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  • 1
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Urological diseases ; Urological operations ; Pregnancy ; Urologische Erkrankungen ; Urologische Operationen ; Schwangerschaft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Urologische Erkrankungen wie die Urolithiasis, Anomalien der Niere und ableitender Harnwege, sowie Pyelonephritis und selten Tumoren der Niere und der Harnblase können Ursache operativer Eingriffe während der Schwangerschaft sein. Die häufigste von den Harnwegen ausgehende Komplikation in der Schwangerschaft ist die Entzündung. Diagnose und Therapie urologischer Erkrankungen in der Schwangerschaft hat im besonderen Maße auf Folgeerscheinungen dieser Untersuchungstechniken Rücksichten zu nehmen. Die besonderen Probleme in der Behandlung maligner Tumoren der Niere und Harnblase, der Schwangerschaft nach Nierentransplantation und der Schwangerschaft bei Harnleiterdarmimplantationen werden behandelt.
    Notes: Summary Urologie diseases such as urolithiasis, anomalies of the kidney and efferent urinary tracts as well as pyelonephritis and, more rarely, tumors of kidney and urinary bladder can be the cause of surgical operations during pregnancy. Inflammation is the most frequent complication starting from the urinary tract during pregnancy. Diagnosis and therapy have to take into consideration consequences arising from these examination techniques. The special problems of treatment of malign tumors of kidney and urinary bladder, and pregnancy after transplantation and ureterobowel implantation will be reported.
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  • 4
    ISSN: 1435-2451
    Keywords: Computed tomography ; Tumor diagnosis ; Urology ; Urologie ; Computertomographie ; Tumor-Diagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sonographie und Computertomographie sind exakte Diagnostikmöglichkeiten in der Urologie. Erfaßt werden Veränderungen des Retroperitonealraumes, vor allem an den Nieren, Nebennieren, Lymphknoten. Das CT ergibt beim Nierentumor die Organkontur, Dichte des Tumors und Verdrängung des Hohlraumsystems. Aussagesicherheit 85%–95%. Die Stadienbestimmung bei Patienten mit Hodentumoren ist eine weitere Indikation des CT. Für die Primärdiagnostik des Harnblasen- und Prostatacarcinoms ist das CT nicht von Wert, jedoch können hier Organgrenzen überschreitende Prozesse erfaßt werden. Das CT hat Bedeutung für die Verlaufskontrolle und Strahlentherapieplanung dieser Tumoren.
    Notes: Summary Sonography and Computed tomography are exact methods of diagnosis in urology. They reproduce changes in the retroperitoneal space, especially of the kidney, adrenal gland, and lymph nodes. CT shows contours of the organ, density of tumor, and displacement of hollow system. Positive evidence is 85%-95%. Tumor staging in patients with testicular tumors is a further indication for CT. For primary diagnosis of a tumor of the urinary bladder and prostate CT is of no value, but processes passing across the organ boundries can be seen. CT is important for the control of the process as well as for planning the X-ray therapy of this tumor.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Infection 1 (1973), S. 208-213 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Neither studies with kidney slices and homogenized renal tissue nor autoradiographic studies have been able to show the real concentration levels of the renal interstitium. The determination of renal lymph concentrations is believed to be the best method today as it allows the separation of the urine. In order to avoid misinterpretations, studies should be performed under constant plasma levels using in addition a reference substance, e.g. iothalamate. Antibiotics with high renal clearances, e.g. carbenicillin, cephatrile, cephaloridine and ampicillin, show a significantly lower concentration in lymph than in arterial plasma. Studies have shown that in hydronephrotic kidneys, with and without infection, the concentration levels in the two fluid compartments become almost identical.
    Notes: Zusammenfassung Sowohl Untersuchungen mit Nierengewebshomogenat bzw. -scheiben als auch autoradiographische Untersuchungen sind bisher nicht in der Lage, die Antibiotikakonzentrationen im Interstitium aufzuzeigen. Die Nierenlymphe ist dazu am besten geeignet, da hierbei die Abtrennung des Urinanteils der Harnwege möglich ist. Die Untersuchungen sollten unter konstanten Plasmaspiegeln und unter Verwendung einer Standardsubstanz, z. B. Jothalamat, durchgeführt werden. Antibiotika mit hoher renaler Clearance, wie z. B. Carbenicillin, Cephacetril, Cephaloridin und Ampicillin haben normalerweise eine deutlich niedrigere Nierenlymph-als arterielle Plasmakonzentration. Bei Harnstauungsnieren mit und ohne Infekt dürften sich die Konzentrationsverhältnisse in beiden Verteilungsräumen annähern.
