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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 70. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 92. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 47. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20061002-20061006; Berlin; DOCE.4.1-1716 /20060928/
    Publication Date: 2007-03-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  122. Kongress der Deutschen Gesellschaft für Chirurgie; 20050405-20050408; München; DOC05dgch3014 /20050615/
    Publication Date: 2005-06-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  Kooperative Versorgung - Vernetzte Forschung - Ubiquitäre Information; 49. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 19. Jahrestagung der Schweizerischen Gesellschaft für Medizinische Informatik (SGMI) und Jahrestagung 2004 des Arbeitskreises Medizinische Informatik (ÖAKMI) der Österreichischen Computer Gesellschaft (OCG) und der Österreichischen Gesellschaft für Biomedizinische Technik (ÖGBMT); 20040926-20040930; Innsbruck; DOC04gmds127 /20040914/
    Publication Date: 2004-09-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 7; DOC43 /20071219/
    Publication Date: 2007-12-19
    Description: Parallel with the initiation of an integrated curriculum at the Medical University of Graz a virtual learning environment was implemented, designated as Virtual Medical Campus (VMC). Several financial support projects made the development of the VMC and its enhancements possible. Learning objects are granular and strictly equipped with a set of metadata conforming the SCORM 2004 2nd edition-standard and are therefore reusable and exchangeable with other study courses or e-Learning-systems. Simple usability allows authors the intuitive creation of content, which may be enriched with interactive and tutorial systems using several built in authoring tools like web-based-training or a Virtual Microscope. In 2005 more than 3300 students applied for human medicine at the Medical University of Graz and it was decided to give a virtual term with a selection process at the end of it. More than 1 million accesses to learning objects and 257,000 web-based-trainings were handled without a single breakdown. This unique interim solution of a virtual term demonstrated the capacity of the VMC-system and the organisational possibility to intercept rushes of application using e-Learning. In the meanwhile the VMC Graz provides 13 study courses at four universities in two different European countries and two international postgraduate programs. The technical development aims at Web 〈TextGroup〉 3.0 - 〈/TextGroup〉 "Semantic Web" and the further expansion of co-operations is a present and future strategy.
    Description: Vor dem Hintergrund der Einführung neuer Studienpläne an der Medizinischen Universität Graz entstand ein Lerninformationssystem, der Virtuelle Medizinische Campus (VMC) Graz. Mehrere Förderungen machten den Auf- und Ausbau des Systems möglich. Die SCORM-konforme Ausstattung der Lernobjekte mit Metadaten erlaubt Wiederverwendung und Austausch der Lernobjekte mit anderen Studiengängen und Systemen. Eine möglichst einfache und intuitive Bedienung gewährleistet, dass Autorinnen und Autoren Inhalte unkompliziert in das Repository des Systems uploaden können. Einige spezielle Autorentools erleichtern dabei die Bereicherung mit interaktiven tutoriellen Inhalten. Im Jahr 2005 sah sich die Medizinische Universität Graz, bedingt durch ein EuGh-Urteil mit mehr als 3300 StudieninteressentInnen für Human- und Zahnmedizin konfrontiert und entschloss sich, als einmalige Puffermaßnahme das erste Semester ausschließlich virtuell abzuhalten mit Prüfungen in Präsenzform am Ende des Semesters. Mehr als 1 Million Lernobjektaufrufe aus allen Studiengängen und 257.000 Web-based-Training-Absolvierungen wurden dabei ohne einen einzigen Ausfall bewältigt. Diese einmalige Zwischenlösung eines virtuellen Eingangssemesters zeigte die potentielle Leistungsfähigkeit des Systems und die organisatorischen Möglichkeiten, kurzfristige Belastungsspitzen durch e-Learning abzufangen. Mittlerweile versorgt der VMC Graz mit 13 Studiengängen vier Universitäten in zwei europäischen Staaten sowie zwei internationale postgradule Programme mit seinem e-Learning-System. Für die Zukunft geht die technische Entwicklung des VMC in Richtung Web 3.0 - "Semantic Web", die inhaltliche und strategische Entwicklung schlägt einen vergleichbaren Weg ein und ist von einem weiteren Ausbau von Kooperationen geprägt.
