Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Unknown
    Berlin : Springer
    Call number: QZ241.6:10
    Keywords: Neoplasms / radionuclide imaging ; Tomography, Emission-Computed / methods
    Pages: xiv, 350 p. : 157 fig. (some col.), 60 tab.
    ISBN: 354043125X
    Signatur Availability
    QZ241.6:10 available
    BibTip Others were also interested in ...
  • 2
    Call number: QZ241.6:11
    Keywords: Neoplasms / radionuclide imaging ; Tomography, Emission-Computed / methods
    Pages: xii, 203 p. : ill.
    ISBN: 3540650776
    Signatur Availability
    QZ241.6:11 available
    BibTip Others were also interested in ...
  • 3
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Positronen-Emissions-Tomographie (PET) ; Neurologie ; Neurochirurgie ; Psychiatrie ; Key words Positron emission tomography ; Neurology ; Neurosurgery ; Psychiatry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To date, positron emission tomography (PET) is the most powerful method for the in-vivo investigation of human brain metabolism. Besides extensive application of this technology in the neurosciences, PET is also being increasingly used as a clinical tool. However, despite its acceptance in clinical practice, a major obstacle is its high costs. The present article reviews the literature on the clinical use of PET in neurology, neurosurgery, and psychiatry in order to substantiate the clinical indications for PET in these specialties as established by an interdisciplinary conference.
    Notes: Zusammenfassung Die Positronen-Emissions-Tomographie (PET) ist das derzeit leistungsfähigste Verfahren zur In-vivo-Untersuchung des zerebralen Stoffwechsels. Neben einem breitgefächerten Einsatz von PET in der neuromedizinischen Forschung findet die PET zunehmend auch Eingang in die klinische Diagnostik. Dieser Entwicklung entgegen stehen die relativ hohen Kosten, die mit diesem Verfahren verbunden sind. Die vorliegende Arbeit begründet die, in einer interdisziplinären Konferenz erarbeiteten Konsensusindikationen für den klinischen Einsatz der PET in der Neurologie, Neurochirurgie und Psychiatrie durch Aufarbeitung der einschlägigen Literatur.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Das hier Gesagte trifft auch auf die onkologische Nuklearmedizin zu. Wenn auch die Immunszintigraphie nicht die Erwartungen erfüllt hat, so lassen neuere Entwicklungen doch erhoffen, daß die Nuklearmedizin für die onkologische Diagnostik und Therapie wichtige Ergebnisse liefern kann. Fortschritte sind neben der weiteren Verbreitung aufwendiger Untersu-chungsgeräte durch neue Radiopharmaka zu erwarten. Hierbei erlauben dedizierte 3-Kopf-Kameras bzw. Ringkristallsysteme eine bessere Ortsauflösung und eine verbesserte Ausnutzung der emittierten Gammaenergie. Auf ,,konventionellem`` Gebiet werden sich Tc-99m markierte, niedermolekulare Peptide durchsetzen. Die Positronenemissionstomographie (PET) wird in Zukunft verstärkt zum Einsatz kommen. Logistische Schwierigkeiten – bedingt durch die kurze Halbwertszeit von F-18 Fluordeoxyglucose (FDG) – lassen sich durch flächendeckende Produktion am Zyklotron reduzieren. Im folgenden werden der gegenwärtige Stand und die zukünftige Entwicklung der einzelnen Verfahren dargelegt.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1433-8580
    Keywords: Rat renal allograft ; GvHR ; allorosette ; blocking factor ; Rattennierentransplantation ; GvHR ; Allorosettenformation ; blockierender Serumfaktor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 53 LBNF1-Nieren wurden auf L-Ratten transplantiert: 24 unbehandelte Empfänger überlebten durchschnittlich 16,1 ± 1,7 Tage. 14 Empfänger bekamen je 4 ml Alloantiserum (ADS, Gruppe 2), die restlichen 15 je 4 ml ALS (Gruppe 3). Davon überlebten 9 bzw. 10 Empfänger mehr als 4 Monate. Mit Milzzellen dieser permanent überlebenden 19 Ratten wurde eine GvHR durchgeführt. Grad und Index der GvHR ergaben eine normale, zellgebundene Immunantwort der Empfänger. Nach der Splenektomie erhielten sie erstmalig, 18 Tage später zum zweiten Mal Haut von LBNF1, 18 Tage danach Haut von LBufF1 