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  • 1
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    Steinkopff, Springer
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  68. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); 20180525-20180526; Braunschweig; DOC18vnda30 /20180605/
    Publication Date: 2018-06-06
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    Keywords: tumor ; AGENTS ; INHIBITION ; DISEASE ; RISK ; PROTEIN ; PROTEINS ; DRUG ; MESSENGER-RNA EXPRESSION ; RISK-FACTORS ; mechanisms ; treatment ; antibodies ; risk factors ; NON-HODGKINS-LYMPHOMA ; 4 SUBSTRATE-ANALOGS ; A-CHAIN IMMUNOTOXIN ; antitumor agents ; CELLS IN-VITRO ; Chinese herbal medicines ; CYTOKINE-STIMULATING ACTIVITIES ; high molecular natural compounds ; LYCIUM-BARBARUM L ; MOUSE PERITONEAL- MACROPHAGES ; MULTIPLE PHARMACOLOGICAL PROPERTIES ; RIBOSOME-INACTIVATING PROTEIN
    Abstract: High molecular compound from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi containing such polysaccharides are usually edible mushrooms or tonics in Traditional Chinese Medicine. Parts from high plants such as Radix Astragali and Fructus Lycii containing polysaccharides are mainly used as tonic in Traditional Chinese Medicine. Ribosome-inactivating proteins are a group of proteins exerting cytotoxic activities via inhibition of protein synthesis. Some of the ribosome- inactivating proteins have been used as the cytotoxic part in conjugates with monoclonal antibodies as tumor-targeting drugs. The cytotoxic and antineoplastic mechanisms of the high molecular compounds are rather different from those of the low molecular compounds described in part I
    Type of Publication: Journal article published
    PubMed ID: 12677520
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  • 6
    Keywords: RECEPTOR ; DAMAGE ; Bcl-2 ; AGENT ; INDIVIDUAL CELLS ; DISTINCT CASPASE CASCADES
    Abstract: To study molecular aspects of cytotoxicity of the anticancer drug beta-D-glucose-ifosfamide mustard we investigated the potential of the agent to induce apoptosis and DNA breakage. Since beta-D-glucose-ifosfamide mustard generates DNA interstrand crosslinks, we used as an in vitro model system a pair of isogenic Chinese hamster V79 cells differing in their sensitivity to crosslinking agents. CL-V5B cells are dramatically more sensitive (30-fold based on D(10) values) to the cytotoxic effects of beta-D-glucose-ifosfamide mustard as compared to parental V79B cells. After 48 h of pulse-treatment with the agent, sensitive cells but not the resistant parental line undergo apoptosis and necrosis, with apoptosis being the predominant form of cell death (70 and 20% of apoptosis and necrosis, respectively). Apoptosis increased as a function of dose and was accompanied by induction of DNA double-strand breaks in the hypersensitive cells. Furthermore, a strong decline in the level of Bcl-2 protein and activation of caspases-3, -8 and -9 were observed. The resistant parental cells were refractory to all these parameters. Bcl-2 decline in the sensitive cells preceded apoptosis, and transfection-mediated overexpression of Bcl-2 protected at least in part from apoptosis. From the data we hypothesize that non-repaired crosslinks induced by beta-D-glucose-ifosfamide mustard are transformed into double-strand breaks which trigger apoptosis via a Bcl-2 dependent pathway.
    Type of Publication: Journal article published
    PubMed ID: 11857024
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  • 7
    Abstract: Different processing of the leaves of the tea plant Camellia sinensis yields green or black tea, the subject of numerous investigations on the preventive effects on chronic degenerative diseases. The tea polyphenols, in particular (-)-epigallocatechin gallate (EGCG) were found to account for most of the protective effects. Since the concentration of EGCG is 5 times higher in green than in black tea, it is assumed that green tea possesses a greater preventive potential. Protection against cancer and cardiovascular diseases are the most important biomedical effects. In experimental models the preventive activity of tea is well documented for tumors at many organ sites. In humans, tea was reported to be protective against tumors of the lung, the gastrointestinal tract and the liver. Tea polyphenols, especially EGCG, were shown to exert cancer-protective activity by the following mechanisms: they inhibit the metabolic activation of carcinogens and induce at the same time detoxifying enzymes. They inhibit signaling pathways controlling cell proliferation and tumor growth such as protein kinase C and the release of tumor necrose factor-alpha from cells. Tea polyphenols reactivate processes which are impaired in tumor cells, such as the programmed cell death and the tumorsuppressor gene p53. Finally, tea polyphenols can also block angiogenesis leading to a starvation of the tumor. By inactivation of proteolytic enzymes they inhibit the development of metastases. This short review summarizes relevant recent findings on the protective effects of green tea constituents.
