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  • 1
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    Seminars in Immunopathology 38 (1), 97-112 
    Abstract: Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms revealed that the clinical expression of LE is predisposed by susceptibility genes and that various environmental factors are responsible for an abnormal immune response. Several studies demonstrated that ultraviolet (UV) light is one of the major factors in the pathogenesis of the disease. Standardized photoprovocation in patients with LE has been shown to be a safe and efficient model for evaluating the underlying pathomechanisms which lead to the production of autoantibodies and immune complexes. In particular, interferons were defined as important players in the early activation of the immune system and were observed to play a specific role in the immunological interface between the innate and the adaptive immune system. Abnormalities or disturbances in the different processes of cell death, such as apoptosis or necrosis, have also been recognized as crucial in the pathogenesis of LE. Although each process is different and characterized by unique features, the processes are interrelated and result in a complex disease.
    Type of Publication: Journal article published
    PubMed ID: 26637330
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  • 2
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    Lupus 17 (5), 389-393 
    Keywords: APOPTOSIS ; CELLS ; EXPRESSION ; IRRADIATION ; tumor ; CELL ; Germany ; MODEL ; DISEASE ; EXPOSURE ; SITE ; PROTEIN ; ACCUMULATION ; RELEASE ; PATIENT ; INDUCTION ; KERATINOCYTES ; SKIN ; T cell ; T cells ; T-CELL ; T-CELLS ; TOLERANCE ; ALPHA ; cytokines ; NUMBER ; CLEARANCE ; TNF-ALPHA ; inflammation ; SUNLIGHT ; AUTOANTIGEN ; RE ; LIGHT ; REGULATORY T-CELLS ; APOPTOTIC CELLS ; ENGLAND ; ULTRAVIOLET-IRRADIATION ; INFLAMMATORY SKIN-LESIONS ; SUNSCREENS
    Abstract: Although for decades sunlight was suspected to be involved in the development of cutaneous lupus erythematosus (CLE), only in recent years research on the effects of ultraviolet irradiation on the skin of patients with CLE has resulted in a more comprehensive model for the pathogenesis of the disease. In this model, exposure to UV light induces apoptosis of keratinocytes and the release of pro-inflammatory cytokines. In susceptible patients, the presence or even accumulation of apoptotic cells results in the induction of characteristic inflammatory skin lesions, which might be due to a delayed and pro-inflammatory clearance of these apoptotic cells. Many other factors, in part genetically determined, are involved in CLE resulting in a very heterogeneous clinical manifestation. Among these factors, presence of autoantibodies, a decreased number of regulatory T cells at the site of inflammation and increased expression of pro-inflammatory cytokines like TNF alpha and IFN-inducible protein myxovirus protein A have been shown to play a role in the pathogenesis of CLE
    Type of Publication: Journal article published
    PubMed ID: 18490414
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  • 3
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presence ofHelicobacter pylori in the oral cavity (6 sites), oesophagus, stomach and bowel of 20 dyspeptic patients was investigated. Samples were cultured on three selective media and analyzed by 16S rDNA polymerase chain reaction (PCR) and southern hybridization.Helicobacter pylori DNA was detected by PCR from oral-cavity samples of three (20 %) and from faeces samples of only one (7 %) of the patients whose stomach biopsies were positive forHelicobacter pylori. When culture was used, the microorganism's rate of recovery from the oral cavity and faeces was 13 % and 7%, respectively. One patient had aHelicobacter pylori-like organism in samples collected from the tongue and palate. Both strains were urease, catalase and oxidase positive and grew microaerophilically but were negative on PCR analysis. This demonstrates the possibility of false identification ofHelicobacter pylori by use of routine enzyme reactions. Interestingly, specimens collected from the cheeks of three patients were positive forHelicobacter pylori by PCR analysis. This is the first instance of detection of this micro-organism in the cheek.
    Type of Medium: Electronic Resource
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