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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  29. Jahrestagung der Retinologischen Gesellschaft; 20160617-20160618; Berlin; DOC16rg16 /20160616/
    Publication Date: 2016-06-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Abstract: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) comprise approximately 15% of all childhood malignancies. Cure rates for both lymphoma entities have evolved tremendously during the last couple of decades, raising the 5-year survival rates to almost 100% for HL and to 85% for NHL. The mainstay therapy for both malignancies is still chemotherapy-with different regimens recommended for different types of disease. In HL, combined modality treatment, i.e., chemotherapy followed by radiotherapy, has long been the standard regimen. In order to reduce long-term side effects, such as second malignancies, most major pediatric HL consortia have studied response-based radiotherapy reduction strategies over the last 3 decades. For recurrent disease, high-dose chemotherapy followed by an autologous or an allogeneic hematopoietic stem-cell transplant is an option. No targeted agents have yet gained regulatory approval for use in pediatric patients with lymphoma. For adult lymphoma patients, the CD20 antibody rituximab and the CD30 antibody-drug conjugate brentuximab vedotin are targeted agents used regularly in first- and second-line treatment regimens. More recently, immune checkpoint inhibitors, phosphatidyl-inositol-3-kinase inhibitors, and Bruton's tyrosine kinase inhibitors appear to be very promising new treatment options in adult lymphoma. Here, we discuss the current experience with these types of agents in pediatric lymphoma patients.
    Type of Publication: Journal article published
    PubMed ID: 29127674
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW; VOL: 6; DOC05 /20170323/
    Publication Date: 2017-03-23
    Description: The aim of this study was to measure line segments and areas of sella turcica on lateral cephalograms with respect to the clinical diagnosis of facial phenotype of patients with neurofibromatosis type 1 (NF1). Special attention was given to correlate the measured values with certain tumour types that are typical for this disease.Material and methods: Lateral cephalograms of 194 individuals were investigated. Patients with NF1 were further divided according to the detection and topography of facial plexiform neurofibromas (PNF) taking into account the distribution pattern of the trigeminal nerve. All patients with PNF showed unilateral tumour localisation. Patients without any facial PNF constituted a separate group. Healthy volunteers with ideal occlusion and no history of any intervention in the maxillofacial region served as a control group. The following items were determined on the radiographs: sella entrance, sella width, sella depths, sella diagonal, and sella area.Results: Patients with PNF of the first and second trigeminal nerve branch or affected in all branches showed highly statistically significant enlarged sella tucica measurement values. On the other hand, patients with PNF restricted to one branch only or simultaneously in the second and third branches showed measurement values that were not different to those obtained in NF1 patients devoid of facial PNF. The latter group also showed no difference of sella turcica parameters obtained in the control group.Conclusion: This study provides evidence for the association of a certain NF1 phenotype with distinct skeletal alterations of the skull base, shown here using the example of the representation of the sella turcica in the lateral radiograph. These findings are also relevant in the discussion of NF1 as a disease of bones and in the assessment of brain development in NF1. Both items are discussed in relationship to a facial plexiform neurofibroma. Furthermore, the knowledge of this association of findings provides the clinician with relevant information in the planning of skull base procedures in these patients.
