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  • 1
    Call number: WN185:14(2) ; E020:81 ; E040:152
    Keywords: Magnetic Resonance Imaging ; Physical Phenomena
    Pages: 944 p. : ill.
    Edition: 2nd edition.
    ISBN: 9780471720850
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    WN185:14(2) available
    E020:81 departmental collection or stack – please contact the library
    E040:152 departmental collection or stack – please contact the library
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  • 2
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441972163
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  • 3
    Call number: D0200:104
    Keywords: Drug resistance in cancer cells / Research ; Drug Resistance, Neoplasm ; Antineoplastic Agents / pharmacology ; DNA Damage ; Genetic Techniques
    Pages: xi, 238 p. : ill.
    ISBN: 0896036030
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    D0200:104 departmental collection or stack – please contact the library
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  • 4
    Unknown
    New York : McGraw-Hill, Medical Pub. Division
    Call number: C050:30
    Keywords: Nervous System Diseases ; Mental Disorders
    Notes: Rev. ed. of: Adams and Victor's principles of neurology / Maurice Victor, Allan H. Ropper. 7th ed. c2001.
    Pages: x, 1382 p. : ill., port.
    Edition: 8th ed.
    ISBN: 007141620X
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    C050:30 departmental collection or stack – please contact the library
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  • 5
    ISSN: 1573-7691
    Keywords: Domain decomposition ; nested dissection ; LU-factorization ; time integration ; Newton's method ; spectral elements ; finite elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Domain decomposition by nested dissection for concurrent factorization and storage (CFS) of asymmetric matrices is coupled with finite element and spectral element discretizations and with Newton's method to yield an algorithm for parallel solution of nonlinear initial-and boundary-value problem. The efficiency of the CFS algorithm implemented on a MIMD computer is demonstrated by analysis of the solution of the two-dimensional, Poisson equation discretized using both finite and spectral elements. Computation rates and speedups for the LU-decomposition algorithm, which is the most time consuming portion of the solution algorithm, scale with the number of processors. The spectral element discretization with high-order interpolating polynomials yields especially high speedups because the ratio of communication to computation is lower than for low-order finite element discretizations. The robustness of the parallel implementation of the finite-element/Newton algorithm is demonstrated by solution of steady and transient natural convection in a two-dimensional cavity, a standard test problem for low Prandtl number convection. Time integration is performed using a fully implicit algorithm with a modified Newton's method for solution of nonlinear equations at each time step. The efficiency of the CFS version of the finite-element/Newton algorithm compares well with a spectral element algorithm implemented on a MIMD computer using iterative matrix methods.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-9686
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Decreasing pleural pressure impedes the ejection of blood from the left ventricle (LV), may lead to decreased LV compliance because of interdependence effects and leads to increased transmural LV systolic and diastolic pressure. Previous work from this laboratory has shown that patients with coronary artery disease (CAD) often develop akinetic segments of the LV wall during the Mueller maneuver. In the presence of increased LV transmural pressure regional akinesis could be caused either by the development of regional ischemia or by mechanical inhibition of motion of an area of nonfunctional myocardium as would be caused by previous myocardial infarction (MI). The present study was designed to distinguish between these two mechanisms by determining if the presence of CAD alone is sufficient to lead to regional akinesis or if prior MI is necessary. We used first pass radionuclide ventriculography (RVG) in the 30° LAD supine position to measure LV ejection fraction (EF), end-diastolic (EDV) and end-systolic (ESV) volumes, heart rate and to assess regional wall motion during the Mueller maneuver. This was done in four groups of subjects: (1) 13 normal subjects, (2) 25 patients with CAD but no prior MI, (3) 13 patients with prior nontransmural MI and (4) 36 patients with prior transmural MI. All subjects had angina pectoris and underwent contrast coronary arteriography. Most also underwent routine contrast left ventriculography as well. There were no significant differences among the three patient groups as regards medications, extent and severity of CAD, and response to routine exercise tolerance testing. EF decreased significantly in the three patient groups (4%–9%, p〈0.01) but not in the normals during the Mueller maneuver. Heart rate increased (5–10 bpm, p〈0.05) in the normals and in patient groups 2 and 4. EDV decrease in all four subject groups (8%–10%, p〈0.01), while ESV remained unchanged. Akinesis of the LV wall developed during the Mueller maneuver only in one group-2 patient, but did so in 17/36 patients with prior transmural MI (group 4, p〈0.001). One-half of the akinetic LV wall segments seen during the Mueller maneuver on RVG were not