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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 116 (1978), S. 245-252 
    ISSN: 1432-072X
    Keywords: Aspergillus duricaulis ; Cyclopaldic acid ; Polyamine/amino acid antagonist ; Ethylenediaminetetraacetate ; Bacillus subtilis ; Streptomyces viridochromogenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In the course of a screening for new metabolites from fungi we isolated a substance with antimicrobial activity from cultures of Aspergillus duricaulis (CBS 481.65) (Tü 679). It was antagonized by putrescine, spermidine, spermine, arginine, citrulline, lysine, ornithine, in higher concentration by asparagine and glutamine too. The effect of ethylenediaminetetraacetate on the susceptibility of Streptomyces viridochromogenes (Tü 57) and Bacillus subtilis ATCC 6051 to this antibiotic has been studied. The substance was characterized and identified as cyclopaldic acid.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 88 (1973), S. 25-35 
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Ein zellfreier Extrakt aus Streptomyces rimosus katalysiert die Synthese von TDP-Mycarose aus TDP-d-Glucose und S-Adenosyl-l-methionin. Die Reaktion benötigt NADPH. Das Reaktionsprodukt enthält einen weiteren methylierten TDP-Zucker unbekannter Struktur. Die Reaktion verläuft über TDP-4-Keto-6-desoxy-d-glucose als Zwischenprodukt.
    Notes: Summary A cell-free extract from mycelium of Streptomyces rimosus producing the antibiotic tylosin, catalyses the formation of TDP-mycarose from TDP-d-glucose and S-adenosyl-l-methionine. The reaction requires NADPH. The product contains a second methylated TDP-sugar with a presently unknown structure. TDP-4-Keto-6-deoxy-d-glucose is an intermediate in the reaction.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 88 (1973), S. 37-48 
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung TDP-d-Glucose-oxidoreduktase wurde aus einem Tylosin produzierenden Stamm von Streptomyces rimosus 30 fach angereichert. Das Reaktionsprodukt wurde als TDP-4-Keto-6-desoxy-d-glucose identifiziert. Einige Eigenschaften des Enzyms wurden untersucht. Die Enzymaktivität steigt in Kulturen von S. rimosus in der stationären Phase etwa gleichzeitig mit der Tylosinkonzentration und dem TDP-Mycarose synthetisierenden System an; TDP-d-Glucose-oxidoreduktase ist daher als ein am Sekundärstoffwechsel beteiligtes Enzym anzusehen.
    Notes: Summary TDP-d-glucose oxidoreductase was purified 30 fold from a tylosin producing strain of Streptomyces rimosus. The product of the enzymatic reaction is TDP-4-keto-6-deoxy-d-glucose as shown by spectral properties, chromatographic mobilities of the products obtained by chemical reduction of the nucleotide, and susceptibility of one of the reduction products to d-glucose oxidase. The enzyme has a pH-optimum of 7.2. The apparent Michaelis constant is 9.3 · 10-5 M for TDP-d-glucose. The enzyme is competetively inhibited by TMP (K i=5 · 10-3 M) and TDP (K i=6.5 · 10-5 M). Enzymatic activity is stimulated by NAD. TDP-d-glucose oxidoreductase activity increases during the stationary phase of S. rimosus together with tylosin and the TDP-mycarose synthesizing system; it is therefore regarded to be an enzyme with a function in the secondary metabolism of this organism.
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  • 4
    ISSN: 1432-072X
    Keywords: Chitin synthase ; Coprinus cinereus ; Dimilin ; Captan ; Kitazin P ; Parathion ; Nikkomycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Chitin synthase from Coprinus cinereus (Schaeff. ex Fr.) S. F. Gray (= C. lagopus sensu Buller) was used as a model for chitin synthase from insects. The effect of dimilin (difluorobenzuron), captan (trichloromethylsulfonyl fungicide), kitazin P (organophosphorus ester fungicide) and parathion (organophosphorus insecticide) on the fungal enzyme was compared with the effect of nikkomycin (nucleoside-peptide antibiotic).
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  • 5
    ISSN: 0031-9422
    Keywords: 19-hydroxycoronaridine ; 19-hydroxyibogamine. ; Apocynaceae ; Tabernaemontana glandulosa ; antibiotic activity ; ibogamine alkaloids
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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