  • 7
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Restriction endonuclease maps were constructed for the genome of a porcine adenovirus (PAV), NADC-1, which was isolated in 1972 from an adult swine. Genomic DNA libraries of NADC-1 Bam HI, Eco RI/Bam HI, and Sph I fragments were cloned into pUC-18. Using the cloned NADC-1 Bam HI and Eco RI/Bam HI fragments as probes, Southern blot hybridizations were performed to human adenovirus 2 (Ad-2) restriction fragments to determine the left-to-right orientation of the Bam HI and Eco RI/Bam HI fragments. Genomic NADC-1 DNA was cleaved with ten restriction endonucleases (RE). Using cloned NADC-1 genomic fragments as probes in Southern blot hybridizations, an RE site map was constructed. Nucleotide sequencing of four clones confirmed several RE sites. The size of the NADC-1 genome was determined to be approximately 32 kbp. The size of Hind III, Xba I, Sma I, Eco RI, Bam HI, Bgl II, Pst I, and Sph I RE fragments from NADC-1 was compared to those from the reference strain of PAV serotype 4 (F 618), and to two recent isolates, NADC-2 and NADC-3. For all restriction enzymes examined, the sizes of the NADC-1 fragments were identical to PAV-4, NADC-2, and NADC-3 fragments, indicating that the NADC-1 isolate is very closely related, if not identical, to PAV-4 and two recent isolates. Southern blot hybridizations also indicated that NADC-1, NADC-2, NADC-3, and PAV-4 are very similar and revealed regions of sequence similarity between NADC-1 and human Ad-2 and human Ad-5.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0789
    Keywords: Key words Oxalate ; Mycorrhizae ; Arid lands ; P cycling ; Hysterangium separabile ; Glomus spp. ; Acaulospora elegans ; Benomyl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Oxalate crystals and elements binding to the surfaces of mycorrhizal fungal hyphae were examined using scanning electron microscopy coupled with X-ray analysis of elemental composition. Mycorrhizae from the arid zone vegetation types in southern California were examined including chaparral, riparian oak woodlands, coastal sage, grasslands, and deserts. Only mat-forming ectomycorrhizal hyphae, such as Hysterangium separabile, were found to produce oxalate crystals. None of the arbuscular mycorrhizal fungal hyphae (Glomus spp. and Acaulospora elegans) examined had crystal structures associated with them. The hyphae of Hysterangium separabile without crystals did not show the Ca peaks that were present when the crystals existed nor did the arbuscular mycorrhizal fungal hyphae have the Ca peaks. The elimination of arbuscular mycorrhizae using benomyl did not affect soil P or oxalate. These data indicate that there are some fundamental differences in chemical exudation between mycorrhizal fungi that could affect P uptake and cycling in arid ecosystems.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0789
    Keywords: Oxalate ; Mycorrhizae ; Arid lands ; P cycling ; Hysterangium separabile ; Glomus spp. ; Acaulospora elegans ; Benomyl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Oxalate crystals and elements binding to the surfaces of mycorrhizal fungal hyphae were examined using scanning electron microscopy coupled with X-ray analysis of elemental composition. Mycorrhizae from the arid zone vegetation types in southern California were examined including chaparral, riparian oak woodlands, coastal sage, grasslands, and deserts. Only mat-forming ectomycorrhizal hyphae, such as Hysterangium separabile, were found to produce oxalate crystals. None of the arbuscular mycorrhizal fungal hyphae (Glomus spp. and Acaulospora elegans) examined had crystal structures associated with them. The hyphae of Hysterangium separabile without crystals did not show the Ca peaks that were present when the crystals existed nor did the arbuscular mycorrhizal fungal hyphae have the Ca peaks. The elimination of arbuscular mycorrhizae using benomyl did not affect soil P or oxalate. These data indicate that there are some fundamental differences in chemical exudation between mycorrhizal fungi that could affect P uptake and cycling in arid ecosystems.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-601X
    Keywords: 25.85.Ge ; 25.85.Ee
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Mass resolved fission fragment angular distribution was measured in the 28.5 MeV alpha induced fission of233U using recoil catcher technique and direct gamma spectrometry. The angular distribution of 8 fission products were obtained. The angular anisotropies of asymmetric fission products were found to be higher than those of symmetric products indicating a correlation between the fragment angular distribution and the mass distribution.
    Type of Medium: Electronic Resource
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