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  • 1
    Call number: ZZ1973:4/1 ; ZZ1973:4/2 ; ZZ1973:4/3
    Keywords: Computer graphics ; DKFZ-publications
    Pages: 3 vol.
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds386 /20070906/
    Publication Date: 2007-09-07
    Keywords: postmenopausal breast cancer risk ; menopausal hormone therapy use ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Publication Date: 2006-08-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  127. Kongress der Deutschen Gesellschaft für Chirurgie; 20100420-20100423; Berlin; DOC10dgch301 /20100517/
    Publication Date: 2010-05-17
    Keywords: ddc: 610
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  • 5
    Keywords: CANCER ; Germany ; THERAPY ; INFORMATION ; DISEASE ; RISK ; validation ; BREAST ; breast cancer ; BREAST-CANCER ; NO ; hormone ; HEALTH ; DESIGN ; NUMBER ; AGE ; HORMONE REPLACEMENT THERAPY ; cancer risk ; REGION ; REGIONS ; RELIABILITY ; case-control studies ; BREAST-CANCER RISK ; POSTMENOPAUSAL WOMEN ; breast neoplasms ; case control study ; case-control study ; RE ; DETERMINANTS ; THERAPIES ; RECALL ; ESTROGEN ; case control studies ; INTERVAL ; RANDOMIZED CONTROLLED-TRIAL ; REPLACEMENT THERAPY ; correlation ; population-based ; CANCER-RISK ; AGREEMENT ; case control ; postmenopausal ; comparison ; validation studies ; prescription ; ESTROGEN REPLACEMENT THERAPY ; postmenopause ; RECORDS
    Abstract: Objective: In a population-based case-control study examining the effects of postmenopausal hormone therapy (HT) on breast cancer risk, the authors conducted a validation study comparing prescription data from gynecologists with self-reports. Study Design and Setting: The study was conducted in the Rhein-Neckar and Hamburg regions of Germany from 2002 to 2005. A total of 224 cases and 225 controls, stratified by region, age, and hormone use were randomly selected for the validation study. Results: For ever/never use 88.2% agreement was seen, and agreement for ever/never use by type of HT was 80.6%, 80.3%, and 90.5% for mono-estrogen, cyclical combined, and continuous combined therapy, respectively. The intraclass correlation coefficient (ICC) for duration of use was high, 0.82 (95% confidence interval [CI]: 0.77, 0.85), as were the ICCs for age at first and last use, 0.88 (95% CI: 0.85, 0.91) and 0.98 (95% CI: 0.97, 0.98). Despite the exceptionally high number of different HT prescriptions available in Germany, comparison of exact brand name resulted in perfect agreement for 50.2% of participants, partial agreement for 29.3%, and no agreement for 20.7%. In general, agreement was not differential by disease status. Conclusion: Overall, the self-reported HT of the study participants corresponded well with physicians' reports. (C) 2007 Elsevier Inc. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17998083
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  • 6
    Keywords: LUNG ; BREAST-CANCER ; PROGRESSION ; METASTASIS ; PROGNOSTIC VALUE ; RECONSTRUCTION ; COLORECTAL-CARCINOMA ; EPITHELIAL-MESENCHYMAL TRANSITION ; CIRCULATING TUMOR-CELLS ; SERIAL SECTIONS
    Abstract: Cancer cell invasion takes place at the cancer-host interface and is a prerequisite for distant metastasis. The relationships between current biological and clinical concepts such as cell migration modes, tumour budding and epithelial-mesenchymal transition (EMT) remains unclear in several aspects, especially for the 'real' situation in human cancer. We developed a novel method that provides exact three-dimensional (3D) information on both microscopic morphology and gene expression, over a virtually unlimited spatial range, by reconstruction from serial immunostained tissue slices. Quantitative 3D assessment of tumour budding at the cancer-host interface in human pancreatic, colorectal, lung and breast adenocarcinoma suggests collective cell migration as the mechanism of cancer cell invasion, while single cancer cell migration seems to be virtually absent. Budding tumour cells display a shift towards spindle-like as well as a rounded morphology. This is associated with decreased E-cadherin staining intensity and a shift from membranous to cytoplasmic staining, as well as increased nuclear ZEB1 expression.
