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  • 1
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary VIP- and substance P-like immunoreactivities were found in considerable concentrations (VIP: 17.3±4.8 pmol/g, mean ± SEM; substance P:11.1±1.8 pmol/g) in the uveal portion of the guinea pig eye.d Immunocytochemistry localised these two regulatory peptides to nerve fibres found principally in a plexus in the iris (substance P) and in an extensive network surrounding the blood vessels of the choroid (VIP). A remarkable anatomical demarcation of the two types of peptide-containing nerves was established by the staining of substance P-containing nerves, which stops at the level of the ciliary body. This uveal area is known to be involved in the ocular responses to nociceptive stimuli. At the ultrastructural level, immunoreactivity for both peptides was localised to distinct subpopulations of p-type nerves, distinguishable by the size of their large dense-cored vesicles. Those immunoreactive for VIP were significantly larger (p〈0.0005) than those immunoreactive for substance P (95±7 nm and 82±9 nm respectively; mean ± SD). Interruption of the trigeminal pathway produced a remarkable decrease of substance P immunoreactivity in the anterior portion of the uvea (9.1±1.5 pmol/g, mean ± SEM, control; 5.3±1.3 pmol/g, denervated), but not of VIP immunoreactivity in the choroid. Following colchicine treatment, VIP-immunoreactive neuronal cell bodies were localised in the choroid. The separate anatomical localisations and distributions of the two uveal peptides appear to be related to their different origins and functional roles in the response of the eye to noxious stimuli.
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  • 2
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Recombination has been demonstrated in amyloglucosidase-producing strains of Aspergillus niger. A high-yielding strain has been crossed, parasexually, with a low-yielding strain from the same genealogy. Recombinants have been produced, having the efficient broth filtration characteristics of the low-yielding strain. One such segregant was superior, for the industrial production of amyloglucosidase, to the best parent strain previously used for that purpose.
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  • 3
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty patients with mycosis fungoides were treated with photochemotherapy using oral psoralens and long wave ultraviolet light (PUVA) over a two-year period. PUVA was effective in producing a diminution of cutaneous deposits of mycosis fungoides with each clinical pattern of presentation. In most patients complete clearing could not be achieved, and in those considered free of disease, sustained total clearing off PUVA could not be maintained. Lack of response to the effect of PUVA if reinstituted for recurrence of disease did not occur.The palliative use of PUVA for the treatment of mycosis fungoides is recommended.
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  • 4
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Tissue cyst induced Toxoplasma gondii infections were examined in 2 beagle dogs orally inoculated with tissue cysts. Neither dog developed clinical signs of toxoplasmosis. Both dogs developed low antibody titers to T. gondii. The MAT and IFAT were superior to the LAT and IHT tests for detecting antibodies to T. gondii.
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  • 5
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
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  • 6
    ISSN: 1437-1596
    Keywords: Key words Short tandem repeats (STRs) ; Allelic ; ladders ; Mass spectrometry ; DNA fragment analysis ; Microvariants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract DNA separations which traditionally have been performed by slab gel or capillary electrophoresis, may now be conducted via time-of-flight mass spectrometry (TOF-MS). The advantages of using a mass spectrometry approach for short tandem repeat (STR) characterization include a dramatic increase in both the speed of analysis and the accuracy of mass measurements. We report here typing of the STR loci TH01, TPOX, and CSF1PO as well as the sex-typing marker amelogenin using TOF-MS. Allelic ladders, which are typically used with electrophoretic separation systems to correct for mobility differences of DNA fragments under various conditions, are not needed for accurate genotyping with TOF-MS. A mass precision of 0.1% RSD, which corresponds to approximately 0.1 nucleotide, was routinely observed. Mass accuracies were better than a fraction of a single nucleotide when a daily mass calibration was used. STR microvariants, such as the TH01 allele 9.3, could be detected and resolved from alleles which differ by as little as a single base. In addition, the smaller PCR product sizes (55– 125 bp) examined in this study have the potential advantage of being more successful when amplifying forensic samples with degraded DNA.
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  • 7
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Injektion von Shigella Endotoxin (2 mg) in den Glaskörperraum eines normalen Kaninchens führt zu einem Infiltrat von polymorphkernigen Leukozyten, Miosis und zu einer leichten Erweiterung der Gefäße von Iris, Bindehaut und Limbus. Außerdem kommt es zu einem Zusammenbruch der Blut- Kammerwasser- und Blut-Glaskörperschranke. Eine signifikante Menge von löslichem Blutprotein und prostaglandineähnlichem Material (PG) werden in der Vorderkammer- und Glaskörperflüssigkeit gefunden, die nach 24 Stunden abgesaugt wurde. Wurde das Endotoxin in Augen injiziert, die vorher sensorisch denerviert waren, so wurden ähnliche Gefäßveränderungen hervorgerufen, welche offenbar weniger schnell auftreten als in den normalen Augen. Andererseits scheint die Menge von PG-ähnlichem Material in Kammerwasser und Glaskörper höher als in den normalen Augen zu sein. Auch die Fähigkeit von excidierter Iris, PG von exogenen Vorläufern zu produzieren, scheint erhöht. Wenn das PG ein bedeutender Vermittler der Augenveränderungen in der frühen Phase ist, so weisen die Ergebnisse darauf hin, daß dieses entzündliche Gewebshormon in der Ermöglichung der Augenveränderungen weniger wirkungsvoll ist in den Augen, die vorher von funktionalen sensorischen Nerven befreit wurden.
    Notes: Abstract Injection of Shigella endotoxin (2 μg) into the vitreous chamber of a normal rabbit eye induces an infiltration of polymorphonuclear leucocytes, miosis, a moderately intense dilation of iris, conjunctival and limbal vessels, and a breakdown in the blood-aqueous and blood-vitreal barriers. Significant amounts of soluble blood protein and prostaglandin-like (PG) material are found in the aqueous and vitreous humours withdrawn at 24 h. Endotoxin injected into the sensory denervated eye elicits similar vascular changes which appear to occur less rapidly than in normal eyes. Conversely, the levels of aqueous and vitreal PG-like material, as well as the capacity of excised irides to form PG from exogenous precursors, seems greater in the denervated eyes. If PG is an important mediator of ocular changes in the early phases, the results suggest that the action of this inflammatory autacoid in facilitating the ocular changes is less effective in eyes deprived of functional sensory nerves.
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  • 8
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of congenital miosis associated with myopia and cataract is described. Tissue obtained at iridectomy was examined with the electron microscope and compared with a specimen of normal iris. The miotic iris was found to be hypoplastic and to display differences in the cellular density of the stroma. The contractile processes of the dilator myoepithelium were conspicuously absent from the underlying stroma, and the existing myofibrils were much disarranged.
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