transplantiert. Das erste Transplantat überlebte in der ADS-Gruppe 13,1 ± 1,9 Tage, in der ALS-Gruppe 12,2 ± 1,2 Tage. Das zweite wurde bei Gruppe 2 ebenfalls verzögert, bei Gruppe 3 fast gleich wie bei unbehandelten L-Ratten, das unspezifische Transplantat in beiden Gruppen regelrecht abgestoßen. Lymphozytotoxin und Hämagglutinin wurden vor und nach der Hauttransplantation bis zum 53. Tag nicht nachgewiesen. Die Seren beider Gruppen inhibierten die Allorosettenformation auf 46,0 ± 4,4% (ADS-Gruppen) bzw. 37,7 ± 9,2% (ALS-Gruppe), somit war ein blockierender FAktor im Serum der Empfänger vorhanden. Höchstwahrscheinlich hatten sich also bei diesen Empfängern nach der ALS-Therapie blockierende Antikörper gebildet, woraus sich ein Enhancement der Nierentransplantate entwickelte.
    Notes: Summary 53 LBNF1 kidneys were grafted into L-rats. 24 untreated recipients served as control and survived 16.1 ± 1.7 days. 14 recipients were treated with 4 ml alloantiserum (ADS) each, and the other 15 animals with 4 ml ALS each. 9 and 10 of these 14 and 15 animals survived for more than 4 months. We performed GvH-reaction with spleen cells of these 19 animals. It showed normal cellular immune response. After splenectomy first donor specific skin was transplanted, 18 days later second skin of same origin (LBNF1) and 18 days after third party skin (LBufF1). The first grafts survived 13.1 ± 1.9 days in the recipients of ADS treatment and 12.2 ± 1.2 days in the recipients of ALS. Second skin grafts were rejected delayed in the former recipients as the first grafts, in the later more accelerated than the first grafts. The third grafts survived as the controls. Before and after skin grafting we could not detect lymphocytotoxin and hemagglutinin. The sera of animals with ADS therapy inhibited the spontaneous allorosette formation to 46.0 ± 4.4% and of ALS therapy 37.7 ± 9.2%. Our results suggest that after ALS treatment blocking antibodies were produced in the recipients and they cause the enhancement of kidney allograft.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-0711
    Keywords: Immunoscintigraphy ; Cancer of the ovary ; Tumor marker CA 125 ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Radioimmundetection (RID) using anti-CA 125 antibodies proved to be a valuable tool in the follow-up of metastasizing ovarian cancer. Sensitivity, specificity, and accuracy were high. RID had no clinical side effects. But some patients formed antibodies which interfered a) with the evaluation of the scintigram and b) with further measurement of CA 125 levels. We found 2 cm diameter metastases that were not detected by computed tomography. However, the heterogeneity of tumor metastases limits the sensitivity of this method. CA 125 serum levels, immunohistochemistry, and immunoscintigraphy did not always correlate. Monitoring serum levels of CA 125 was most valuable in clinical management of tumor spread and in the optimal use of RID.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-0711
    Keywords: Photodynamic therapy ; Dye laser ; Phthalocyanine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Photodynamic therapy (PDT) with laser radiation opens a new field in the treatment of malignancies. We evaluated the phototoxic effects of five different substances for photodynamic therapy in concentrations showing no systemic toxicity. We used gynecologic tumor cells and evaluated the photodynamic effects for cell growth in a colony-forming assay. For Indigocarmin we found a reduction in the colony-forming assay compared to the control group from 87% to 66% after irradiation at 50 µmol/l and 608 nm wavelength. “IR132” showed a reduction in the colony-forming assay from 73% to 72% 50 µmol/l (590 nm). For the incubation of the HeLa cells with 50 µmol/l of “Sulfo-Phthalocyanin” we found a reduction of the colony-forming potential from 81% to 67% (595 nm). The most strikingly differences were found for the incubation and irradiation of Methylene Blue, showing a reduction from 77% to 16% caused by a toxic effect of the substance itself (5 µmol/l, 660 nm) and “Sulfo-Aluminium-Phthalocyanin” stained cells, which shows a reduction from 86% to 17% (50 µmol/l, 675 nm). We see the possibility of a photoactivation and cell devitalisation by “Sulfo-Aluminium-Phthalocyanin” and laser radiation. A future clinical trial would seem justified.