    Type of Publication: Journal article published
    PubMed ID: 25081610
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Krankenhaushygiene Interdisziplinär; VOL: 6; DOC14 /20111215/
    Publication Date: 2011-12-16
    Description: Background: Bacterial contamination of anesthesia breathing machines and their potential hazard for pulmonary infection and cross-infection among anesthetized patients has been an infection control issue since the 1950s. Disposable equipment and bacterial filters have been introduced to minimize this risk. However, the machines' internal breathing-circuit-system has been considered to be free of micro-organisms without providing adequate data supporting this view. The aim of the study was to investigate if any micro-organisms can be yielded from used internal machines' breathing-circuit-system. Based on such results objective reprocessing intervals could be defined.Methods: The internal parts of 40 anesthesia machines' breathing-circuit-system were investigated. Chi-square test and logistic regression analysis were performed. An on-site process observation of the re-processing sequence was conducted.Results: Bacterial growth was found in 17 of 40 machines (43%). No significant difference was ascertained between the contamination and the processing intervals. The most common contaminants retrieved were coagulase negative Staphylococci, aerobe spore forming bacteria and Micrococcus species . In one breathing-circuit-system, Escherichia coli , and in one further Staphylococcus aureus were yielded.Conclusion: Considering the availability of bacterial filters installed on the outlet of the breathing-circuit-systems, the type of bacteria retrieved and the on-site process observation, we conclude that the contamination found is best explained by a lack of adherence to hygienic measures during and after re-processing of the internal breathing-circuit-system. These results support an extension of the re-processing interval of the anesthesia apparatus longer than the manufacturer's recommendation of one week. However, the importance of adherence to standard hygienic measures during re-processing needs to be emphasized.
    Description: Hintergrund: Die bakterielle Kontamination von Anästhesiemaschinen und die von Ihnen ausgehende potentielle Gefahr für Pneumonien und Kreuzinfektionen zwischen anästhesierten Patientinnen ist bereits seit den 1950 Jahren ein Thema der Krankenhaushygiene. Um das Risiko einer Kreuzübertragung zu minimieren, wurden Einwegprodukte und Bakterienfilter eingeführt. Soweit gilt der innere Atemkreissystem der Maschinen als frei von Mikroorganismen, ohne dass das jemals mit adäquaten Daten untermauert wurde. Das Ziel der Studie war daher zu untersuchen, ob Mikroorganismen aus dem inneren Kreissystem benutzter Anästhesiemaschinen isoliert werden können. Auf dieser Grundlage könnte man objektive Aufbereitungsintervalle definieren.Methoden: Der innere Kreisteil von 40 Anästhesiemaschinen wurde mikrobiologisch untersucht. Es wurden ein Chi-Quadrat Test und eine logistische Regressionsanalyse durchgeführt. Eine Prozessablaufbeobachtung der Aufbereitung fand vor Ort statt.Ergebnisse: In 17 von 40 Maschinen (43%) wurde Bakterienwachstum festgestellt. Es konnte kein signifikanter Zusammenhang zwischen Kontamination und Aufbereitungsintervallen gefunden werden. Am häufigsten wurden Koagulase negative Staphylokokken, aerobe Sporenbildner und Micrococcus species isoliert. In einem Kreissystem wurde Escherichia coli und in einem anderen Staphylococcus aureus gefunden. Schlussfolgerungen: In Anbetracht der Verwendung von Bakterienfiltern am Maschinenausgang, der isolierten Bakterienspezies und der Prozessablaufbeobachtung vor Ort schließen wir, dass die gefundene Kontamination am besten durch mangelhaft durchgeführte Hygienemaßnahmen während und nach der Aufbereitung der inneren Kreissysteme erklärbar ist. Unsere Ergebnisse befürworten eine Verlängerung der Aufbereitungsintervalle von Kreissystemen, die laut Herstellerangaben wöchentlich erforderlich sind. Grundsätzlich muss die Wichtigkeit von Standardhygienemaßnahmen während der Aufbereitung betont werden.
