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  • 1
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    Charlottesville, Va : University of Virginia Library
    Keywords: Virginia, History, Civil War, 1861-1865.
    ISBN: 0-585-21625-8
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  • 2
    Keywords: Medicine ; Pharmacology ; Biomedicine ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Immunotoxicology: A Brief History -- Clinical Immunotoxicology -- Investigative Immunotoxicology -- Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing -- Markers of Inflammation -- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR) -- Methylated-Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice -- Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment -- Host Resistance Assays -- Enhanced Histopathology Evaluation of Lymphoid Organs -- Tumor Challenges in Immunotoxicity Testing -- Flow Cytometry for the Immunotoxicologist -- Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T Lymphocyte Assay -- Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing -- Natural Killer (NK) Cell Assays in Immunotoxicity Testing -- Dendritic Cell Assays -- Evaluating Macrophages in Immunotoxicity Testing -- Evaluating Cytokines in Immunotoxicity Testing -- Functional Assays of Hematopoietic Stem Cells in Toxicology Research -- CD4+ T Cell Differentiation and Activation -- Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing -- Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay -- Challenges for Integrating Immunotoxicology into the 21st Century Toxicology Testing Paradigm
    Abstract: This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing
    Pages: XIII, 412 p. 41 illus., 23 illus. in color. : online resource.
    Edition: 2nd ed. 2018.
    ISBN: 9781493985494
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  • 3
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: Genomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index
    Abstract: 〈p〉Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.〈/p〉〈p〉℗ 〈/p〉〈p〉This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact. 〈/p〉
    Pages: X, 319 p. 34 illus., 26 illus. in color. : digital.
    ISBN: 9781461446668
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  • 4
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    London : Butterworths
    Call number: QS525:24(4)
    Keywords: Cytodiagnosis / Technique ; Histochemistry / Technique ; Pathology, Cellular / Techniques
    Notes: Rev. ed. of: Handbook of histopathological and histochemical techniques. 3rd ed. 1974.
    Pages: vii, 642 p. : ill.
    Edition: 4th ed.
    ISBN: 0407729038
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    QS525:24(4) available
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  • 5
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    New York, NY : American Association of Pharmaceutical Scientists
    Keywords: Medicine ; Toxicology ; Biochemistry ; Biomedicine ; Biomedicine general ; Pharmacology/Toxicology ; Biochemistry, general ; Springer eBooks
    Pages: : digital
    ISBN: 9781441974150
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  • 6
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    New York : Academic Press
    Call number: QH447:31/Mag
    Keywords: Extracellular Space ; Molecular Biology ; Gene expression / Congresses
    Pages: xli, 833 p. : ill.
    ISBN: 0126483604
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    QH447:31/Mag departmental collection or stack – please contact the library
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  • 7
    Call number: 08-Nukl
    Keywords: Solids / Spectra ; Nuclear magnetic resonance spectroscopy
    Notes: Includes index.
    Pages: xi, 295 p. : ill.
    ISBN: 0122811801
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    08-Nukl departmental collection or stack – please contact the library
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  • 8
    Keywords: Life sciences ; Biomedical Engineering ; Proteins ; Cell Physiology ; Microbiology ; Life sciences ; Protein Science ; Microbiology ; Biological and Medical Physics, Biophysics ; Biomedical Engineering/Biotechnology ; Cell Physiology ; Springer eBooks
    Description / Table of Contents: Chapter 1. Protein folding in the cell – the role of molecular chaperones -- Chapter 2. Structure and function of the Hsp60 Chaperonins -- Chapter 3. Classical View on the Regulation of Heat-shock response -- Chapter 4. Recent Advances in the Regulation of Heat-shock Response- Chapter 5. Multiple Chaperonins in Bacteria -- Chapter 6. Multiple Chaperonins in Mycobacteria -- Chapter 7. Dynamic interplay of the Myxobacterial chaperonins -- Chapter 8. Division of Labour in Rhizobial Chaperonins -- Chapter 9. Cooperativity of archaeal and bacterial chaperonins -- Chapter 10. Evolution of multiple chaperonins
    Abstract: This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins with an introductory chapter on the structural and functional aspects of chaperonins, followed by an outline on different mechanisms of their regulation. Subsequently, the book provides a comprehensive overview on how the multiple-chaperonins have embraced biological requirements in different classes of microbes, discussing their functional diversity, evolutionary paths and the latest advances in the field. It brings together leading experts from across the globe in offering a detailed account of the structural, biochemical, functional and phylogenetic characteristics of microbial chaperonins for students, researchers and teachers working in the area of microbiology/ biophysics/ parasitology – more specifically, in protein folding pathways
    Pages: IX, 170 p. 46 illus., 38 illus. in color. : online resource.
    ISBN: 9789811046513
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  • 9
    Keywords: Medicine ; Oncology ; Toxicology ; Biomedicine ; Cancer Research ; Pharmacology/Toxicology ; Springer eBooks
    Description / Table of Contents: T cell responses in myeloma -- Novel antigenic targets for immunotherapy in myeloma -- Antibody-based therapies in Multiple Myeloma -- Defining multiple myeloma as a target for DNA gene fusion vaccines -- Harnessing allogeneic immunity for anti-myeloma response -- Dendritic cell and peptide-based vaccination in myeloma -- New Proteasome inhibitors -- Newer Imids -- New agents in myeloma -- Early Combination Studies in MM -- The effect of novel antimyeloma agents on bone metabolism -- Index
    Abstract: 〈p〉Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.〈/p〉〈p〉℗ 〈/p〉〈p〉This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact. 〈/p〉
    ISBN: 9781461452607
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  • 10
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    Bristol : Institute of Physics Pub.
    Call number: 08-Nukl
    Keywords: Ultrasonics in medicine
    Notes: "Based on invited lectures presented at the Third Mayneord-Phillips Summer School 1997."
    Pages: xxxi, 314 p. : ill. (some col.)
    ISBN: 0750305932
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