    Type of Publication: Journal article published
    PubMed ID: 11998565
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  • 8
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    German Medical Science; Düsseldorf, Köln
    In:  GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; VOL: 1; DOC050 /20051206/
    Publication Date: 2005-12-07
    Description: Einleitung : Clarion-Implantate bei Kindern wurden überwiegend mit der Sprachverarbeitungs-strategie SAS (Simultanious Analogue Stimulation) programmiert. Nunmehr steht als Alternative die HiRes (High Resolution)-Strategie (sehr hohe Stimulationsrate) zur Verfügung.Design : Prospektive klinische Anwendungsbeobachtung unter Einbeziehung einer bestehenden SAS-KontrollgruppeMethode : Ausgesprochen erfolgreiche Versuche mit HiRes bei CI-versorgten Erwachsenen waren die Vorraussetzung für einen Beginn mit HiRes auch bei Kleinstkindern. Die HiRes-Gruppe umfasste 9 Kinder (durchschnittliches Implantationsalter ca. 1,5 Jahre). Die SAS-Kontrollgruppe wies 8 Kinder auf (durchschnittliches Versorgungsalter ca. 2,7 Jahre). Der Verlauf der Hör-Sprachentwicklung wurde mittels adaptierter MAIS- und MUSS-Fragebögen prä- sowie bisher postoperativ nach 3 und 6 Monaten dokumentiert.Ergebnisse : Sowohl MAIS- als auch MUSS-Resultate der HiRes-Gruppe liegen zunächst etwa gleichauf mit der SAS-Gruppe; nach 6 Monaten jedoch zeigt die HiRes-Gruppe deutlich bessere Ergebnisse im MAIS-Fragebogen, aber schlechtere im MUSS. Unbedingt zu berücksichtigen ist, dass das Implantationsalter der HiRes-Gruppe durchschnittlich 1,2 Jahre unter dem der SAS-Gruppe liegt. Resultate deutlich späterer Testzeitpunkte werden besonders zu beachten sein, wenn dem Einfluss des individuellen Testalters weniger Bedeutung zukommt.Zusammenfassung : Die bisher vorliegenden, sehr vielversprechenden Erfahrungen und Resultate erlauben die HiRes-Programmierung als Standardprozedur auch bei Kleinstkindern. Die Programmiersoftware ist sehr stabil und einfach zu bedienen.
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 9
    Keywords: CANCER ; Germany ; human ; RISK ; TIME ; ACTIVATION ; DNA ; RISK-FACTORS ; INDUCTION ; INTERVENTION ; CELL-LINES ; treatment ; SUSCEPTIBILITY ; ASSAY ; risk factors ; (-)-epigallocatechin gallate ; ADP-RIBOSE POLYMERASE ; cancer risk ; COMET ASSAY ; DAMAGE ; EPIGALLOCATECHIN GALLATE ; genotoxicity ; GREEN TEA ; GROWTH-INHIBITION ; LYMPHOCYTES ; poly(ADP-ribose) polymerase ; POLY(ADP-RIBOSYL)ATION ; POLYPHENOLS ; QUERCETIN ; repair mechanisms ; RISK FACTOR ; tea catechins
    Abstract: With regard to a future use of tea polyphenols, in intervention trials with individuals at high cancer risk, the effects of the tea ingredient (-)-epigallocatechin gallate (EGCG) on poly(ADP- ribose) (PAR) levels and on DNA damage were investigated in human lymphocytes. A dose- and time-dependent elevation of both PAR formation as assessed by quantitative immunofluorescence analysis and DNA damage as assessed by the comet assay were observed after treatment with EGCG at 20, 40 and 80 muM for 10- 240 min. Maximum levels of PAR formation and of DNA damage were observed after 10 min at all concentrations tested. Increased PAR levels were still detectable by 240 min in the 40 and 80 muM groups. At the lowest concentration, which is near the physiological peak values found after tea ingestion, PAR formation was not correlated with DNA damage. Here, EGCG led to pronounced PAR levels, whereas the comet assay was almost negative. In contrast, such marked differences in time course and extent of both genotoxicity and PAR formation following EGCG treatment were not detected after gamma-irradiation. Our results suggest that the known chemopreventive effects of EGCG, the main constituent of tea, may be partly attributed to an induction of PAR formation, (C) 2002 Elsevier Science B.V. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 12504756
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  • 10
    Keywords: APOPTOSIS ; CANCER ; tumor ; AGENTS ; Germany ; INHIBITION ; KINASE ; THERAPY ; POPULATION ; RISK ; PROTEIN ; DRUG ; DNA ; RISK-FACTORS ; INDUCTION ; BASE ; mechanisms ; protein kinase ; risk factors ; PROSTATE-CANCER ; chemotherapy ; PROTEIN-KINASES ; PROTEIN-KINASE-C ; pharmacokinetic ; PHARMACOKINETICS ; HUMAN TUMOR-CELLS ; antitumor agents ; Chinese herbal medicines ; BENZOPHENANTHRIDINE ALKALOIDS ; CANCER CELL-LINES ; CHELIDONIUM-MAJUS ; CITRUS FLAVONOIDS ; DNA TOPOISOMERASE-I ; ISODON DITERPENOIDS ; low molecular natural compounds ; MURINE HEPATOMA-CELLS ; traditional Chinese medicine
    Abstract: A series of low molecular compounds from Chinese herbal medicines which have proved to be, in some cases, highly effective especially in tumor therapy, is listed here (part II will deal with high molecular compounds, to be published in the next issue). In contrast to synthetic agents used in cancer chemotherapy, these natural compounds have relatively low toxicities. Many of the clinical studies referred to in this paper have been carried out on Asians. Because genetic factors influence enzyme levels, sometimes leading to striking differences in metabolism and pharmacokinetics of drugs, results obtained in clinical studies carried out in China are not 100% transferable to the European population. The mechanisms of action of these compounds are manifold, consisting of reactions with DNA bases, intercalation in DNA, inhibition of topoisomerases, inhibition of protein kinases, induction of apoptosis etc. Some of the compounds have interesting structural features, that may be used as lead structures for the development of further antitumor agents
    Type of Publication: Journal article published
    PubMed ID: 12677520
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