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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  16. Jahreskongress für Klinische Pharmakologie; 20141009-20141010; Köln; DOC14vklipha13 /20140925/
    Publication Date: 2014-09-25
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    Keywords: RECEPTOR ; CANCER ; EXPRESSION ; GROWTH ; proliferation ; tumor ; CELL ; Germany ; MICROSCOPY ; THERAPY ; CLASSIFICATION ; FOLLOW-UP ; SUPPORT ; HISTORY ; DISTINCT ; GENE ; HYBRIDIZATION ; PROTEIN ; DIFFERENTIATION ; TUMORS ; SURGERY ; TIME ; PATIENT ; COMPARATIVE GENOMIC HYBRIDIZATION ; COPY NUMBER ; MALIGNANCIES ; MEMBRANE ; NUMBER ; AGE ; RECURRENCE ; vimentin ; pathology ; IMBALANCES ; MOLECULAR-CLONING ; LACKING ; FEATURES ; MALIGNANCY ; ELECTRON-MICROSCOPY ; HIGH-RESOLUTION ; GLIOMA ; analysis ; TUMOR-CELL ; USA ; LOSSES ; PHOSPHATASE ; epilepsy ; genomic ; RARE ; NECROSIS ; IMMUNOREACTIVITY ; CHROMOSOME-6 ; angiocentric ; NEUROFIBRILLARY TANGLES ; TANYCYTIC EPENDYMOMA
    Abstract: Angiocentric glioma has recently been described as a novel epilepsy associated tumor with distinct clinico-pathologic features. We report the clinical and pathologic findings in 8 additional cases of this rare tumor type and extend its characterization by genomic profiling. Almost all patients had a history of long-standing drug-resistant epilepsy. Cortico-subcortical tumors were located in the temporal and parietal lobes. Seizures began at 3 to 14 years of age and surgery was performed at 6 to 70 years. Histologically, the tumors were characterized by diffuse growth and prominent perivascular tumor cell arrangements with features of astrocytic/ependymal differentiation, but lacking neoplastic neuronal features. Necrosis and vascular proliferation were not observed and mitoses were sparse or absent. M1B-1 proliferation indices ranged from 〈 1% to 5%. Immunohistochemically, all cases stained positively for glial fibrillary acidic protein, vimentin, protein S100B, variably for podoplanin, and showed epithelial membrane antigen-positive cytoplasmic dots. Electron microscopy showed ependymal characteristics in 2 of 3 cases investigated. An analysis of genomic imbalances by chromosomal comparative genomic hybridization revealed loss of chromosomal bands 6q24 to q25 as the only alteration in I of 8 cases. In I of 3 cases, a high-resolution screen by array-comparative genomic hybridization identified a copy number gain of 2 adjacent clones from chromosomal band 11p11.2 containing the protein-tyrosine phosphatase receptor type J (PTPRJ) gene. All patients are seizure free and without evidence of tumor recurrence at follow-up times ranging from 1/2 to 6.9 years. Our findings support 2 previous reports proposing that angiocentric glioma is a novel glial tumor entity of low-grade malignancy
    Type of Publication: Journal article published
    PubMed ID: 18059228
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  • 3
  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  51. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 20060910-20060914; Leipzig; DOC06gmds019 /20060901/
    Publication Date: 2006-09-25
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds058 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
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    German Medical Science; Düsseldorf, Köln
    In:  Kooperative Versorgung - Vernetzte Forschung - Ubiquitäre Information; 49. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 19. Jahrestagung der Schweizerischen Gesellschaft für Medizinische Informatik (SGMI) und Jahrestagung 2004 des Arbeitskreises Medizinische Informatik (ÖAKMI) der Österreichischen Computer Gesellschaft (OCG) und der Österreichischen Gesellschaft für Biomedizinische Technik (ÖGBMT); 20040926-20040930; Innsbruck; DOC04gmds083 /20040914/
    Publication Date: 2004-09-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
    Publication Date: 2018-03-23
    Description: Objectives To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. Design A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. Participants A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands. Results The overall prevalence of PIP was lower in the Irish participants (8.7%) compared with the Swiss (16.7%) and Dutch (12.5%) participants (P=0.15) and was not statistically significant. The overall prevalence of PPOs was approximately one-quarter in the Swiss (25.3%) and Dutch (24%) participants and lower in the Irish (14%) participants (P=0.04) and the difference was statistically significant. The hypnotic Z-drugs were the most frequent PIP in Irish participants, (3.5%, n=4), while it was non-steroidal anti-inflammatory drug and oral anticoagulant combination, sulfonylureas with a long duration of action, and benzodiazepines (all 4.3%, n=7) in Swiss, and benzodiazepines (7.1%, n=18) in Dutch participants. The most frequent PPOs in Irish participants were vitamin D and calcium in osteoporosis (3.5%, n=4). In the Swiss and Dutch participants, they were bone antiresorptive/anabolic therapy in osteoporosis (9.9%, n=16, 8.6%, n=22) respectively. The odds of any PIP after adjusting for age, sex, multimorbidity and polypharmacy were (adjusted OR (aOR)) 3.04 (95% CI 1.33 to 6.95, P〈0.01) for Swiss participants and aOR 1.74 (95% CI 0.79 to 3.85, P=0.17) for Dutch participants compared with Irish participants. The odds of any PPOs were aOR 2.48 (95% CI 1.27 to 4.85, P〈0.01) for Swiss participants and aOR 2.10 (95% CI 1.11 to 3.96, P=0.02) for Dutch participants compared with Irish participants. Conclusions This study has estimated and compared the prevalence and type of PIP and PPOs among this cohort of community-dwelling older people. It demonstrated a significant difference in the prevalence of PPOs between the three populations. Further research is urgently needed into the impact of system level factors as this has important implications for patient safety, healthcare provision and economic costs.
