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  • 1
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    Totowa, N.J. : Humana Press
    Associated volumes
    Call number: QH506:60/350
    Keywords: Protein Folding ; Protein Conformation ; Proteins / analysis
    Pages: xiii, 327 p. : ill.
    ISBN: 9781588296221
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  • 2
    Keywords: Neurosciences ; Human Physiology ; Medicine ; Neurosciences ; Human Physiology ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Molecular Mechanisms of the sense of touch: an overview of mechanical transduction and transmission in Merkel discs of whisker hair follicles and some clinical perspectives -- TRP Channels in Nociception and Pathological Pain -- Involvement of TRPV1-ANO1 interactions in pain enhancing mechanisms -- Roles of ASICs in Nociception and Proprioception -- Tackling pain associated with rheumatoid arthritis: Proton-sensing receptors -- Intra-Fascicular Local Anesthetic Injection damages Peripheral Nerve Induced Neuropathic Pain -- Microglia in the CNS and neuropathic pain -- Descending noradrenergic inhibition €“án important mechanism of gabapentin analgesia in neuropathic pain -- Chronic neuropathic pain protects heart from ischemia reperfusion injury -- Knowing the neuronal mechanism of spontaneous pain to treat chronic pain in future -- Role of Neuroinflammation in Opioid Tolerance: Translational Evidence from Human-to-Rodent Studies -- Neural mechanisms of offset analgesia -- Cortical LTP: A synaptic model for chronic pain -- Pain-associated neural plasticity in the parabrachial to central amygdala circuit -- Electrophysiological signature of pain -- Neuroimaging Studies of Primary Dysmenorrhea -- Brain reward circuit and pain -- The Involvement of P2X7 Receptors and BDNF in the Pathogenesis of Central Post Stroke Pain -- Melatonin: A new-generation therapy for reducing chronic pain and improving sleep disorder-related pain -- Central poststroke pain, comorbidity, and associated symptoms in animal and human models
    Abstract: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 19 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience
    Pages: X, 265 p. 44 illus., 28 illus. in color. : online resource.
    ISBN: 9789811317569
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  • 3
    Keywords: Medicine ; Radiology ; Medicine & Public Health ; Imaging / Radiology ; Springer eBooks
    Description / Table of Contents: Before In Vivo Imaging: Evaluation of Fluorescent Probes using Fluorescence Microscopy, Multiplate Reader, and Cytotoxicity Assays -- Bioconjugation Methods for Coupling Targeting Ligands with Fluorescent Dyes -- In Vivo Fluorescence Reflectance Imaging with Subcutaneous Mouse Tumor Models -- FRET Imaging of Enzymatic Activities Using Smart Probes -- Fluorescence Imaging of Inflammation in Live Animals -- Fluorescence Lifetime Imaging of Cancer In Vivo -- Non-Invasive Imaging of Fluorescent Reporters in Small Rodent Models Using Fluorescence Molecular Tomography -- In Vivo Tumor Angiogenesis Imaging Using Peptide-Based Near-Infrared Fluorescent Probes -- Intraoperative Fluorescence Imaging and Multimodal Surgical Navigation Using Goggle System -- Utilization of Near-Infrared Fluorescent Imaging for Pharmaceutically Relevant Applications -- In Vivo Cell Tracking Using Two-Photon Microscopy -- Small Animal Imaging Using Diffuse Fluorescence Tomography -- In Vivo Metal Ion Imaging Using Fluorescent Sensors -- Using Fluorescence Imaging to Track Drug Delivery and Guide Treatment Planning In Vivo -- In Vivo Fluorescence Imaging in the Second Near-Infrared Window Using Carbon Nanotubes -- Ex Vivo Imaging, Biodistribution, and Histological Study in Addition to In Vivo Imaging -- Experimental Design and Data Analysis of In Vivo Fluorescence Imaging Studies
    Abstract: This detailed volume includes a rich variety of applications using various instrumentations, probes, disease models, and targets in order to account for the multidisciplinary nature of the use of in vivo fluorescence imagine. The book also includes chapters on the emerging fields of cell tracking, image-guided treatment, and fluorescence imaging in the second NIR window, as well as protocols for evaluation methods before and after in vivo imaging. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Vivo Fluorescence Imaging: Methods and Protocols serves as a valuable reference for researchers from numerous fields who wish to become more familiar with in vivo fluorescence imaging techniques
    Pages: X, 213 p. 67 illus., 59 illus. in color. : online resource.
