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  • 1
    Keywords: MODELS ; POPULATION ; SIGNAL ; BREAST-CANCER ; LINKAGE DISEQUILIBRIUM ; COMMON VARIANT ; susceptibility loci ; GENOME-WIDE ASSOCIATION ; GENETIC-VARIATION ; RECOMBINATION HOTSPOTS ; IDENTIFIES 5 ; MYEOV
    Abstract: Genome-wide association studies have identified prostate cancer susceptibility alleles on chromosome 11q13. As part of the Cancer Genetic Markers of Susceptibility (CGEMS) Initiative, the region flanking the most significant marker, rs10896449, was fine mapped in 10 272 cases and 9123 controls of European origin (10 studies) using 120 common single nucleotide polymorphisms (SNPs) selected by a two-staged tagging strategy using HapMap SNPs. Single-locus analysis identified 18 SNPs below genome-wide significance (P 〈 10(-8)) with rs10896449 the most significant (P = 7.94 x 10(-19)). Multi-locus models that included significant SNPs sequentially identified a second association at rs12793759 [odds ratio (OR) = 1.14, P = 4.76 x 10(-5), adjusted P = 0.004] that is independent of rs10896449 and remained significant after adjustment for multiple testing within the region. rs10896438, a proxy of previously reported rs12418451 (r(2) = 0.96), independent of both rs10896449 and rs12793759 was detected (OR = 1.07, P = 5.92 x 10(-3), adjusted P = 0.054). Our observation of a recombination hotspot that separates rs10896438 from rs10896449 and rs12793759, and low linkage disequilibrium (rs10896449-rs12793759, r(2) = 0.17; rs10896449-rs10896438, r(2) = 0.10; rs12793759-rs10896438, r(2) = 0.12) corroborate our finding of three independent signals. By analysis of tagged SNPs across similar to 123 kb using next generation sequencing of 63 controls of European origin, 1000 Genome and HapMap data, we observed multiple surrogates for the three independent signals marked by rs10896449 (n = 31), rs10896438 (n = 24) and rs12793759 (n = 8). Our results indicate that a complex architecture underlying the common variants contributing to prostate cancer risk at 11q13. We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals
    Type of Publication: Journal article published
    PubMed ID: 21531787
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 137 (1991), S. 391-407 
    ISSN: 1420-9136
    Keywords: Lüder's band ; localization ; softening ; plasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract At the onset of plastic deformation some materials exhibit non-monotonic behaviour in that after initially yielding the flow stress decreases with continuing strain, passing through a minimum. Strain softening destabilizes homogeneous configurations and results in the formation of bands of localized deformation. Within these bands the macro and microscales of the deformation overlap and accordingly terms have to be included in the evolution equation for the plastic strain to provide the necessary information on the material's behaviour at the next smaller scale. In the model chosen here the evolution equation has the form of a reaction diffusion equation, whereby physically the diffusion term accounts for the nonlocal interaction between dislocations on neighbouring slip planes. The model predicts the band propagation velocity, the width of the propagation front and the strain profile.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 233-235 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The starting material consisted of synthetic olivine (Mg2SiO4 from TEM-Pres) and a minute amount of graphite. The latter was added for absorbing the laser and thus heating the sample. The starting material was compressed in a diamond-anvil cell to about 220 kbar over a 20-min period, and the ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 294 (1981), S. 142-144 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Single crystals of San Carlos olivine, Fo92, were heated under controlled oxygen fugacity, /02, to temperatures in the range 950-1,500 C and the conductivity of the samples measured . These results indicated that the time-dependent variation in electrical conductivity was associated with a change ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 233-235 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The starting material consisted of synthetic olivine (Mg2SiO4 from TEM-Pres) and a minute amount of graphite. The latter was added for absorbing the laser and thus heating the sample. The starting material was compressed in a diamond-anvil cell to about 220 kbar over a 20-min period, and the ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Evidence for ptelotropic activation of virulence genes in Listeria monocytogenes is presented. A complementation study of a spontaneous prfA-deletion mutant and analysis of cassette and transposon insertion mutants showed that the gene prfA activates the transcription of four independent genes which code for a phosphatidyl-inositol-specific phospholipase C (gene plcA), listeriolysin O (gene hlyA), a metallo-protease (gene prtA) and a lecithinase (gene prtC). Transcription of prfA is not constitutive. During the growth phase, two peaks of prfA transcript accumulation were observed: the first was during exponential growth, and the second was at the beginning of the stationary phase. In addition, two prf4-specific transcripts of 2.2 kb and 1 kb are detected. Early in exponential growth, prfA is co-transcribed with plcA which lies upstream prfA, giving rise to the 2.2 kb plcA-prfA transcript. In late-exponential growth and at the beginning of the stationary phase, prfA transcripts of 1 kb are predominantly detected. Our results demonstrate that since prfA controls plcA transcription, it also regulates its own synthesis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-742X