    Keywords: Open access, Pharmacology and therapeutics
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 37 (1997), S. 410-416 
    ISSN: 1432-2102
    Keywords: Key words Electron-beam computed tomography • Coronary artery disease • Myocardial perfusion ; Schlüsselwörter Electron-beam-Computertomographie • Koronare Herzerkrankung • Myokardiale Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die kurzen Expositionszeiten von 100 oder 50 ms/Scan und die gleichzeitige schnelle Bildfolge, die mittels Electron-beam-Computertomographie erreicht werden können, ermöglichen auch Untersuchungen an bewegten Organen, wie z. B. dem Herzen. Hierbei können nahezu alle morphologischen und funktionellen Determinanten des Herzens während einer einzigen Untersuchung von ca. 40 min bestimmt werden. An einzelnen akuten und chronischen Erkrankungen werden die Möglichkeiten des EBCT bei der Bestimmung des Koronarkalziumscores, der myokardialen Perfusion, der linksventrikulären Volumina und der Morphologie der Koronargefäße dargestellt. Es scheint, daß die Bestimmung dieser kardialen Determinanten einen wichtigen Beitrag zur Früherkennung kardialer Dysfunktionen ermöglicht und zur hämodynamischen Beurteilung der Bedeutung von Koronargefäßstenosen beitragen wird. Systematische Untersuchungen und eine interdisziplinäre Zusammenarbeit ist erforderlich, um den Stellenwert dieser neuen, vielversprechenden und auf dem Gebiete der Computertomographie zukunftsweisenden Technologie zu bestimmen.
    Notes: Summary Using electron-beam computed tomography (EBCT) with short exposure times of 100 or 50 ms and the capability of acquiring up to 2 × 17 images/s it is possible to study most of the important morphological and functional determinants of the heart. Various examples of studies in acute and chronic cardiac diseases are shown to demonstrate the use of EBCT to determine quantitatively left ventricular volumes (ml), myocardial mass (g), wall thickness changes over the cardiac cycle (mm/s), myocardial perfusion (ml/100 g/min) and the extent of coronary calcification (calcium score) and qualitatively the state of the proximal 4–6 cm of the subepicardial coronary arteries. The knowledge of these determinants seems very useful in excluding cardiac dysfunction, in the early recognition of cardiac disease and in the evaluation of the haemodynamic severity of coronary artery stenotic lesions. Further interdisciplinary studies are necessary to assess the clinical validity of these cardiac determinants, especially myocardial perfusion, using this advanced CT technology.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1076
    Keywords: HIV infections ; Infant newborn ; Pregnancy ; Parity ; Caesarean section
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract In a national prospective study of risk factors for mother-tochild transmission of human immunodeficiency virus (HIV), 316 children of HIV-positive mothers were followed up for at least 6 months. Infection status was determined in 254 of them and 46 were found to be infected giving a transmission rate of 18.1%. Univariate analysis of potential risk factors for mother-to-child transmission showed an association between primiparity and increased transmission rate: odds ratio 2.2, 95% confidence interval (CI) 1.1–4.6,P〈0.05. Analysis by logistic regression confirmed this association (adjusted odds ratio 2.4) and showed, in addition, a negative association between transmission rate and elective Caesarean section (adjusted odds ratio 0.36, 95% CI 0.13–0.97,P〈0.05). The effect of primiparity was less pronounced in combination with elective Caesarean section (odds ratio 1.7) than with other delivery modes (odds ratio 2.5, difference not significant. HIV-infected children were less likely to experience the birth of a younger sibling during the observation period than their uninfected counterparts (2 of 46 vs 27 of 208,P〈0.05 by logrank test). Conclusions Primiparous women appear to transmit HIV to their children at a higher rate. This could be explained by increased intrapartum transmission because of longer and more complicated labour in primiparas and/or by a self-selection of women with lower risk of transmission among those deciding to have additional children.
    Type of Medium: Electronic Resource
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