    Keywords: anesthesia machine ; breathing circuit system ; contamination ; infection control ; Anästhesiemaschinen ; Atemkreissystem ; Kontamination ; Infektionskontrolle ; Krankenhaushygiene ; ddc: 610
    Language: English
    Type: article
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  • 8
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  14. Deutscher Kongress für Versorgungsforschung; 20151007-20151009; Berlin; DOCP143 /20150922/
    Publication Date: 2015-09-23
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 9
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014); 20141028-20141031; Berlin; DOCPO25-122 /20141013/
    Publication Date: 2014-10-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 10
    Keywords: RECEPTOR ; APOPTOSIS ; CANCER ; tumor ; carcinoma ; Germany ; PATHWAY ; PATHWAYS ; THERAPY ; SUPPORT ; LONG-TERM ; RISK ; RISKS ; TUMORS ; BIOMARKERS ; ASSOCIATION ; DISORDER ; BREAST ; breast cancer ; BREAST-CANCER ; hormone ; IN-SITU ; PATTERNS ; HEALTH ; WOMEN ; cancer risk ; CARCINOMAS ; case-control studies ; ER ; ESTROGEN-RECEPTOR ; CYTOTOXICITY ; POSTMENOPAUSAL WOMEN ; DISORDERS ; case control study ; case-control study ; REGRESSION ; THERAPIES ; ESTROGEN ; biomarker ; estrogen receptor ; USA ; phytoestrogens ; SOY INTAKE ; cancer research ; CANCER-RISK ; hormone therapy ; CONFIDENCE ; EXTRACTS ; PROGESTERONE-RECEPTOR ; RECEPTOR STATUS ; BLACK COHOSH ; ESTROGEN-RECEPTOR-BETA ; GROWTH-INHIBITORY ACTIVITY ; HORMONE-RELATED SUPPLEMENTS ; MDA-MB-453 CELLS ; MENOPAUSAL SYMPTOMS
    Abstract: Background:The use of herbal preparations (HEP) to alleviate climacteric disorders is expected to increase as women seek alternatives to menopausal hormone therapy to avoid the associated breast cancer risk. Data are sparse on the long-term effects of HEP containing phytoestrogens and black cohosh on breast cancer risk. Methods: Within a German case-control study, associations between patterns of HEP use and incident breast cancer were investigated in 10,121 postmenopausal women (3,464 cases, 6,657 controls). Information on HEP use was collected in face-to-face interviews supported by a list of brand names. Multivariate logistic and polytomous regression analyses were done. Findings: Ever use of HEP (9.9%) was inversely associated with invasive breast cancer [odds ratio (OR), 0.74; 95% confidence interval (CI), 0.63-0.87] in a dose-dependent manner (OR, 0.96 per year of use; P = 0.03). Classes of HEP did not differ significantly (P-heterogeneity = 0.81). Risks for invasive ductal (OR, 0.72; 95% CI, 0.60-0.87) and combined lobular/mixed/tubular tumors (OR, 0.76; 95% Cl, 0.58-1.01) were similarly reduced by any HEP use but not for in situ carcinomas (1.34; 95% CI, 0.86-2.09). There were no substantial differences in associations of HEP use by estrogen receptor status (ER+ OR, 0.74; 95% Cl, 0.62-0.89; ER- OR, 0.68, 95% CI, 0.50-0.93) and progesterone receptor status of the tumor. Interpretation: Our findings support the hypothesis that HEP use protects from invasive breast cancer in postmenopausal women. Among conceivable modes of action, those independent of estrogen receptor-mediated pathways seem to be involved (i.e., cytotoxicity apoptosis). (Cancer Epidemiol Biomarkers Prev 2009;18(8):2207-13)
    Type of Publication: Journal article published
    PubMed ID: 19661079
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