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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds114 /20110920/
    Publication Date: 2011-09-20
    Keywords: Mortalität ; Chemische Industrie ; Dioxin ; Follow-up ; betriebliche Epidemiologie ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
  • 3
    facet.materialart.
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds234 /20070906/
    Publication Date: 2007-09-07
    Keywords: Berufsasthma ; Gender ; Prävention ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    ISSN: 1432-0738
    Keywords: Key words Styrene ; Styrene-7 ; 8-oxide ; Human white blood cells ; 8-Hydroxy-2′-deoxyguanosine ; Oxidative DNA damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Styrene-7,8-oxide (SO), the major in vivo metabolite of styrene, is a genotoxic compound and a potential carcinogenic hazard to occupationally exposed workers. The aim of the present work was to investigate the ability of styrene exposure to induce formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in white blood cells (WBC) of boatbuilders occupationally exposed to styrene. The study of these adducts was conducted to see if styrene exposure can cause oxidative damage of DNA. The 8-OHdG/105 dG ratio from 17 styrene-exposed workers showed significant increases (mean ± SD, 2.23 ± 0.54, median 2.35, P 〈 0.001) in comparison to the controls (1.52 ± 0.45, median 1.50). However, 11 out of 17 workers who were between the ages of 32 and 60 years and had been occupationally exposed to styrene for 〉10 years showed higher 8-OHdG/105 dG ratios (2.31 ± 0.62, median 2.37) in comparison to 6 workers with 〈6 years of occupational styrene-exposure (2.11 ± 0.36, median 2.05; P 〉 0.05, no significant difference between the two groups of workers). The studies presented here provide an indication that styrene exposure can result in oxidative DNA damage.
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  • 5
    ISSN: 1432-1246
    Keywords: Key words Lung function ; Spirometry ; Body plethysmography ; Recommendation ; Reference values
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Lung-function reference values play an important role in medical surveillance examinations of occupational and environmental respiratory diseases, in stipulation of preventive measures, in initiation of therapeutic measures, and in granting of benefits to which individuals with lung injuries or occupational lung diseases are entitled (e.g., bronchial asthma, pneumoconiosis, or farmer's lung disease). Prediction equations most widely used are based on studies performed more than 20 years ago and may not represent the findings obtained in today's population. Methods: We recorded case histories and lung function values of 139 healthy subjects (spirometric and plethysmographic data, TLCO) and computed the differences of measured values minus predicted ones as recommended by different authors. Results: The means of these differences can be seen as shifts in our group versus the theoretical (predicted) values of various authors. These shifts, the standardized mean values of residuals, and their probability as determined under the assumptions of the respective regression model and the number of subjects below the threshold limits are given. FVC, FEV1, and FEV1%FVC show mostly good agreement with the recommendations by Crapo et al., Roca et al., Glindmeyer et al., Brändli et al., and Berger et al. Our IVC and FVC values do not differ significantly from each other. Normative flow-volume curve parameters of various authors deviate widely, however, and are not compatible with the values of our control group. Plethysmographically measured volumes (FRC, TLC, and RV) are only insufficiently reflected by Quanjer's reference equations. Measured TLCO and KCO show good agreement with the predictions of Cotes et al. [11] for females but display less concurrence with the predictions for males. Conclusions: Our results indicate that the ERS values of FVC, FEV1, and FEV1%FVC mainly applied in Europe should be verified. The much better-evaluated formulas of Brändli et al. are recommended. Furthermore, the age range between 60 and 70 years should be extrapolated from these formulas until better epidemiological data on lung function are available.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Latexallergie ; Latexproteine ; Kreuzallergene ; HLA-Assoziation ; Prophylaxe ; Key words Latex allergy ; Latex proteins ; Crossreacting fruits ; HLA-association ; Prophylaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During the last ten years better hygienic standards led to an increased use of natural latex gloves for protection of medical staff. During this time reports about an IgE mediated allergy to latex up to life-threatening anaphylactic reactions came up. This allergy was different from the known type IV reactions on latex additives. Health care workers and patients with multiple surgery were identified as high risk groups. For unknown reasons patients with spina bifida show the highest prevalence of latex-specific IgE antibodies. A preexisting atopy increases the risk of latex sensitization. Allergic reactions are caused mainly by medical treatments, especially surgery, when latex gloves and other latex containing articles are used. Allergenic proteins: Meanwhile some allergenic proteins in latex could be identified. Patients in different risk groups showed different prevalences of sensitization to these allergens. The way of allergen uptake (aerogen or by intraoperative direct mucosal contact) may play an important role in sensitization to different allergens. Some allergens like Hev b 1, Hev b 3, Hev b 6.02 habe been totally or partially sequenced; on Hev b 1 molecule several IgE binding epitopes have been localized. T lymphocytes could be estimated by latex proteins. There is an association between the HLA antigens DR4 and DQ8 and the specific IgE response to the latex allergen Hev b 6.02, in contrast no significant association was observed between the IgE response to Hev b 1 and HLA class II alleles. Crossreacting antibodies between latex and numerous tropical fruits are described. For some proteins structural homologies are well characterized. Diagnosis: For the diagnosis of latex allergy serologic tests (for instance the CAP system) are available. Latex protein extracts for skin prick tests are difficult to standardize. Prophylaxis: For high risk patients a primary prophylaxis is recommended, a secondary or tertiary prophylaxis allows safe operations without symptoms of latex allergy.
