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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Süddeutscher Kongress für Kinder- und Jugendmedizin; 65. Jahrestagung der Süddeutschen Gesellschaft für Kinder- und Jugendmedizin gemeinsam mit der Süddeutschen Gesellschaft für Kinderchirurgie und dem Berufsverband der Kinder- und Jugendärzte e.V. - Landesverband Hessen; 20160520-20160521; Bad Nauheim; DOC16sgkjP16 /20160506/
    Publication Date: 2016-05-12
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds241 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 1432-1076
    Keywords: Key words Nitrogen dioxide  ;  Nitric oxide  ;   Inhaled nitric oxide  ;  Pulmonary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to analyse the time response to nitric oxide (NO) dosing changes as well as the formation of nitrogen dioxide (NO2) with different ventilation systems, respirator settings and application sites during NO inhalation. The inspired NO and NO2 concentrations were continuously measured using chemiluminiscence within a dummy ventilatory system equipped with two different respirator systems (Siemens Servo 900c and Bear BP 2001). NO was either introduced into the afferent limb of the ventilatory circuit close to the endotracheal tube (site A) or into the so-called low pressure port of the Servo 900c respirator, far away from the endotracheal tube (site B). In addition, the decay of the inspired NO concentration after cessation of the NO gas flow was studied. This decay was considerably prolonged when NO was introduced at site B (time constants: τ = 7.19 min versus τ = 0.29 min). Within the concentration range studied (0–25 ppm NO) a linear correlation between the NO and NO2 concentration was found. At site A and an inspired oxygen concentration of 〉 0.95 NO2 formation amounts to 1.14% ± 0.11% of the NO concentration. Using this value one can calculate the NO2 formation for a given NO dose. For example, when 40 ppm NO are applied, a concentration of 0.45 ppm NO2 can be expected, which is well below the relevant toxic concentrations. However, when NO was introduced at site B, NO2 formation was significantly increased to 1.61% ± 0.16%. Passage of the ventilated gas through soda lime led only to a slight and insignificant reduction in NO2 concentration. The continuous flow respirator BP 2001 showed a significantly lower NO2 concentration when compared to the non-continuous flow respirator Servo 900c (0.64 ± 0.11% vs.1.14 ± 0.11%). Conclusion The application of NO close to the endotracheal tube is associated with a much faster response of the actual inspired NO concentration to dosing changes and shows the lowest NO2 formation. In order to avoid toxic NO2 concentrations, an upper limit of 40 ppm NO is recommended for continuous NO inhalation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Linksventrikuläre Tachykardie ; Elektrophysiologische Diagnostik und Therapie ; Key words Leftventricular tachycardia ; Electrophysiological diagnosis and therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report about the possibility of electrophysiological diagnosis and therapy in the treatment of a symptomatic left ventricular tachycardia which could not be treated effectively by oral medical therapy in a 10 year old boy with no obvious structural heart disease. By right bundle-bloc-like QRS-complexes in the surface-ECG, the diagnosis of the ventricular origin of the tachycardia was confirmed by transesophageal-ECG. This was followed by the first electrophysiological examination that showed increased leftventricular vulnerability. During this electrophysiological examination the tachycardia was terminated by stimulated singular premature beats. An oral medical therapy with sotalol was started. After the phase of saturation the next ventricular stimulation was done, that showed no sufficient protection of sotalol against VT. So the decision was made for ventricular ablation. After 5 high frequency-applications no furhter ventricular tachycardia could be induced. Since this intervention the patient lives without symptoms
    Notes: Zusammenfassung Wir berichten über die Möglichkeiten der elektrophysiologischen Diagnostik und Therapie in der Behandlung einer medikamentös nicht sicher einstellbaren symptomatischen linksventrikulären Tachykardie bei einem 10jährigen Jungen mit strukturell unauffälligem kardialem Befund. Bei rechtsschenkelblockartig deformierten QRS-Komplexen im Oberflächen-EGK bei der Aufnahme wurde anhand eines anschließend abgeleiteten Ösophagus-EKG die ventrikuläre Genese der Tachykardie bestätigt. Es erfolgte dann eine erste elektrophysiologische Untersuchung, die eine erhöhte linksventrikuläre Vulnerabilität zeigte. Im Rahmen dieser Untersuchung wurde mittels gezielter ventrikulärer Einzelstimulation die Tachykardie terminiert. Anschließend erfolgte eine medikamentöse Einstellung auf Sotalol. Nach der Aufsättigungsphase wurde eine erneute ventrikuläre Stimulation durchgeführt, die keine Schutzwirkung der Sotalolmedikation nachweisen konnte, so daß die Indikation für eine ventrikuläre Katheterablation gestellt wurde. Nach 5 Hochfrequenzapplikationen linksseptal ließ sich keine ventrikuläre Tachykardie mehr induzieren. Der Patient ist im bisherigen Nachbeobachtungszeitraum beschwerdefrei.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1971
    Keywords: Key words: Congenital heart disease — 5-Hydroxyindoleacetic acid — Pulmonary hypertension — Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Serotonin (5HT) is a potent vasoconstrictor of the pulmonary vascular bed and may be involved in the pathophysiology of secondary pulmonary hypertension in children with a left-to-right shunt due to a congenital heart defect. To test this hypothesis we measured the total and free 5HT concentration in blood as well as the urinary excretion of its main metabolite 5-hydroxyindoleacetic acid (HIAA) in children showing a left-to-right shunt with (n= 10) and without (n= 18) pulmonary hypertension. 5HT and HIAA were also measured in children after corrective cardiac surgery using cardiopulmonary bypass (n= 14) and in controls without congenital heart disease (n= 18). The concentrations of total and free 5HT were not significantly different between controls and patients with a left-to-right shunt. After cardiac surgery total 5HT concentration was significantly reduced by about 65% owing to a postoperatively reduced platelet count. In patients with a left-to-right shunt the total 5HT content was similar in the right atrium (204.0 ± 17.3 ng/ml), pulmonary artery (189.0 ± 19.1 ng/ml), and aorta (195.0 ± 19.3 ng/ml), as was the free 5HT concentration. Therefore no net release of 5HT from platelets occurred between these sampling sites. In patients with pulmonary hypertension, the urinary excretion of HIAA was significantly increased when compared with controls and patients without pulmonary hypertension. It is concluded that turbulent blood flow in children with a left-to-right shunt does not lead to a significant release of 5HT from platelets. However, the increased urinary excretion of HIAA in patients with pulmonary hypertension indicates an increased turnover of 5HT, probably due to an increased number of intrapulmonary neuroepithelial cells or a higher metabolic rate of 5HT within those cells.
    Type of Medium: Electronic Resource
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