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Dosisüberprüfung der Antikörper-Farbstoff-Menge zur photodynamischen Therapie wurde für Biodistribution und Farbstoffkonzentration am Tumor mittels einer Doppelmarkierung mit131I und Phthalocyanin durchgeführt. Der Farbstoff-Antikörper-Komplex reicherte sich im Tumor mit dem Faktor 8 gegenüber umliegenden Muskelgewebe an. Durch Vergleich mit Zellkultur-Experimenten errechnete sich eine notwendige Antikörper-Applikation von 0,5 mg/kg Körpergewebe.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-five patients with 60 suspected infections of bones or joints were studied with 99mTc-hexamethyl-propyleneaminooxine-(HMPAO-) labelled leucocytes and 99mTc-labelled antigranulocyte antibodies, in part supplemented with 99mTc-labelled nanocolloid. The findings using the different procedures were in good agreement. Apart from in vertebral lesions, a negative scan — even if the radionuclide bone scan is positive — excludes an infection with high probability (sensitivity 94%). The low specifity (57%) is due to positive imaging of various non-infected lesions. Spondylitis usually shows as nonspecific cold lesions. A subtraction technique with computer assisted analysis of HMPAO and nanocolloid scans provides a more precise diagnosis of this condition.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1433-8491
    Keywords: Key words HMPAO-SPECT ; Alzheimer’s disease ; Hypoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The primary objective of this study was to test hypotheses about the relationship between HMPAO-SPECT findings and probable Alzheimer’s disease (DAT) in a relatively large sample of patients diagnosed according to DSM-III-R. SPECT patterns of 20 controls and 116 DAT patients were investigated. Left and right frontal, temporal, parietal and occipital regions of the brain were rated as showing a hypoperfusion or not. A wide variety of patterns were found and these are described in detail below. In DAT patients, temporal and/or parietal regions were affected significantly more often (88%, p 〉 0.001) than frontal and/or occipital regions (70%). A bilateral temporoparietal pattern, which has been repeatedly reported as typical for DAT, was observed in 48% of DAT patients, but also in 25% of controls, and did not differentiate significantly between these two groups (p 〉 0.05). Conversely, more than three regions with hypoperfusion were observed significantly more often in DAT patients (48%, p 〈 0.01) than in controls (10%). In DAT patients, the number of regions with hypoperfusion correlated significantly with the score of the Mini Mental State Examination (MMSE, r = 0.33, p 〈 0.001). The frequency of at least one hypoperfusion was approximately equal in left and right hemispheres (77% vs. 73%, p = 0.2). The hypothesis that cognitive decline in DAT starts in the temporal regions was tested in 14 SPECT patterns showing only one region with hypoperfusion. In 12 of these patterns, a temporal region was in fact affected (p 〈 0.001). Whereas hypoperfusion in frontal areas was not accompanied by a significantly lower MMSE than when only temporoparietal regions were affected, MMSE scores were significantly lower when occipital regions were affected in addition to temporoparietal regions (p 〈 0.05). The clinical use of SPECT findings was tested in discriminating analyses with the MMSE and a delayed recall test as additional predictors of DAT. Whereas the MMSE and the delayed recall test differentiated significantly between DAT patients and controls, SPECT findings yielded no further differentiation. In conclusion, the theoretical and clinical implications of SPECT findings and their relationships to other physiological and psychological variables deserve further investigation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...