Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  125. Kongress der Deutschen Gesellschaft für Chirurgie; 20080422-20080425; Berlin; DOC08dgch9668 /20080416/
    Publication Date: 2008-04-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: PEPTIDE ; CELLS ; IN-VITRO ; CELL ; COMBINATION ; Germany ; VITRO ; SYSTEM ; MICE ; TIME ; ACTIVATION ; MECHANISM ; MARKER ; INDUCTION ; animals ; ANTIGEN ; DENDRITIC CELLS ; mechanisms ; T cell ; T cells ; T-CELL ; T-CELLS ; TOLERANCE ; MOLECULE ; DELETION ; NERVOUS-SYSTEM ; TRANSGENIC MICE ; PROGRESSION ; NUMBER ; MARKERS ; CENTRAL-NERVOUS-SYSTEM ; MULTIPLE-SCLEROSIS ; T lymphocytes ; AUTOIMMUNE ENCEPHALOMYELITIS ; AUTOIMMUNITY ; thymus ; THYMIC EPITHELIAL-CELLS ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; MS ; multiple sclerosis ; immunology ; regulatory T cells ; animal ; nervous system ; central nervous system ; ANTIGEN RECOGNITION ; AUTOREACTIVE T-CELLS ; BASIC-PROTEIN GENE ; CD4(+) T cell ; RECEPTOR-ALPHA CHAINS ; TOLERANCE INDUCTION
    Abstract: Most autoantigens implicated in multiple sclerosis (MS) are expressed not only in the central nervous system (CNS) but also in the thymus and the periphery. Nevertheless, these autoantigens might induce a strong autoimmune response leading to severe destruction within the CNS. To investigate the influence of a dominantly presented autoantigen on experimental autoimmune encephalomyelitis (EAE), we generated transgenic mice expressing the autoantigenic peptide MBP1-10 covalently bound to the MHC class II molecule I-A(u). These mice were crossed either with B10.PL or with TCR-transgenic Tg4 mice, specific for the transgenic peptide-MHC combination. In double transgenic mice we found strong thymic deletion and residual peripheral T cells were refractory to antigen stimulation in vitro. Residual peripheral CD4(+) T cells expressed activation markers and a high proportion was CD25 positive. Transfer of both CD25-negative and CD25-positive CD4(+) T cells from double transgenic animals into B10.PL mice strongly inhibited the progression of EAE. Despite this thorough tolerance induction, some double transgenic mice developed severe signs of EAE after an extended period of time. Our data show that in the circumstances where autoantigenic priming persists, and where the number of antigen-specific T cells is high enough, autoimmunity may prevail over very potent tolerance-inducing mechanisms
    Type of Publication: Journal article published
    PubMed ID: 16361316
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  125. Kongress der Deutschen Gesellschaft für Chirurgie; 20080422-20080425; Berlin; DOC08dgch8992 /20080416/
    Publication Date: 2008-04-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  124. Kongress der Deutschen Gesellschaft für Chirurgie; 20070501-20070504; München; DOC07dgch6969 /20071001/
    Publication Date: 2007-10-02
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 0169-4332
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 4 (1980), S. 203-207 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les lésions péri-anales sont fréquentes dans la maladie de Crohn. Elles peuvent être le premier signe de la maladie. Mais la plupart d'entre elles sont ou deviennent asymptomatiques et peuvent le rester pendant plusieurs années. Nous avons suivi pendant 10 ans 109 malades atteints de fissures ou fistules anales. Quatorze patients sont décédés, 7 d'entre eux d'affections sans relation avec le Crohn. Dans 10 cas, une amputation du rectum a été réalisée, mais les lésions anales ne constituaient l'indication de cette exérèse que dans 5 cas. Sur les 85 cas restants, 24, sans aucun symptome, n'ont pas été réexaminés, 61 ont été étudiés par rectoscopie, biopsie ou manométrie. De nombreuses fissures et la majorité des fistules étaient cicatrisées; certaines avaient entraîné une sténose anale, en général modérée et asymptomatique. Nous estimons donc que le traitement doit être conservateur.
