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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCWI25-1370 /20131023/
    Publication Date: 2013-10-24
    Keywords: zementfreie HTEP ; Hydroxylapatitbeschichtung ; Osteointgration ; radiolucent lines ; SL-PLUS MIA HA -Schaft ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die gestörte Verhornung äußert sich in unterschiedlichen Bildern im Mikroradiogramm (=Röntgenbild von Gewebsschnitten). Die Hornschicht bei Ichthyosis vulgaris zeigt eine gleiche oder bessere Strahlendurchlässigkeit als bei normaler Haut und auch erst recht als das Stratum corneum bei Psoriasis. Die Hornkegel bei der dyskeratosis follicularis Darier und die Hornschicht bei der bullösen Form der kongenitalen ichthyosiformen Erythrodermie sind dagegen wesentlich geringer strahlendurchlässig als normale Haut, bei der bullösen ichthyosiformen Erythrodermie sogar noch geringer als bei der Psoriasis. bei der Dyskeratosis follicularis vegetans ist die Strahlendurchlässigkeit der Corps ronds und Grains meist entsprechend der epidermalen Schicht, in der sie liegen. Die geringe Strahlendurchlässigkeit der Hornstacheln entspricht etwa der psoriasiformen Parakeratose, mit der die Hornstacheln histologisch und histochemisch Ähnlichkeit haben. Entsprechend der Auflösung des Gewebes findet man bei der Alopecia mucinosa in den Schleimzonen eine völlige Strahlendurchlässigkeit. Die umgebenden Infiltrate der Reticulosarkomatose zerstören das Kollagen aber mehr als nach der Ausdehnung der Infiltrate zu erwarten.
    Notes: Summary Pathological changes of the horny layer affect the permeability for x-rays. In ichthyosis vulgaris the horny layer is often more permeable than normal skin and considerably more permeable than in psoriasis. On the other hand, the horny plugs of dyskeratosis follicularis Darier and the horny layer of bullous congenital ichthyosiform erythroderma are much less permeable than normal skin, in the latter the permeability is even less than in psoriasis. In dyskeratosis follicularis Darier the permeability of corps ronds and grains depends on the epidermal layer in which they are situated. The low degree of permeability in the horny plugs of Darier's disease is rather like that of psoriasiforme parakeratosis, to which the horny plugs are histologically and histochemically similar. In alopecia mucinosa the degeneration of the tissue in the mucous areas leads to complete permeability for x-rays. The encompassing infiltration of lymphoblastoma causes more destruction in the collagen than expected, considering the degree of infiltration.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Röntgenbilder von Gewebsschnitten der in der Überschrift genannten Hauterkrankungen mit benignem und malignem Verlauf wurden verglichen. Lupus erythematodes und Lichen ruber planus zeichnen sich durch die vollständige Zerstörung der wenig strahlendurchlässigen kollagenen Bindegewebsbündel aus. Auch bei Urticaria pigmentosa und Mastzellenretikulose zerstören die Infiltrate die Kollagenfaserbündel, eine Neubildung von Bindegewebe ist nicht erkennbar. Die Zerstörung des Bindegewebes geht bei den malignen Wucherungen von Bindegewebszellen meist über diejenige hinaus, die man nach dem H.-E.-Schnitt erwarten würde, und steigert sich mit zunehmender Entartung. Doch haben auch benigne Wucherungen, wie die Lymphadenosis cutis benigna, eine so ausgedehnte Zerstörung des Kollagens zur Folge, daß sich dieser Befund nicht differentialdiagnostisch verwerten läßt. Bemerkenswert ist die im Verhältnis zur Ausdehnung der Infiltrate unerwartet große Zerstörung reifer Kollagenfaserbündel bei der Akrodermatitis atrophicans Herxheimer.
    Notes: Summary Microradiograms (x-rays of tissue sections) were studied in order to compare the effects of different benign and malignant skin diseases on collagen. In lupus erythematodes and lichen planus the collagen was completely destroyed in the areas involved. In urticaria pigmentosa and mastcellreticulosis, collagen was destroyed by mast cell infiltrates, and there was no evidence of any new formation of collagen. In lymphoblastoma the collagen was more severely damaged than one would have expected from the degree of infiltration, however, these findings are of no help in differential diagnosis, as benign infiltrates also destroy the collagen. In relation to the extent of infiltration a surprising degree of destruction in the connective tissue is caused by acrodermatitis atrophicans Herxheimer.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Keywords Retina, vascular endothelial growth factor, permeability, angiotensin converting enzyme.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Angiotensin converting enzyme (ACE) inhibition has been recently suggested to have retinoprotective actions in diabetic patients but the mechanism of this effect is not known. In vitro, angiotensin II stimulates expression of vascular endothelial growth factor (VEGF), a permeability-inducing and endothelial cell specific angiogenic factor which has been implicated in the pathogenesis of diabetic retinopathy in humans and in experimental animals. We sought to determine the effects of ACE inhibition on retinal VEGF expression and permeability in experimental diabetic retinopathy.¶Methods. Streptozotocin-induced diabetic rats and control animals were assigned at random to receive ACE inhibitor treatment or vehicle. At 24 weeks the retinal VEGF protein gene expression was assessed by northern blot analysis and in situ hybridisation. Retinal permeability to albumin was measured using a double isotope technique.¶Results. Experimental diabetes was associated with cell specific two to fourfold increase in retinal VEGF protein gene expression (p 〈 0.01) and a 2-fold increase in retinal vascular permeability to albumin (p 〈 0.01). The localization of VEGF expression in the retina was not altered in animals with experimental diabetes. Angiotensin converting enzyme inhibitor treatment of diabetic rats reduced diabetes-associated changes in VEGF gene expression and vascular permeability.¶Conclusion/interpretation. These findings implicate the renin-angiotensin system in the VEGF overexpression and hyperpermeability which accompany diabetic retinopathy and provide a potential mechanism for the beneficial effects of ACE inhibition in diabetic retinal disease. [Diabetologia (2000) 43: 1360–1367]
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  • 5
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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