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  • 1
    Keywords: Stem Cells ; Oncology ; Cell Cycle ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Cell Cycle Analysis ; Springer eBooks
    Description / Table of Contents: Multilayered heterogeneity of glioblastoma stem cells: biological and clinical significance -- Heterogeneity of head and neck squamous cell carcinoma stem cells -- Heterogeneity of small cell lung cancer stem cells -- Heterogeneity of hepatic cancer stem cells -- Heterogeneity and plasticity of breast cancer stem cells -- Heterogeneity of melanoma with stem cell properties -- Heterogeneity of colon cancer stem cells -- Urothelial cancer stem cell heterogeneity -- Acute myeloid leukemia stem cell heterogeneity and its clinical relevance -- Contribution of chronic myeloid leukaemia (CML) as a disease model to define and study clonal heterogeneity -- The heterogeneity of osteosarcoma: the role played by cancer stem cells -- Ovarian cancer stem cell heterogeneity -- Index
    Abstract: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians
    Pages: XII, 228 p. 24 illus., 18 illus. in color. : online resource.
    ISBN: 9783030143664
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  • 2
    Keywords: Cell Biology ; Cancer Research ; Oncology   ; Cell Biology ; Cancer Research ; Oncology ; Springer eBooks
    Description / Table of Contents: The intestinal tumour microenvironment -- Gastric Tumor Microenvironment -- Parathyroid tumor microenvironment -- Microenvironment in Cardiac Tumor Development: What Lies Beyond the Event Horizon? -- The roles of bone marrow-resident cells as a microenvironment for bone metastasis -- Adipose tumor microenvironment -- Appendix Tumor Microenvironment -- Spinal cord tumor microenvironment -- Cancer stem cell niche and immune-active tumor microenvironment in testicular germ cell tumors -- Tumor microenvironment in skin carcinogenesis -- Index
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment
    Pages: XII, 147 p. 25 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030362140
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  • 3
    Keywords: Cell Biology ; Cancer Research ; Oncology   ; Cell Biology ; Cancer Research ; Oncology ; Springer eBooks
    Description / Table of Contents: Shaping of the tumor microenvironment by Notch signaling -- Erythropoietin signaling in the microenvironment of tumors and healthy tissues -- Neuropilin – handyman and power broker in the tumor microenvironment -- Translational landscape of mTOR signaling in integrating cues between cancer and tumor microenvironment -- Toll-like receptors signaling in the tumor microenvironment -- Rho-ROCK signaling in normal physiology and as a key player in shaping the tumor microenvironment -- S1P signaling in the tumor microenvironment -- CD200-CD200R pathway in the regulation of tumor immune microenvironment and immunotherapy -- Index
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment
    Pages: XI, 170 p. 38 illus., 35 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030355821
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  • 4
    Keywords: Stem Cells ; Oncology ; Cell Cycle ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Cell Cycle Analysis ; Springer eBooks
    Description / Table of Contents: Stem cells heterogeneity -- Heterogeneity in epiblast stem cells -- Progenitor cell heterogeneity in the adult carotid body germinal niche -- Planarian stem cell heterogeneity -- The cellular origin of Barrett’s esophagus and its stem cells -- Pluripotent stem cell heterogeneity -- Sarcoma stem cell heterogeneity -- Heterogeinity in adipose derived stem cells -- Unveiling stem cell heterogeneity towards the development of salivary gland regenerative strategies -- Heterogeneity of human mesenchymal stromal/stem cells -- Mitochondrial heterogeneity in stem cells -- The heterogeneity of renal stem cells, and their interaction with bio- and nano-materials -- Index
    Abstract: This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians
    Pages: XII, 225 p. 45 illus., 38 illus. in color. : online resource.
    ISBN: 9783030110963
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  • 5
    Keywords: Cancer Research ; Biomechanics ; Cancer Research ; Biomechanics ; Springer Nature eBook
    Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment
    Pages: XIII, 208 p. 28 illus., 26 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445188
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  • 6
    Keywords: Cell Biology ; Cancer Research ; Oncology   ; Cell Biology ; Cancer Research ; Oncology ; Springer Nature eBook
    Description / Table of Contents: Cathepsin D in the tumor microenvironment of breast and ovarian cancers -- Galectins in the tumor microenvironment: Focus on galectin-1 -- Iron in the tumor microenvironment -- Oxygen in the tumor microenvironment: mathematical and numerical modeling -- Roles for Phospholipase D1 in the tumor microenvironment -- Leptin in tumor microenvironment -- The immune consequences of lactate in the tumor microenvironment -- Fatty acid mediators in the tumor microenvironment -- Extracellular Vesicles in the tumor microenvironment: various implications in tumor progression -- Index
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more. Taken alongside its companion volumes, these books update us on what we know about the tumor microenvironment as well as future directions. Tumor Microenvironment: Molecular Players – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment
    Pages: XII, 175 p. 31 illus., 20 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430931
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  • 7
    Keywords: Stem Cells ; Oncology ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Pericytes in cutaneous wound healing -- Pericytes in glioblastomas: multifaceted role within tumor microenvironments and potential for therapeutic interventions -- Pericytes in breast cancer -- Pericytes in sarcomas and other mesenchymal tumors -- Pericytes in metastasis -- The role of pericytes in Amyotrophic Lateral Sclerosis -- Pericytes in Alzheimer’s Disease: novel clues to cerebral amyloid angiopathy pathogenesis -- Pericytes in Multiple Sclerosis -- Pericytes in ischemic stroke -- Pericytes in Hereditary Hemorrhagic Telangiectasia -- Pericytes in primary familial brain calcification -- Pericytes in type 2 diabetes -- Pericytes in atherosclerosis -- Pericytes in chronic lung disease -- Pericytes in muscular dystrophies -- Index
    Abstract: This volume explores pericytes' roles under distinct pathological conditions, ranging from tumors, ALS, Alzheimer’s disease, Multiple Sclerosis, stroke, diabetes, atherosclerosis, muscular dystrophies and more. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology – Novel Concepts, Pericyte Biology in Disease presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cell biology and clinicians involved with these specific diseases
    Pages: XII, 355 p. 62 illus., 57 illus. in color. : online resource.
    ISBN: 9783030169084
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  • 8
    Keywords: Cancer Research ; Stem Cells ; Regenerative Medicine ; Tissue Engineering ; Cancer Research ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Springer eBooks
    Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index
    Abstract: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment
    Pages: XI, 160 p. 31 illus., 30 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357276
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  • 9
    Keywords: Cell Biology ; Cancer Research ; Oncology   ; Cell Biology ; Cancer Research ; Oncology ; Springer eBooks
    Description / Table of Contents: IL-1 signaling in tumor microenvironment -- Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology -- IL-9 and Th9 cells in tumor immunity -- IL-17 signaling in the tumor microenvironment -- Emerging roles for Interleukin-18 in the gastrointestinal tumor microenvironment -- IL-21 signaling in the tumor microenvironment -- ST2 signaling in the tumor microenvironment -- IL-36 Signaling in the Tumor Microenvironment -- Index
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL-21, IL-36 signaling, and more. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part A updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment
    Pages: X, 115 p. 23 illus., 22 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030383152
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  • 10
    Keywords: Cancer Research ; Stem Cells ; Regenerative Medicine ; Tissue Engineering ; Cancer Research ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Springer eBooks
    Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters
    Pages: XI, 181 p. 29 illus., 24 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030401467
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