seen on routine contrast ventriculography. We tested the effects of posture (supine versus upright) on the response to the Mueller maneuver in six normal subjects and found no changes in the response of EDV and ESV to the Mueller maneuver. We conclude that (1) the appearance of LV wall akinesis during the Mueller maneuver signifies the presence of prior transmural MI, and not just CAD; (2) the Mueller maneuver can enhance the sensitivity of the RVG for detecting nonfunctional myocardium; (3) regional akinesis develops even when LV volume decreases, suggesting it is due to changes in LV transmural pressure; (4) there are changes in LV function which can lead to a decrease in global EF during the Mueller maneuver; (5) the effects of the Mueller maneuver on LV volume are complex, variable and are subject to multifactorial influences.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-7691
    Keywords: Domain decomposition ; nested dissection ; LU-factorization ; parallel computers ; MIMD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract A multilevel algorithm is presented for direct, parallel factorization of the large sparse matrices that arise from finite element and spectral element discretization of elliptic partial differential equations. Incomplete nested dissection and domain decomposition are used to distribute the domain among the processors and to organize the matrix into sections in which pivoting is applied to stabilize the factorization of indefinite equation sets. The algorithm is highly parallel and memory efficient; the efficient use of sparsity in the matrix allows the solution of larger problems as the number of processors is increased, and minimizes computations as well as the number and volume of communications among the processors. The number of messages and the total volume of messages passed during factorization, which are used as measures of algorithm efficiency, are reduced significantly compared to other algorithms. Factorization times are low and speedups high for implementation on an Intel iPSC/860 hypercube computer. Furthermore, the timings for forward and back substitutions are more than an order-of-magnitude smaller than the matrix decomposition times.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-4994
    Keywords: Fluorescence ; anomalous fluorescence ; 4-N,N-dimethylaminobenzoic acid ; dimerization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract 4-N,N-Dimethylaminobenzoic acid exhibits anomalous fluorescence in polar and hydrogen-bonding solvents. The fluorescence spectra and kinetics suggest that this arises due to the formation of a ground-state dimer or higher polymer. Preliminary measurements in hexane containing small amounts of polar acetonitrile do not rule out the possibility of exciplex formation also occurring.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Recently, point mutations in superoxide dismutase 1 (SOD1) have been shown to lead to a subset of autosomal dominantly inherited familial amyotrophic lateral sclerosis (ALS). These findings have led to the hypothesis that defects in oxygen radical metabolism may be involved in the pathogenesis of ALS. Therefore, we decided to analyze other enzymes involved in oxygen radical metabolism for possible involvement in other forms of ALS. We report here analysis of two genes encoding the molybdenum hydroxylases aldehyde oxidase (AO) and xanthine dehydrogenase/ oxidase (XDH) for involvement in ALS. Of particular interest, one gene identified as encoding aldehyde oxidase is shown to map to 2q33, a region recently shown to contain a gene responsible for a familial form of ALS with autosomal recessive inheritance (FALS-AR). The AO gene appears to be located within 280,000 bp of simple sequence repeat marker D2S116, which shows no recombination with the FALS-AR locus. The AO gene is highly expressed in glial cells of human spinal cord. In addition, we mapped a gene for XDH to 2p22, a region previously shown to contain a highly homologous but different form of XDH. Neither of these XDH genes appears to be highly expressed in human spinal cord. This evidence suggests that AO may be a candidate gene for FALS-AR.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-1472
    Keywords: Boundary-layer model ; Mixed-layer dynamics ; Organized large eddies ; Ekman flow ; Cold-air outbreak
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The internal thermal boundary layer developing over the Mediterranean during a cold-air outbreak associated with a Tramontane event has been studied by means of airborne lidar, in situ sensors, and a modelling approach that consisted of nesting the University of Washington (UW) planetary boundary-layer (PBL) model in an advective zero-order jump model. This approach bypasses some of the deficiencies associated with each model: the absence of the dynamics in the mixed layer for the zero-order jump model and the lack of an inversion at the PBL top for the UW PBL model. Particular attention is given to the parameterization of the entrainment flux at the PBL top. Values of the entrainment closure parameter derived with the model when matching PBL structure observations are much lower than those derived with standard zero-order jump models. They also are in good agreement with values measured in different meteorological situations by other studies. This improvement is a result of the introduction of turbulent kinetic energy production in the mixed layer.
    Type of Medium: Electronic Resource
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