    ISBN: 9781493937219
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  • 4
    ISSN: 1572-8986
    Keywords: ammonia synthesis ; strong electric field discharge ; nonequilibrium plasma ; ambient pressure ; MgO catalyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract The plasma synthesis of ammonia has been studied in a nitrogen–hydrogenplasma using a strong electric field discharge at ambient pressure andtemperature. With this method, N2 and H2 molecules are ionized anddissociated and a large number of free atoms, ions, and radicals areformed in a nonequilibrium plasma after inelastic collisions. The finalproduct was mainly ammonia, including a small amount of hydrazine. WhenMgO powder, used as a catalyst, was smeared on the surface of the electrodeplates, the yields of ammonia increased about 1.54–1.75 times andreached 5000 ppm (0.5% v/v). In this way, plasma synthesis of ammonia atambient pressure is realized and a new method is provided for inorganicsynthesis, which consumes little energy and simplifies the process.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-6776
    Keywords: gene cloning ; Paenibacillus sp. ; sequence homology ; xylanase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Two genes, xynA and xynB, encoding xylanases from Paenibacillus sp. KCTC 8848P were cloned and expressed in Escherichia coli, and their nucleotide sequences were determined. The xylanases of E. coli transformants were released into the extracellular culture fluid in the absence of xylan. The structural gene of xynA 636 bp, encoded a protein of 212 amino acids, while the xynB gene consisted of 951 bp open reading frame for a protein of 317 amino acids. The amino acid sequence of the xynAgene showed 83% similarity to the xylanase of Aeromonas caviae, and belonged to the family 11 glycosyl hydrolases. The deduced amino acid sequence of the xynB gene, however, showed 51% similarity to the xylanase of Rhodothermus marinus, and belonged to the family 10 glycosyl hydrolases.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-6776
    Keywords: β-amylase ; gene cloning and expression ; Saprolegnia ferax ; sequence homology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Genomic DNA and cDNA encoding the β-amylase from the oomycete, Saprolegnia ferax, were cloned into Saccharomyces cerevisiae and analyzed. The Spl. ferax β-amylase gene consisted of a 1350 bp open reading frame, encoding a protein of 450 amino acids with a calculated mass of 49 353 Da, and was not interrupted by any intron. The deduced amino acid sequence of the β-amylase gene had 42% similarity to the β-amylase of Arabidopsis thaliana. The β-amylase gene was expressed in Sacc. cerevisiae and its product was secreted into the culture medium.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-269X
    Keywords: material failure ; evolution-induced catastrophe ; sample-specificity ; binary failure probability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In order to study the failure of disordered materials, theensemble evolution of a nonlinear chain model was examined by using astochastic slice sampling method. The following results were obtained.(1) Sample-specific behavior, i.e. evolutions are different from sampleto sample in some cases under the same macroscopic conditions, isobserved for various load-sharing rules except in the globally meanfield theory. The evolution according to the cluster load-sharing rule,which reflects the interaction between broken clusters, cannot bepredicted by a simple criterion from the initial damage pattern and eventhen is most complicated. (2) A binary failure probability, itstransitional region, where globally stable (GS) modes andevolution-induced catastrophic (EIC) modes coexist, and thecorresponding scaling laws are fundamental to the failure. There is asensitive zone in the vicinity of the boundary between the GS and EICregions in phase space, where a slight stochastic increment in damagecan trigger a radical transition from GS to EIC. (3) The distribution ofstrength is obtained from the binary failure probability. This, likesample-specificity, originates from a trans-scale sensitivity linkingmeso-scopic and macroscopic phenomena. (4) Strong fluctuations in stressdistribution different from that of GS modes may be assumed as aprecursor of evolution-induced catastrophe (EIC).
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 93 (1992), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The application of Phaffia rhodozyma as an astaxanthin source in the aquaculture industry is limited because of the low carotenoid content of natural isolates. We constructed carotenoid hyperproducing hybrids of P. rhodozyma by protoplast fusion from parental strains that produced approx. 1600 μg carotenoid/g yeast and were auxotrophic for tryptophan, leucine, methionine or arginine. The hybrids were stable and consistently produced 〉 2000 μg carotenoid/g yeast. Karyogamy was confirmed by the isolation of recombinants after mitotic segregation of parental auxotrophic genetic markers, the increased content of DNA/cell and the presence of a single nucleus per cell. The results of this study indicated that protoplast fusion is promising for strain improvement in P. rhodozyma.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A pyocyanin overproducer with insertional inactivation of ptsP gene was isolated from a mini-Mu insertion library in Pseudomonas aeruginosa PA68. The mutation was complemented by a functional ptsP gene in trans. The pyocyanin-overproducing phenotype was also found in a ptsP mutant constructed by gene replacement in the P. aeruginosa PAO1 strain. Reporter plasmids with PqscR-lacZ, PlasI-lacZ and PrhlI-lacZ were constructed and the β-galactosidase activity in the ptsP mutant/wild-type background was measured. The results showed that lack of Enzyme INtr (EINtr, encoded by ptsP) decreased transcription from the PqscR promoter and increased the activity of the PlasI and PrhlI promoters. Normally, QscR represses the quorum-sensing LasR-LasI and RhlR-RhlI systems involved in pyocyanin regulation. Our results showed that the ptsP gene has an important role in the regulation of pyocyanin production and that two quorum-sensing systems and their repressor QscR are involved in this regulation.
    Type of Medium: Electronic Resource
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