    Description: Das Ziel dieser Untersuchungen war die Vermessung von Strecken und Flächen der Sella turcica auf seitlichen Fernröntgenbildern unter besonderer Berücksichtigung des fazialen Phänotyps von Patienten, die an einer Neurofibromatose Typ 1 (NF1) erkrankt waren. Besondere Aufmerksamkeit wurde der Korrelation von definierten Tumortypen, die für diese Erkrankung typisch sind, und den kephalometrischen Messwerten gewidmet.Material und Methode: Laterale Kephalogramme von 194 Individuen wurden untersucht. Patienten mit NF1 wurden weiter differenziert nach dem Nachweis und der Topographie fazialer plexiformer Neurofibrome (PNF), wobei das Verteilungsmuster des N. trigeminus im Gesicht als Orientierung diente. Alle Patienten mit PNF hatten eine einseitige Manifestation des Tumors. Patienten ohne faziales PNF stellten eine gesondert analysierte Gruppe dar. Gesunde Probanden mit Idealokklusion und ohne jede Vorgeschichte einer Intervention im kraniomaxillofazialen Bereich dienten als Kontrollgruppe. Die folgenden Messungen wurden durchgeführt: Sella-Eingang, Sella-Weite, Sella-Tiefe, Sella-Diagonale und Sella-Fläche.Ergebnisse: Patienten mit einem PNF des ersten und zweiten oder solche, die in allen drei Ästen des N. trigeminus von diesem Tumor betroffen sind, weisen statistisch signifikant vergrößerte Sella-Messwerte auf. Andererseits sind die Messwerte der Patienten, die nur in einem einzelnen Ast vom PNF betroffen sind oder deren Tumorausbreitung sich auf den 2. und 3. Ast des Nervs beschränkt, von denen der Patienten ohne ein faziales PNF statistisch nicht zu unterscheiden. Die Messwerte dieser beiden Gruppen unterscheiden sich ebenfalls nicht von denen der Kontrollgruppe. Schlussfolgerung: Diese Untersuchung beweist die Assoziation eines bestimmten Ausbreitungstyps des fazialen PNF bei NF1-Patienten mit merklichen skelettalen Veränderungen der Schädelbasis, hier dargestellt anhand der Form der Sella turcica im seitlichen Röntgenbild. Diese Befunde sind auch bedeutsam für die Diskussion der NF1 als Erkrankung des Skelettsystems und für die Einschätzung der Gehirnentwicklung bei NF1, beide in Zusammenhang mit dem Nachweis eines plexiformen Neurofibroms. Weiterhin liefern die Kenntnisse über die hier vorgestellten Befunde dem Kliniker relevante Informationen für die Planung von Schädelbasiseingriffen an Patienten mit dieser Diagnose.
    Keywords: neurofibromatosis type 1 ; sella turcica ; plexiform neurofibroma ; trigeminal nerve ; cephalometry ; skull base surgery ; anthropology ; Neurofibromatose Typ 1 ; Sella turcica ; plexiformes Neurofibrom ; Nervus trigeminus ; Kephalometrie ; Schädelbasis-Chirurgie ; Anthropologie ; ddc: 610
    Language: English
    Type: article
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  • 4
    ISSN: 1432-0878
    Keywords: ACTH cells ; Immunocytochemistry ; Morphometry ; Spontaneous hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary ACTH-immunoreactive cells in the anterior pituitary of 4-week-old spontaneously hypertensive rats (SHR) were studied with immunocytochemical and morphometric techniques. The results were compared with data from age-matched normotensive Wistar-Kyoto rats (WKY). No significant differences were found in volume density and average size of ACTH-immunoreactive cells between these two strains. However, SHR showed a significantly larger anterior lobe (2 P 〈 0.01) than WKY, indicating that the total number of ACTH-immunoreactive cells in the anterior pituitary is greater in SHR than in WKY. These data are in agreement with radioimmunological determinations showing a significantly elevated content (2 P 〈 0.01) but only a moderately higher concentration (0.05 〈 2 P 〈 0.10) of ACTH in the anterior pituitary of SHR as compared to WKY. The present results suggest an enhanced availability of ACTH in the anterior pituitary of 4-week-old SHR, a fact which could explain the markedly enhanced stress-induced release of ACTH previously found in these animals. This study further supports the hypothesis that, among other factors, an instability of the hypothalamo-pituitary-adrenal axis may contribute to the development of genetically programmed hypertension.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nondestructive evaluation 3 (1982), S. 111-113 
    ISSN: 1573-4862
    Keywords: photoacoustic microscopy ; delamination ; layered structure ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An adhesive layer, by which a piezoceramic foil is attached to an aluminum membrane for telephone application, is examined in a nondestructive way by thermal waves. The basic principles of the method are outlined, and its detecting power is demonstrated by evaluation of a well-defined delamination.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 284 (1956), S. 662-666 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 295 (1960), S. 414-421 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 16 (1957), S. 9-10 
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Der Referent erörtert an Hand elektronenoptischer Beobachtungen morphologische Probleme. Diese kommen als Basis immer zuerst. Leider sind die gleichen Nervenfasern nicht immer am selben Platz. Es gibt drei bis fünf Arten von sympathischen Fasern; das Silber präzipitiert sich bei der Imprägnation im Innern, nicht an der Oberfläche. Der „nerf pulmonaire” dient als Testnerv. Selbst im Mikroskop lassen sich Vagus und Sympathicus nicht separieren. Es wird noch großer Anstrengung bedürfen, um die Synapsen und das Endnetz aufzuklären.
    Type of Medium: Electronic Resource
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