Lathyrus ochrus lectin
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract Conformational energy maps and descriptions of structures at the local minima are presented for the following fragments found inN-acetyllactosaminic type glycans of N-glycoproteins: GlcNAcβ(1–2)Man, GlcNAcβ(1–4)Man, GlcNAcβ(1–6)Man, Galβ(1–4)GlcNAc, GlcNAcβ(1–3)Gal, Fucα(1–6)GlcNAc, Fucα(1–3)GlcNAc, Xylβ(1–2)Man, Galβ(1–3)GlcNAc and GlcNAcβ(1–6)Gal. These results are the second part of a data bank on glycoprotein moieties; five disaccharides found in oligomannose type N-glycans were analysed earlier (Imbertyet al., 1990,Glycoconjugate J 7:27–54). In the present study, three to seven minima are found for each dimer. Conformations of disaccharide fragments found in the crystal structure of the complex of a biantennary octasaccharide withLathyrus ochrus lectin are plotted on these energy maps. While the observed conformations are at predicted minima, they are not always at the minimum predicted to have the lowest energy. Further, not all observed conformations are stabilized by the exo-anomeric effect. We conclude that these oligosaccharides are highly flexible.
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