Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Conclusions 1. The method of diene condensation of 1-alkoxy-1,3-dienes with alkylglyoxylates was used to synthesize a number of 1-alkoxy-6-carboalkoxy-Δ3-dihydropyrans. 2. It was established that the condensation of 1-ethoxy-3-methyl-1,3-butadiene cited above proceeded stereospecifically with the formation of one isomer, whereas both 1-methoxy- and 1-ethoxy-1,3-butadienes did not react stereospecificaily and gave a mixture of two possible cis-trans-isomers. 3. Considerable antiviral action was shown in a number of derivatives of 2-alkoxy-Δ3-dihydropyran (2,5-dimethoxy-6-carboethoxy-Δ3-dihydropyran, 2-ethoxy-6-carboethoxy-Δ3-dihydropyran, 2-ethoxy-6-dimethoxymethyl-Δ3-dihydropyran, 2-ethoxy-6-carboethoxy-4-methyl-Δ3-dihydropyran, and 2-ethoxy-6-carbobutoxy-4-methyl-Δ3-dihydropyran).
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