    Keywords: thrombolytic therapy ; acute myocardial infarction ; patency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the safety and efficacy of the thrombolytic agent saruplase as a bolus, the angiographic and clinical outcomes of three bolus regimens were investigated in a pilot study conducted in 192 patients with an acute myocardial infarction and were compared with the standard regimen. Fifty-two patients received a double bolus of 40 mg and 40 mg after 30 minutes, 51 patients a bolus of 80 mg, and 36 patients a bolus of 60 mg. Fifty-three patients received the standard regimen (a bolus of 20 mg and 60 mg IV infusion over 1 hour). At 60 minutes TIMI 2 and 3 flow were, respectively, 9.6% and 61.5% with the 40/40-mg bolus, 15.7% and 51.0% with the 80-mg bolus, 16.7% and 30.6% with the 60-mg bolus, and 7.5% and 54.7% with the standard 20/60-mg infusion. At 90 minutes TIMI 2 and 3 flow improved to 9.6% and 73.1%, 15.7% and 56.9%, 13.9% and 36.1%, and 5.7% and 71.7%, respectively. The primary endpoint, persistent patency (TIMI 2 + 3) at 24–45 hours, was seen in 69.2%, 64.7%, 44.4%, and 67.9% of patients who had no rescue PTCA, respectively. Inclusion in the 60-mg bolus group was prematurely stopped because of their low patency rates. The 40/40-mg bolus group had the highest mortality rate (13.5%), whereas the 60-mg bolus group had no deaths. Other adverse event rates were similar in the four groups. This clinical outcome is highly influenced by rescue PTCA of patients with insufficient TIMI flow. This pilot study indicates that in patients with an acute myocardial infarction, a double bolus of 40/40 mg resulted in the highest patency but also had the highest complication rate. The 80-mg single bolus is an attractive alternative for further evaluation because of its acceptable patency and event profile, and its easy form of administration.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-7446
    Keywords: epidemiology ; goats ; multivariate analysis ; questionnaire ; seroprevalence ; sheep ; Toxoplasma gondii
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A seroepidemiological survey of Toxoplasma gondii infection in sheep and goats was conducted in the Madrid region of Spain. Sera were collected from 60 herds, for which farming management information and other relevant data for their characterization were also obtained through a questionnaire. The seroprevalence was 11.8% (64 out of 541), using the modified (2-mercaptoethanol) direct agglutination technique with a 1:64 cut-off titre. The relationship between seropositivity and the variables in the questionnaire was assessed by multivariate analysis. Four variables were found to be significantly associated with seroprevalence. Two of them, the presence of cats and a previous history of abortion outbreaks in the farm, were factors known to be linked with toxoplasmosis, indicating the validity of the serological data. Seropositivity was also related to a lack of replacements in the preceding year. Proximity to other farms appeared to be a protective factor negatively associated with seropositivity, probably because it was an indicator of proximity to an urban area and the availability of local sanitary facilities.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65N30 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary An analysis of the Babuška stability of bilinear/constant finite element pairs for viscous flow calculations is given. An unstable mode not of the checkerboard type is given for which the stability constant turns out to beO(h). Thus, the indicated spaces are not stable in general for numerical calculation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    ISSN: 0749-159X
    Keywords: Mathematics and Statistics ; Numerical Methods
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We derive stability properties and error estimates for the finite element method when used to approximate heat flow in a fluid enclosed by a solid medium. The coupled Navier Stokes system involves the Boussinesq equations in the fluid-filled cavity linked through an interface with heat conduction in the solid enclosing the fluid. As we assume no extra regularity then can be shown to hold under mild restriction on the data (at least over a small time interval in R3), we focus primarily on low order finite element spaces.
    Type of Medium: Electronic Resource
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