    Keywords: VMC ; Virtual Medical Campus ; e-learning ; eLearning ; learning management system ; virtual learning environment ; university ; Medical University of Graz ; new media ; new media in education ; blended learning ; repository ; Web 2.0 ; Web 3.0 ; authoring tool ; web-based-training ; virtual microscope ; virtual education ; virtual term ; selection procedure ; bed-side-teaching ; participatory-design ; study course ; university training course ; certificate e-Learning ; VMC ; Virtueller Medizinischer Campus ; e-Learning ; eLearning ; Lerninformationssystem ; Universität ; Medizinische Universität Graz ; neue Medien ; neue Medien in der Lehre ; Blended Learning ; Repository ; Web 2.0 ; Web 3.0 ; Autorentool ; web-based-Training ; virtuelles Mikroskop ; virtuelle Lehre ; virtuelles Semester ; Auswahlverfahren ; bed-side-teaching ; Participatory-Design ; Studiengang ; Universitätslehrgang ; Zertifikat e-Learning ; ddc: 610
    Language: German
    Type: article
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  • 5
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    Keywords: COMBINATION ; Germany ; SYSTEM ; COHORT ; DISEASE ; MORTALITY ; GENE ; PATIENT ; CONTRAST ; FREQUENCY ; FREQUENCIES ; PLASMA ; AGE ; WOMEN ; MUTATION ; MEN ; arteries ; MUTATIONS ; pathology ; PREVALENCE ; proteinuria ; VESSELS ; STROKE ; YOUNG ; ADULT ; ADULTS ; ENZYME-ACTIVITIES ; ENZYME ; methods ; age of onset ; prospective ; sequencing ; prospective study ; CRYPTOGENIC STROKE ; YOUNG-ADULTS ; DEFICIENT ; female ; HIGH-FREQUENCIES ; ISCHEMIC STROKE ; Male ; ONSET ; PEOPLE
    Abstract: Background Strokes are an important cause of morbidity and mortality in young adults. However, in most cases the cause of the stroke remains unclear. Anderson-Fabry disease is an X-linked recessive lysosomal storage disease resulting from the deficient alpha-galactosidase and causes an endothelial vasculopathy followed by cerebral ischaemia. To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients. Methods Between February, 2110, and December, 2004 721 German adults aged 18 to 55 years suffering from acute cryptogenic stroke were screened for Fabry disease. The plasma alpha-galactosidase activity in men was measured followed by sequencing of the entire alpha-GAL gene in those with low enzyme activity. By contrast, the entire alpha-GAL gene was genetically screened for mutations in women even if enzyme activity was normal. Findings 21 of 432 (4.9%) male stroke patients and seven of 2879 (2.4%) women had a biologically significant mutation within the alpha-GAL gene. The mean age of onset of symptomatic cerebrovascular disease was 38.4 years (SD 13.0) in the male stroke patients and 40.3 years (13.1) in the female group. The higher frequency of infarctions in the vertebrobasilar area correlated with more pronounced changes in the vertebrobasilar vessels like dolichoectatic pathology (42.9% vs 6.8%). Interpretation We have shown a high frequency of Fabry disease in a cohort of patients with cryptogenic stroke, which corresponds to about 1.2% in young stroke patients. Fabry disease must be considered in all cases of unexplained stroke in young patients, especially in those with the combination of infarction in the vertebrobasilar artery system and proteinuria
    Type of Publication: Journal article published
    PubMed ID: 16298216
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  • 7
    Abstract: We evaluated a multiple consanguineous Turkish family with two children, a boy and a girl, affected by severe encephalopathy, hypotonia, microcephaly and retinal dystrophy by a combination of linkage analysis and Whole Exome Sequencing (WES). We analyzed the sequence data by two different bioinformatics pipelines which did not differ in overall processing strategy but involved differences in software used, minor allele frequency (MAF) thresholds and reference data sets, the usage of in-house control exomes and filter settings to prioritize called variants. Assuming autosomal recessive mode of inheritance, only homozygous variants present in both children were considered. The resulting variant lists differed partially (nine variants identified by both pipelines, ten variants by only one pipeline). Major reasons for this discrepancy were different filters for MAF and different variant prioritizations. Combining the variant lists with the results of linkage analysis and further prioritization by expression data and prediction tools, an intronic homozygous splice variant (c.1090-2A〉G; IVS9-2A〉G; p.?) in PGAP1 (Post-GPI Attachment To Proteins 1) was identified and validated by cDNA analysis. PGAP1 ensures the first step of maturation of GPI (glycosylphosphatidylinositol)-anchor proteins. Recently, a homozygous loss-of-function mutation in PGAP1 has been reported in one family with two children affected by a similar phenotype. The present report not only illustrates the possible influence of specific filtering settings on the results of WES but also confirms PGAP1 as a cause of severe encephalopathy.
    Type of Publication: Journal article published
    PubMed ID: 26050939
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  • 8
    Abstract: BACKGROUND & AIMS: We report a novel experimental immunotherapeutic approach in a patient with metastatic intrahepatic cholangiocarcinoma. In the 5year course of the disease, the initial tumor mass, two local recurrences and a lung metastasis were surgically removed. Lacking alternative treatment options, aiming at the induction of anti-tumor T cells responses, we initiated a personalized multi-peptide vaccination, based on in-depth analysis of tumor antigens (immunopeptidome) and sequencing. METHODS: Tumors were characterized by immunohistochemistry, next-generation sequencing and mass spectrometry of HLA ligands. RESULTS: Although several tumor-specific neo-epitopes were predicted in silico, none could be validated by mass spectrometry. Instead, a personalized multi-peptide vaccine containing non-mutated tumor-associated epitopes was designed and applied. Immunomonitoring showed vaccine-induced T cell responses to three out of seven peptides administered. The pulmonary metastasis resected after start of vaccination showed strong immune cell infiltration and perforin positivity, in contrast to the previous lesions. The patient remains clinically healthy, without any radiologically detectable tumors since March 2013 and the vaccination is continued. CONCLUSIONS: This remarkable clinical course encourages formal clinical studies on adjuvant personalized peptide vaccination in cholangiocarcinoma. LAY SUMMARY: Metastatic cholangiocarcinomas, cancers that originate from the liver bile ducts, have very limited treatment options and a fatal prognosis. We describe a novel therapeutic approach in such a patient using a personalized multi-peptide vaccine. This vaccine, developed based on the characterization of the patient's tumor, evoked detectable anti-tumor immune responses, associating with long-term tumor-free survival.
    Type of Publication: Journal article published
    PubMed ID: 27397612
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  • 9
  • 10
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 7; DOC25 /20070921/
    Publication Date: 2007-09-22
    Keywords: ddc: 610
    Language: German
    Type: article
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