Light-Avoidance Conditioned Response
Dark-Avoidance Conditioned Response
Springer Online Journal Archives 1860-2000
Abstract Different groups of rats were first trained with a dark avoidance conditioned schedule of the shuttle-box technique. Subsequently different doses of iproniazid and tranylcypromine were injected i.p. and their effects upon the levels of conditioning were measured according to a specific time-table, different for the two drugs. While iproniazid, at doses of 25.50 and 100 mg/kg almost always induced a decrease of the percentage of the conditioned responses, tranylcypromine, at doses of 2.5 and 5 mg/kg, caused a marked increase of the same, 5 h after its administration. Such percentage increase of the C.A.R. seems to be temporally related to the marked increase of brain nor-epinephrine induced by this latter drug, also 5 h after its administration. A comparative study between tranylcypromine and d-amphetamine shows the advantages of this particular type of schedule to distinguish between different classes of central nervous system stimulating drugs.
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