Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Unknown
    Washington, DC: Armed Forces Institute of Pathology
    Associated volumes
    Call number: QZ241:9/10
    Keywords: Tumor / Hirn ; Tumor / Nervensystem ' Zentral ; Tumor / Atlas
    Pages: 452 p., zahlr. ill.
    ISBN: 1-881041-10-7
    Signatur Availability
    QZ241:9/10 available
    BibTip Others were also interested in ...
  • 2
    Call number: QZ241:3(2)/21
    Keywords: Central nervous system / Tumors ; Tumors / Classification ; Neoplasms, Nervous Tissue / classification ; Neoplasms, Nervous Tissue / pathology ; Neoplasms, Nervous Tissue / pathology ; Central Nervous System Neoplasms / classification ; Central Nervous System Neoplasms / pathology ; Central Nervous System Neoplasms / pathology
    Notes: Rev. ed. of: Histological typing of tumours of the central nervous system / K.J. Zülch, in collaboration with pathologists in 14 countries. 1979.
    Pages: xii, 112 p. : col. ill.
    Edition: 2nd ed.
    ISBN: 3540569715
    Signatur Availability
    QZ241:3(2)/21 available
    BibTip Others were also interested in ...
  • 3
    Unknown
    Washington, D.C. : American Registry of Pathology in collaboration with the Armed Forces Institute of Pathology
    Associated volumes
    Call number: QZ241:10/7
    Keywords: Central nervous system / pathology
    Pages: xiv, 596 p. : ill. (some col.)
    ISBN: 9781933477015
    Signatur Availability
    QZ241:10/7 available
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-2307
    Keywords: Medulloblastoma ; DNA ; Microfluorometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A microfluorometric analysis was performed to analyse the DNA content of 42 medulloblastomas (MBs) and to seek correlations, if any existed, between the DNA distribution and ploidy values, neoplasm types (i.e. classic vs desmoplastic), histological features of aggressiveness, and immunocytochemical features indicating glial and/or neuronal differentiation. Thirty-one cases were classified as classic and 11 cases as desmoplastic MBs. Ten of 11 desmoplastic MBs had a near-diploid main mode and the remaining 1 case had a near-tetraploid main mode. Moreover, 10 of 11 (90%) cases showed a “monomodal” DNA distribution diagram. All these cases showed a uniform histology. In contrast, classic MBs represented a heterogeneous group of neoplasms. Twenty-two cases were near-diploid, 5 cases were near-tetraploid and 3 cases were near-triploid. The histogram type distribution showed a similar heterogeneity. Twelve of 31 (39%) cases had a monomodal histogram, 12 (39%) cases had a bimodal diagram and 7 (22%) cases a complex DNA distribution. There was a statistically significant difference (P〈0.001) in terms of prevalence of DNA monomodal histograms between classic and desmoplastic MBs. Significant correlations were not observed among classic MBs between histological features of aggresiveness, type and degree of differentiation and DNA distribution. The present study indicates that desmoplastic MBs represent a homogeneous group of neoplasms in terms of histology and DNA distribution. In contrast, classic MBs are lesions with different degrees of histologically apparent aggressiveness and a complex DNA distribution.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1433-0350
    Keywords: Key words Craniopharyngioma ; Brain neoplasms ; Children ; Surgery ; Radiotherapy ; Relapse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Past studies of craniopharyngiomas in children have shown overall survival (OS) up to 95% at 5 years and 80% progression-free survival (PFS) at 5 years, although many of these series predate modern neuroimaging and current therapeutic management. Moreover, little mention has been made of failure patterns for craniopharyngioma in children. To obtain a contemporary assessment of outcome among pediatric craniopharyngioma patients, and also to determine the failure patterns for this tumor, we completed a retrospective study of a consecutive cohort of all children with craniopharyngioma diagnosed at the Johns Hopkins Hospital from 1980 to 1996. Resection was performed in 30 children, in 8 of whom gross total resection (GTR) was achieved. Initial treatment took the form of GTR followed by observation for 8, subtotal resection (STR) plus observation in 11, and STR followed immediately by radiotherapy in 8. The timing of radiotherapy following STR was unclear for 3. OS was 95.2% (SE= 4.7%) at 5 years, with only 2 children dying after 4 years from diagnosis. Five-year PFS was 59.4% (SE=10.2%). Before surgery, 19 children had visual loss and 15, endocrine deficits; after surgery, 21 children had visual loss and 29, endocrine deficits. Median time to relapse was 0.98 years (SD=2.5 years). Radiographic (n=4) and clinical (n=7) relapses did not differ in time to progression (P=0.32), but radiographic relapses were significantly associated with age at diagnosis less than 5 years (P=0.02). Degree of resection was not significantly associated with PFS (P=0.32) or with postoperative visual or endocrine deficits. Absence of calcification on diagnostic neuroimaging (n=8) was significantly associated with improved PFS [5-year PFS 100% vs. 42.9% (SE=14.7%), P=0.02], even when adjusted for extent of resection (P=0.03). Preoperative visual loss was predictive of postoperative visual loss (P=0.03). Survival for children diagnosed with craniopharyngioma in the current era is outstanding, even with relapse, although postoperative visual and endocrinological morbidities are high. Failures occurred both radiographically and clinically, typically in the first 3–4 years after surgery, suggesting a need for close surveillance initially with neuroimaging, particularly in younger children, and also clinical examination. The short times to relapse observed here may stem from a tendency to delay radiotherapy until recurrence. Lack of calcification at diagnosis is associated with a tendency to remain free of relapse.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1433-0350
