Blackwell Publishing Journal Backfiles 1879-2005
Salmonella ushB, which encodes a membrane-bound UDP-sugar hydrolase, has an Escherichia coli orthologue (ushBc) which does not detectably produce this activity. In this report, we show that ushBc does not produce any detectable protein either, despite being transcribed normally. Remarkably, ushBc is shown to have 100% sequence identity with E. coli cdh, previously characterised as encoding an active CDP-diglyceride hydrolase, an apparent contradiction with implications regarding enzyme evolution. We suggest that a useful gene designation is cdh (ushBc) rather than either ushBc or cdh, alone.
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