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  • 6
    ISSN: 0009-8981
    Keywords: 6-Sulfatoxymelatonin ; Melatonin ; Prostate cancer
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-0879
    Keywords: Vitamin D ; 1,25-Dihydroxycholecalciferol Nephrolithiasis ; Calcium antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Investigations were carried out as to whether cytoprotective agents such as calcium antagonists can influence vitamin D induced nephrolithiasis. Increased vitamin D levels are found in 10–30% of all calcium oxalate stone formers. Male rats were assigned to one of the following groups: (1) 1,25-dihydroxycholecalciferol (DHCC) (n=8), (2) 1,25-DHCC+calcium antagonist Goe 6070 (a new 1,4-dihydronaphthyridine, Goedecke, Berlin) (n=8), or (3) control (n=8). 1,25-DHCC was administered for 6 days (120 pmol/24 h s.c.), Goe 6070 (1 mg/kg/24 h) by gavage. Clearance studies were performed on day 6. Kidneys were taken for histological examination and determination of calcium tissue content. 1,25-DHCC induced substantial concrement formation, which could be significantly limited by Geo 6070. The calcium tissue content was also reduced (0.17 vs. 0.04 mg/100 mg dry weight). 1,25-DHCC induced a dramatic fall in the glomerular filtration rate (GFR) (3.84 ml/min per kilogram). This reduction could be almost completely inhibited by the concomitant application of Goe 6070 (9.4 ml/min per kilogram; control 10.7 ml/min per kilogram). Goe 6070 did not influence the calcium handling. The results demonstrate a protective effect of Goe 6070 on vitamin D induced nephrolithias. The histological pattern (intracellular and membrane-bound concretions) and the fact that biochemical parameters were not influenced significantly by Goe 6070 indicate that cellular processes are important for 1,25-DHCC-induced nephrolithiasis.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 7 (1979), S. 139-142 
    ISSN: 1434-0879
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-0879
    Keywords: ESWL ; Shock waves ; MDCK cells ; LDH ; GOT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Shock wave lithotripsy (ESWL) has become an almost non-invasive standard treatment modality for urolithiasis. Several investigations, however, demonstrated that ESWL is not completely free of side effects. Among others alteration of renal tubular function has been reported. To study the effect of shock waves on tubular cells directly an in-vitro model with cultured Madin Darby Canine Kidney (MDCK) cells was established. Suspensions of MDCK cells (7 groups of 6 containers each) were exposed to 0, 16, 32, 64, 128, 256 shock waves (Dornier HM4, 18 kV). Before and 0, 1, 3, 6, 9, 12, 24 h after ESWL the following parameters were measured in the nutrient medium: lactate dehydroxygenase (LDH), glutamate oxalacetate transaminase (GOT), electrolytes. LDH and GOT increased depending on the number of shock waves indicating a membrane damage of MDCK cells. The MDCK model seems suitable for further studies on the effect of shock waves on renal tubular cells.
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  • 10
    ISSN: 1434-0879
    Keywords: Tumor necrosis factor ; Renal-cell carcinoma ; Uromodulin ; Tamm-Horsfall protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The use of tumor necrosis factor (TNF) in immunotherapy of tumor diseases has attracted increasing interest. Since the direct antitumor effect of the TNF is mediated by receptor-bound TNF, we immunohistologically stained both benign and malignant tissue from 35 tumor-bearing human kidneys for TNF. Using a polyclonal anti-TNF-antiserum, paraffin sections were tested in the presence and absence of in vitro preincubation with TNF. Futhermore, all specimens were stained immunohistologically for Tamm-Horsfall protein (THP) because this renospecific glycoprotein can bind TNF in a lectin-like manner. In the absence of TNF preincubation, malignant tissue was TNF-positive in 34 specimens, as was benign tissue from the same tumor-bearing kidneys in 35 cases. In several specimens the staining was so intense that preincubation with TNF did not enhance the reaction. Whereas TNF staining in tumor tissue was relatively homogenous, that in benign tissue was intensive in distal tubuli, moderate in proximal tubuli, and negative in glomeruli. THP staining was negative in malignant kidney tissue but positive in the distal tubuli of benign tissue, i. e., in the regions in which TNF staining was most intense. These results indicate that TNF binds not only to membrane, most likely in a receptor-mediated manner, but also to THP both in vivo and in vitro. In vivo binding of TNF to THP was confirmed in animal experiments in which pigs were given injections of TNF. Immunohistological staining of the animals' kidneys revealed positive reactions for both TNF and THP at the distal tubuli, indicating TNF binding to THP after in vivo TNF administration. The presence of TNF in human kidney tumors implies that renal-cell carcinoma cells in situ are resistant to the direct cytotoxic effect of TNF. This resistance should be taken into account when TNF is considered for use as a possible immunotherapeutic agent in renal-cell carcinoma.
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