    Keywords: Proliferating cells ; Growth fraction ; Ki-67 monoclonal antibody ; Pediatric brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using the monoclonal antibody Ki-67, proliferating cells were demonstrated immunohistochemically in 16 tumors of the nervous system in children, and these findings compared with those in 44 adult tumors. The antibody, which reacts with a nuclear protein expressed during the G1, S, G2, and M phases of the cell cycle, was demonstrated in frozen (13 cases) or smear (3 cases) sections using the peroxidase-antiperoxidase method. The percentage of stained tumor cells in children was in general agreement with the histological grade, ranging from 0.2% in a schwannoma to 12.4% in a juvenile type of glioblastoma. In a medulloblastoma, the fraction of labeled nuclei was 10.2%. In malignant gliomas of children, the percentage of stained cells did not differ from that in adult tumors. However, some cases demonstrated an unusually higher number of positive cells associated with higher cellularity than did adult tumors; this is in agreement with the content of small immature tumor cells in many pediatric tumors. The use of Ki-67 staining could become an important additional criterion for predicting the biologic behavior of nervous system neoplasms in children.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-0533
    Keywords: Experimental Brain Tumor ; Glioma ; Astrocytoma ; Avian Sarcoma Virus ; Nexus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain tumors were induced in inbred PD4 hamsters with each of four strains of Avian Sarcoma Virus: CT-559, Bratislava-77, Schmidt-Ruppin, and Bryan. Based on light and electron microscopic observations the neoplastic tissues found in these tumors were identified as: (1) glial, (2) a distinctive large cell, and (3) sarcomatous. The glial neoplasms consisted almost entirely of masses of astrocytes in a subependymal position. The large cell tissue was a striking feature in some of the tumors. Although the cell of origin for this tissue could not be positively identified, certain features suggested that these cells were derived from glia. The cerebral sarcomas occurred as small nodules near the pial surface or occasionally as large intracerebral masses. Replicating virus was not seen in any of the tumors.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-0533
    Keywords: Glioma ; Neovascularization ; Endothelium ; Vascular smooth muscle ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the origin of cells contributing to microvascular proliferation (MVP) in glial neoplasms is unsettled, a light microscopic and immunohistochemical study for vascular smooth muscle cells and endothelial cells was performed in formalin-fixed, routinely processed brain tumor biopsy material. MVP in glial neoplasms was compared with that in intracerebral metastatic carcinomas and in intracranial granulation tissue. On the basis of the degree of hyperplasia of hypertrophic cells in the microvascular wall, MVP was subjectively divided into mild, moderate, and glomeruloid (marked) proliferation. The relative contribution of vascular smooth muscle cells and endothelial cells to different degrees of MVP was estimated immunohistochemically using antibodies against α-smooth muscle actin and von Willebrand factor, respectively. Glomeruloid MVP occurred in 50% of the malignant glial neoplasms. Moderate MVP was found in most malignant gliomas and in some pilocytic astrocytomas. Glomeruloid MVP was present in peritumoral glial tissue in 4 out of 15 intracerebral metastatic carcinomas, while only mild to moderate MVP was found within these tumors. In granulation tissue MVP was mild. In glomeruloid and moderate MVP vascular smooth muscle cells were more hypertrophic and more numerous than endothelial cells. The contribution of hypertrophic vascular smooth muscle cells to mild MVP was variable. MVP in glial neoplasms was generally not accompanied by a matrix of fibrous stroma but was directly embedded in glial tissue. The architecture of this MVP suggested “in situ” proliferation of microvascular cells without migration of these cells into the surrounding tissue.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1615-5742
    Keywords: Key words: brain neoplasms, pediatric tumors, primitive neuroectodermal tumors, rosette
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have encountered a series of seven unusual neuroblastic pediatric central nervous system (CNS) neoplasms with a unique constellation of histologic, immunohistochemical, and ultrastructural features. The tumors presented in five girls and two boys, ages 1 to 3 years. In six cases the lesions involved the frontoparietal region, in one case the tectal plate. The tumors consisted of small to medium-sized, round to oval, hyperchromatic cells with poorly defined cytoplasmic borders. Cells were found in clusters and cords set in a paucicellular fibrillar neuropil matrix. Distinctive, virtually anuclear regions of neuropil were scattered throughout the lesions. True rosettes with well-formed central lumens often filled with granular debris were present, along with perivascular pseudorosettes and occasional Homer-Wright rosettes. Mitoses and apoptosis were frequent, but large regions of confluent necrosis were absent. Immunohistochemically, the neuropil-like areas as well as the perinuclear cytoplasm of many embryonal tumor cells were positive for synaptophysin and neurofilament protein. Ultrastructurally, the tumor cells showed microtubule-containing neuronal processes, some with neurosecretory granules. While the lesions were largely glial fibrillary acidic protein (GFAP) negative, there was focal GFAP positivity consistent with divergent differentiation in one case. The clinical outcome was poor, with five patients dead from their disease 5 to 14 months after initial presentation and one patient with recurrent disease 7 months after resection and chemotherapy. The final patient is alive without recurrent disease 30 months after initial presentation. These lesions present distinctive histological features within the group of primitive neuroectodermal tumors.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with structurally ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...