    Notes: Abstract Perianal disease is a frequent manifestation of Crohn's disease and occasionally is the presenting symptom. However, most lesions are or become asymptomatic and remain so for many years. A series of 109 patients with perianal fissures and fistulas has been followed for 10 years. Fourteen have died, 7 from unrelated disorders. Ten have had an excision of the rectum but only 5 for perianal disease. Of the remaining 85 patients, 24 asymptomatic patients were not reexamined, and 61 were investigated extensively by sigmoidoscopy biopsy or manometry. Many fissures and most fistulas had healed, but some had progressed to some degree of anal stenosis, usually asymptomatic. A very conservative policy is proposed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1433-8580
    Keywords: Hernioplasty ; Incisional hernia ; Heteroplasty ; Hernienplastik ; Narbenbruch ; Fremdmaterial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Tierexperiment wurde das mit Glutaraldehyd fixierte bovine Perikard auf Eignung zur plastischen Versorgung großer Bauchwanddehiszenzen geprüft und mit dem oft verwendeten Mersilene-Netz verglichen. Die mechanischen Eigenschaften beider Fremdmaterialien wurden durch Messung von Bruchdehnung und Reißkraft sowohl in vitro wie auch nach Implantation untersucht. Die Ergebnisse zeigen, daß das bovine Perikard für die Versorgung großer Bauchwanddefekte geeignet ist und wegen der wesentlich geringeren Adhäsionenbildung mit den Intestinalorganen dem Mersilene-Netz überlegen ist.
    Notes: Summary We compared glutaraldehyde-fixed bovine pericardium with conventional Mersilene mesh with regard to suitability for repair of large incisional hernias in canine experiments. To test the materials the force needed to rupture them and the percentage of stretching to the breaking point were determined both in vitro and after implantation. The results showed that bovine pericardium is a suitable material for repair of large incisional hernias. Pericardium is superior to Mersilene mesh because of its minimal formation of adhesions with the underlaying bowel.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1433-8580
    Keywords: Esophagostomy ; Duodenostomy ; Gastric secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modified Komarov-Marks esophagostomy is described. It was the aim of our experiments to show that this procedure does not harm the vagal innervation of the stomach. The vagal function was assessed by testing (1) basal secretion, (2) 2-deoxy-D-glucose-stimulated secretion, (3) pentagastrin-stimulated secretion, and (4) serum gastrin levels in five mongrel dogs. Each test was performed at least three times in each dog before and after the esophagostomy procedure, respectively. The secretion rates were not affected by surgery. It is concluded that cervical esophagostomy in dogs does not affect vagal stimulation of gastric acid secretion. For the application of tracer substances into the duodenum, two types of conduits are described: (1) a short jejunal segment and (2) a jejunal segment with an invagination valve. The pros and cons of these procedures are discussed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1433-8580
    Keywords: Vagotomy, proximal selective ; Esophagus, blood circulation ; Duodenal ulcer ; Vagotomie, proximale selektive ; Oesophagus, Blutzirkulation ; Duodenales Ulcus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer tierexperimentellen Studie wird die Auswirkung der proximal selektiven Vagatomie (PSV) mit anschließender Skelettierung von Teilen des Oesophagus auf die Oesophagusdurchblutung untersucht. Unter den 6 Hunden mit PSV und Oesophagusskelettierung bis zur oberen Thoraxapertur trat einmal eine Nekrose mit Perforation im distalen Oesophagus auf. Die restlichen 5 sowie die 4 Hunde, welchen nach der PSV nur der distale Oesophagus denudiert worden war, zeigten keine Anzeichen einer Durchblutungsstörung. Anhand der Literatur wird auf die Blutversorgung der menschlichen Speiseröhre eingegangen und die Übertragbarkeit der Resultate vom Hund auf den Menschen diskutiert. Einer Ausdehnung der Skelettierung des Oesophagus zur Vervollständigung der PSV steht von seiten der Durchblutung nichts im Wege.
    Notes: Summary The influence of the proximal selective vagotomy (PSV) with following skeletisation of parts of the esophagus on its circulation was investigated in an animal experimental study. Among the 6 dogs with PSV and skeletisation of the esophagus up to the upper thorax apertura one was seen with necrosis and perforation in the distal part of the esophagus. The last 5 dogs and the 4 dogs in which after the PSV only the denudation of the distal part of the esophagus was carried out no signs of circulatory disturbance were seen. The blood circulation in human esophagus, as described in the literature, and the transfer of the results from dogs to human is discussed. An enlarged skeletisation of the esophagus in order to improve the completeness of the PSV does not harm blood circulation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 177 (1980), S. 173-176 
    ISSN: 1433-8580
    Keywords: Gastroduodenal physiology ; External duodenal approach ; Continence by invagination valve ; Gastroduodenale Physiologie ; duodenaler Zugang ; Kontinenz durch Invaginationsventil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim Hund hat sich als Zugang zum Duodenum für experimentelle Zwecke ein Dünndarminterponat bewährt. Allerdings verursacht der Sekretverlust aus dieser Fistel unangenehme Nebenwirkungen. Wird das Dünndarmsegment mit einem Invaginationsventil versehen, so wird der Zugang kontinent und läßt trotzdem eine einfache Sondierung des Duodenums zu.
    Notes: Summary An established method for the experimental approach to the duodenum in the dog is the interposition of a segment of small bowel. However, the leakage of intestinal fluid causes unpleasant side effects. By the invagination within the intestinal segment a valve can be constructed which provides both continence and easy access.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...