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  • 1
    ISSN: 1573-9686
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The rates of storage and release of carbohydrate by the liver are deterined by the plasma concentrations of several bloodborne signals; most important are the concentrations of glucose, and the hormones insulin and glucagon. To understand the complex control relationships of these three signals as they affect the liver, their individual dynamic influences have been determined experimentally, and they have been integrated by means of a computer simulation of the pathways of hepatic glycogen metabolism. The simulation studies have led to specific hypotheses about the biochemical effects of glucose and insulin on the liver. The simulation studies have also led to the conclusion that glucose exerts a rapid moment-to-moment influence on the rate of uptake of glucose by the liver. Insulin, however, by exerting a slower influence on the sensitivity of the liver to glucose, is very effective in “optimizing” the amount of glucogen with the liver stores during food intake. Thus, integrated experimental and simulation studies can lead to a view of a physiological regulating system which does not emerge from either approach used alone.
    Type of Medium: Electronic Resource
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  • 2
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    London : Henry Stewart Talks
    Keywords: Diabetes Mellitus, Type 2 ; Hormones ; Metabolic Syndrome X
    Description / Table of Contents: Contents: Metabolic syndrome and type 2 diabetes -- Risk and effect of obesity -- "Metabolic syndrome" -- Pathogenesis of the metabolic syndrome -- Visceral and subcutaneous adiposity in the fat-fed dog model -- "Overflow" hypothesis -- Control diet and high fat diet -- Visceral adiposity -- Hepatic and peripheral insulin resistance -- Distribution of insulin with obesity -- Transendothelial insulin transport (TET) -- Hyperinsulinemia -- Insulin resistance
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 streaming video file (41 min.) : digital, mono., SWF file, sd., col.
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