    Notes: Zusammenfassung Im zeitlichen und wahrscheinlichen auch ursächlichem Zusammenhang mit dem steigenden Verbrauch von Latexhandschuhen wurde neben den schon bekannten Typ-IV-Allergien auf Zusatzstoffe des Latex auch über IgE vermittelte Typ-I-Sofortreaktionen bis zu lebensbedrohlichen anaphylaktischen Reaktionen berichtet. Als besondere Risikogruppen wurden neben medizinischem Personal Patienten mit multiplen Voroperationen identifiziert. Von ihnen haben aus noch nicht näher bekannten Gründen Patienten mit Spina bifida die höchsten Prävalenzen. Eine vorbestehende Atopie erhöht das Risiko der Latexsensibilisierung. Allergische Reaktionen auslösende Situationen sind v. a. bei medizinischen Maßnahmen verschiedenster Art gegeben, in denen Latexhandschuhe und andere Latexartikel verwendet werden. Allergene: Inzwischen konnten mehrere allergene Proeine im Latex identifiziert werden, die in unterschiedlicher Häufigkeit Risikogruppen sensibilisieren, wobei auch der Weg der Allergenaufnahme (aerogen, durch direkten intraoperativen Schleimhautkontakt) eine Rolle spielen dürfte. Einzelne Allergene (z. B. Hev b 1, Hev b 3, Hev b 6.02) wurden ganz oder teilweise sequenziert, für Hev b 1 liegen bereits Analysen der IgE-Bindungsstellen vor. Auch T-Zell-Stimulationsexperimente wurden mit einzelnen Proteinen erfolgreich durchgeführt. Die Assoziation der IgE-Antwort auf Hev b 6.02 mit den HLA-Antigenen DR4 und DQ8 konnte gesichert werden, eine signifikante Assoziation zwischen der IgE-Antwort auf Hev b 1 und dem HLA-System war nicht zu finden. Kreuzreagierende Antikörper sind zwischen Latex und zahlreichen exotischen Früchten beschrieben worden, deren Allergenhomologien z. T. bereits gut charakterisiert sind. Diagnose: Zur Diagnose der Latexallergie stehen z. Z. serologische Tests (z. B. CAP-System) und wenige schwer zu standardisierende Hauttests zur Verfügung. Prophylaxe: Bei Hochrisikopatienten wird erfolgreich eine primäre Prophylaxe angewandt, auch eine sekundäre oder tertiäre Prävention ermöglicht Operationen ohne Symptome der Latexallergie.
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  • 8
    ISSN: 1433-8491
    Keywords: Emery-Dreifuss syndrome ; Autosomal dominant inheritance ; Single-fiber EMG ; Fiber type-I atrophy ; Spinal muscular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The first German family with autosomal dominant Emery-Dreifuss syndrome (EDS) is described, with electrophysiologic and myopathologic results providing evidence of a primary neurogenic disease. According to classification of the scapulo peroneal syndrome without cardiomyopathy, we conclude that there are two variants of EDS: one myopathic, the other neurogenic in origin. Therefore, the term Emery-Dreifuss muscular dystrophy should be avoided. Instead, each case of EDS should be classified as myopathic or neurogenic with X chromosome recessive or autosomal dominant inheritance.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 45 (1996), S. 653-656 
    ISSN: 1432-055X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent studies have demonstrated that allergy to natural rubber latex (NRL) is associated with cross-reactivity to certain foods. The aim of this study was to investigate the prevalence of NRL sensitization and allergy in children with atopic dermatitis (n=74). We also examined cross-reactions between latex and foods, and compared the frequency of suspected latex cross-reacting fruits in children with and without NRL-specific immunoglobulin E (IgE). Twelve of the 74 atopic children studied (16.2%; 95% confidence interval (CI), 8.7–26.6%) had circulating IgE antibodies to latex. These NRL-sensitized children were older and they showed significantly higher total IgE values (p〈0.003) when compared with the group of children without NRL sensitization. Of the specific food IgE evaluations, 18.4% (93 out of 505) were positive, and 69.9% were observed in the group of children with latex-specific IgE, most frequently to potato, tomato, sweet pepper, and avocado. An isolated latex-specific IgE response without food-specific IgE was never observed. Exclusively in the latex-positive group, conformity with the report of allergic symptoms after ingestion of food and increased food-specific IgE was found. Twenty children without proven latex sensitization showed increased food-specific IgE, most frequently to potato, banana, and chestnut. Avocado-specific IgE was never determined in this patient group. No significant differences were detected concerning the sensitization to potato, banana, and kiwi between NRL-sensitized children and the group of 20 children without latex-specific IgE. The competitive CAP inhibition using sera from children with specific IgE to both latex and food showed different cross-reactivities between latex and the specific food. A close relationship existed between latex and avocado (median inhibition: 100%), whereas sensitization to latex and kiwi seemed to be independent in our study group (inhibition: 〈25%). In particular, for potato, cross-reactivity and co-sensitization existed. Our study demonstrated that children with atopic dermatitis are a high-risk group for latex sensitization. Increasing age, additional sensitization to ubiquitous inhaled allergens, and enhanced total serum IgE values seemed to be important variables for latex sensitization and further sensitization to the latex-associated foods. Cross-reactivity and, in some cases, co-sensitization to specific fruits and vegetables, were observed.
    Type of Medium: Electronic Resource
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