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  • 1
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Myelodysplastic syndrome ; Secondary leukemia ; Interleukin-2 ; G-CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Intensive chemotherapy followed by treatment with interleukin-2 (IL-2) was evaluated in a prospective, randomized, multicenter trial including 18 patients with refractory anemia with excess of blasts in transformation (RAEB-T), 86 patients with acute myeloid leukemia (AML) evolving from myelodysplastic syndromes, and six patients with secondary AML after previous chemotherapy. Median age was 58 years (range: 18–76 years). Forty-nine patients (45%) achieved a complete remission (CR) after two induction cycles with idarubicin, ara-C, and etoposide, 52% of them aged ≤60 years and 35% aged 〉60 years (p=0.06). After two consolidation courses, patients were randomized to four cycles of either high- or low-dose IL-2. Patients aged up to 55 years with an HLA-identical sibling donor were eligible for allogeneic bone marrow transplantation. The median relapse-free survival was 12.5 months, with a probability of ongoing CR at 6.5 years of 19%. Overall survival of all patients was 8 months, and 21 months for the CR patients. Median survival was significantly longer among patients aged ≤60 years than among the older patients (16 vs 6 months, p〈0.001). Median duration of survival and relapse-free survival were not statistically different in the two IL-2 treatment arms.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 710-717 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The growth and characterization of ZnSe epilayers on GaAs(111)B was studied. Insight into the formation mechanism of this type of surface, interface, and bulk has been provided by photoemission spectroscopy. When Zn and Se are deposited, Se reacts with As to form Se–As bonds. Therefore, the electron mean free path obtained from the intensity variation of the surface As layer is less than that from the As bulk intensity since its emission is transferred from the surface peak into chemically shifted As peak. Deposition of ZnSe results in a substrate core level shift of 0.59 eV toward lower binding energy. A value of 0.91 eV for the valence band offset, with the valence band maximum of ZnSe below that of GaAs, was obtained. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Alcoholic alkali solutions, such as potassiumt-butoxide int-butanol and potassium hydroxide in ethanol, have been known to remove the covalently bound lipid from the wool fibre surface. In this study, x-ray photoelectron spectroscopy (XPS) and secondary ion mass spectrometry (SIMS) have been used to investigate the surface characteristics of unprocessed wool fibres (both base section and weathered tips), wool fabric and the relative effects of potassiumt-butoxide and potassium hydroxide treatments. Results comparing the fibre base and tip confirm that the weathering may result in partial loss of the covalently bound lipid from the tip. In addition, a loss of sulphur has been observed. While the extent of sulphur oxidation on the surface of the base section is insignificant, the tip section may have up to 30% oxidized sulphur. There is no apparent difference between the fibres and the fabric used in this study regarding the levels of carbon, sulphur and oxidation. Potassiumt-butoxide is found to be less effective than potassium hydroxide in removing the surface bound lipid. An explanation is given which supports a hypothesis that the bound lipid is located not only at the outer most surface, but that it is also trapped within the underlying protein layer. The potassiumt-butoxide, due to its bulky molecular structure, may not have easy access to the trapped lipid. While the extent of oxidation of surface sulphur after potassiumt-butoxide treatment is higher compared to that after potassium hydroxide treatment, the levels of sulphur loss caused by these two reagents are similar. The removal of bound surface lipid for fabric is more effective than for fibres. It is suggested that fine-scale damage to the fibre, which has been observed to occur during physical processing, is responsible for this difference.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: acute non-lymphocytic leukaemia ; AIDS ; HIV infection ; myeloproliferative disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Acute myelogenous leukaemia (AML) andmyeloproliferative diseases are rare in HIV-infected individuals and optimaltreatment has not been defined. Patients and methods:We report on the cases of two HIV-infectedmen, one with AML and one with myeloid blast crisis after polycythaemia vera(PV). A comprehensive review of the available literature will be presented. Results:Patient 1, a 57-year-old bisexual man known to be HIVseropositive for more than four years (CDC-category A1), presented with apulmonary infiltrate. On admission WBC showed leukocytes 5.6 ×109/l and the differential revealed 80% blasts. A diagnosisof AML FAB M0 was made. Pneumonia resolved under antibiotic reatment and thepatient received induction chemotherapy. However, he once more developedmultiple pulmonary infiltrates and died of respiratory failure despite broadspectrum antibiotic and antimycotic therapy. Autopsy revealed pulmonaryaspergillosis. Patient 2 was a 63-year old HIV-positive hemophiliac (CDC A3)with a 10-year history of PV. On admission his white cell count showedleukocytes 256.6 × 109/l with 82% blasts.Cytochemistry revealed myelomonocytic differentiation. The patient died oftumor lysis syndrome with renal and cardio-pulmonary failure two days later. Conclusions:This is the first report of an HIV-infectedindividual with AML M0. The literature describes the cases of 39 HIV+ patientswith AML and only one further case with PV. The association of both,myeloproliferative disease and AML with HIV infection is coincidental.However, the proportion of FAB type M4/5 appears to be higher than in thegeneral population. Despite a high risk of treatment associated mortalitydurable remissions can be achieved in a small proportion of HIV-infectedpatients with AML.
    Type of Medium: Electronic Resource
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