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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds505 /20070906/
    Publication Date: 2007-09-07
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  21. Wissenschaftliche Jahrestagung der DGPP; 20040910-20040912; Freiburg/Breisgau; DOC04dgppV10 /20040909/
    Publication Date: 2004-09-09
    Description: Das Neugeborenen-Hörscreening ist in den letzten Jahren in vielfältiger Form im In- und Ausland erprobt worden. Während die Zielvorgaben sich gleichen, sind die Organisationsformen einzelner Länder bzw. Kliniken grundsätzlich verschieden. Mit dem Modellprojekt soll ein Weg aufgezeigt werden, inwieweit eine flächendeckende Einführung des Screenings in die sozialen Strukturen unseres Gesundheitssystems machbar, effektiv und effizient ist. Die Durchführung des Screenings ist in den Geburtskliniken durch die Kinderkrankenschwestern sehr gut möglich. Die Refer - Rate kann durch direkt nachfolgende Retets, selbst bei inzwischen immer kürzeren Liegezeiten unter 2 % liegen. Das Screening führt zu einer signifikanten Absenkung des Entdeckungsalters einer vorliegenden Schwerhörigkeit. Gleichzeitig können mehr Kinder mit einer therapierelevanten Schwerhörigkeit insgesamt entdeckt werden. Die Inzidenz liegt bei ca. 0,9:1000 Neugeborenen. Die Abklärungsdiagnostik erfolgte zumeist bis zum Ende des dritten Lebensmonats. Die Einleitung der Therapie bis zum Ende des sechsten Lebensmonats konnte nur teilweise gewährleistet werden. Die Gesamtkosten des Screenings pro Fall liegen bei ca. 16 Euro. Insgesamt erweist sich das Neugeborenen-Hörscreening als kosteneffektiv und effizient.Um den Vorteil der frühen Erfassbarkeit von Hörstörungen zu nutzen, ist eine Screening-Zentrale erforderlich. Deren Aufgabe u. a. sind die Einführung des Screenings, die Schulung des Personals, die Überprüfung der Effektivität und Effizienz.
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds921 /20070906/
    Publication Date: 2007-09-07
    Keywords: nutzerorientierte Versorgung ; Prävention ; Patientenautonomie ; gemeinsame Entscheidungsfindung ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Atopic dermatitis (AD) is a common skin disease in childhood. Micro- and macro-environmental factors have not yet been studied simultaneously in a large cohort of the same area in detail. Objectives The incidence of AD was investigated in 97% of all school entrants (n = 4219) in the city of Hannover, Germany, with regard to the influence of individual and environmental factors. Methods A standardized questionnaire based on the criteria of Hanifin and Rajka that has the sensitivity and specificity of 97% compared with the clinical diagnosis of a dermatologist and a logistic regression model were used. Multiple local-based environmental factors were analysed for all 49 city quarters. Results Of all children studied, 10·5% suffered from AD at some time in their lives. The frequency of AD was significantly increasing with more privileged socio-economic status (P 〈 0·01). Independent factors that were associated with a higher frequency of AD were German nationality (12·4% AD compared with 2·1% in non-German), higher paternal socio-economic status (i.e. father's profession), higher daily duration of the fathers' professional work and the lack of paternal shift work. In contrast, there was no significant association between the frequency of AD and local environmental factors such as the biological effective level of air pollution and urbanization. Conclusions In conclusion, we confirm an association between a privileged life-style and a higher incidence of AD in a large number of investigated children between 5 and 9 years of age (97·6% of children were 6 or 7 years old) for the German city of Hannover. We propose the socio-economic status as a marker for different life-styles and social micro-environments in further studies as there were multiple significant correlations between individual social and environmental factors. The macro-environment seems to be less important for the disease outcome in this context.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0022-3999
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1569-8041
    Keywords: ATase ; breast cancer ; drug resistance ; PGP ; GPx ; GSH ; GST ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The identification of new factors predicting relapse,outcome and response to systemic therapy in breast cancer is warranted. Themeasurement of biological markers such as drug resistance parameters (DRPs),which are part of the phenotype of malignant cells and contribute toresistance to anti-cancer drugs may be a possibility, which may ultimatelylead to improvement of therapeutic results. Patients and methods: The level of glutathione (GSH), activities ofglutathione-S-transferase (GST), glutathione-peroxidase (GPx),06-alkylguanine-DNA-alkyltransferase (ATase), and P-glycoprotein (PGP) weremeasured in tumor and adjacent tumor free tissue samples from 89 consecutive,untreated females with breast cancer and correlated with clinical andprognostic factors. Early breast cancer (EBC) was diagnosed in 56 patients,22 patients had locally advanced (LABC) and 11 patients metastatic breastcancer. Results: All DRPs showed significantly higher expression in tumorthan in tumor free tissues. GPx was positively correlated with GST (R = 0.3, P = 0.0048) and with GSH (R = 0.5, P = 0.0001) in tumor as wellas in normal tissue. GST activity was significantly higher in EBC than in LABCor metastatic breast cancer ( P = 0.02). GSH level was significantlyhigher in grade 1 than in grade 2 or grade 3 tumors ( P = 0.01). Whenclinical characteristics were related to the level of DRP, ‘high’ GSH wasassociated with age 〉60 years ( P = 0.01) in EBC, and with grade1–2 tumors ( P = 0.05) in LABC. No differences in OS were apparentbetween groups of ‘high’ and ‘low’ DRP-expression. However, the four-yearestimated disease-free survival of EBC tended to be higher in patients with‘high GST ( P = 0.10) and of LABC in patients with ‘high’ GPx levels( P = 0.06). Conclusion: We conclude that ‘high’ levels of DRP in tumor tissue ofbreast cancer patients are part of the initial phenotype of the malignantcells. Due to its high prevalence (83% in EBC, 100% in primarilymetastatic breast cancer), PGP did not add to prognostic information. Highlevels of GSH, GST and and GPx were associated with favorable clinicalcharacteristics and good prognosis, whereas low levels of GSH and GST activitywere associated with more aggressive or more advanced disease.
    Type of Medium: Electronic Resource
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