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  • 1
    Publication Date: 2013-02-09
    Description: Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, including leukemias, and result in overproduction of the (R)-enantiomer of 2-hydroxyglutarate [(R)-2HG]. Elucidation of the role of IDH mutations and (R)-2HG in leukemogenesis has been hampered by a lack of appropriate cell-based models. Here, we show that a canonical IDH1 mutant, IDH1 R132H, promotes cytokine independence and blocks differentiation in hematopoietic cells. These effects can be recapitulated by (R)-2HG, but not (S)-2HG, despite the fact that (S)-2HG more potently inhibits enzymes, such as the 5'-methylcytosine hydroxylase TET2, that have previously been linked to the pathogenesis of IDH mutant tumors. We provide evidence that this paradox relates to the ability of (S)-2HG, but not (R)-2HG, to inhibit the EglN prolyl hydroxylases. Additionally, we show that transformation by (R)-2HG is reversible.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836459/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836459/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Losman, Julie-Aurore -- Looper, Ryan E -- Koivunen, Peppi -- Lee, Sungwoo -- Schneider, Rebekka K -- McMahon, Christine -- Cowley, Glenn S -- Root, David E -- Ebert, Benjamin L -- Kaelin, William G Jr -- P30 DK049216/DK/NIDDK NIH HHS/ -- R01 CA068490/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23393090" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics/*metabolism ; Glutarates/*metabolism ; *Hematopoiesis ; Humans ; Isocitrate Dehydrogenase/genetics/*metabolism ; Leukemia/*enzymology/genetics ; Models, Biological ; Procollagen-Proline Dioxygenase/*antagonists & inhibitors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-02-26
    Description: In underdoped cuprate superconductors, a rich competition occurs between superconductivity and charge density wave (CDW) order. Whether rotational symmetry-breaking (nematicity) occurs intrinsically and generically or as a consequence of other orders is under debate. Here, we employ resonant x-ray scattering in stripe-ordered superconductors (La,M)2CuO4 to probe the relationship between electronic nematicity of the Cu 3d orbitals, structure of the (La,M)2O2 layers, and CDW order. We find distinct temperature dependences for the structure of the (La,M)2O2 layers and the electronic nematicity of the CuO2 planes, with only the latter being enhanced by the onset of CDW order. These results identify electronic nematicity as an order parameter that is distinct from a purely structural order parameter in underdoped striped cuprates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Achkar, A J -- Zwiebler, M -- McMahon, Christopher -- He, F -- Sutarto, R -- Djianto, Isaiah -- Hao, Zhihao -- Gingras, Michel J P -- Hucker, M -- Gu, G D -- Revcolevschi, A -- Zhang, H -- Kim, Y-J -- Geck, J -- Hawthorn, D G -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2016 Feb 5;351(6273):576-8. doi: 10.1126/science.aad1824.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. ; Leibniz Institute for Solid State and Materials Research IFW Dresden, Helmholtzstrasse 20, 01069 Dresden, Germany. ; Canadian Light Source, Saskatoon, Saskatchewan, S7N 2V3, Canada. ; Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada. Perimeter Institute for Theoretical Physics, 31 Caroline Street North, Waterloo, Ontario N2L 2Y5, Canada. ; Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, NY 11973, USA. ; Synthese Proprietes et Modelisation des Materiaux (SP2M), UMR 8182, Universite Paris-Sud, 91405 Orsay Cedex, France. ; Department of Physics, University of Toronto, Toronto, Ontario M5S 1A7, Canada. ; Leibniz Institute for Solid State and Materials Research IFW Dresden, Helmholtzstrasse 20, 01069 Dresden, Germany. Paris Lodron University Salzburg, Chemistry and Physics of Materials, Hellbrunner Strasse 34, 5020 Salzburg, Austria. ; Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada. dhawthor@uwaterloo.ca.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912696" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have studied 72 families with at least one child with cystic fibrosis (CF); they were referred because they had requested pre-natal diagnosis in a future pregnancy. The ΔF508 mutation was found in 108/140 CF chromosomes (77%). In 41/72 families (57%), both parents carried a deleted chromosome and the child was doubly deleted. In only 4 families, 2 of them being consanguineous, did neither parent carry a deleted chromosome. Meconium ileus was associated with children who were ΔF508/ΔF508, ΔF508/non-deleted and non-deleted/ non-deleted.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1084
    Keywords: Diffuse liver disease ; MRI ; CT ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-nine patients with diffuse liver disease were examined by ultrasound, CT and MRI. MRI was performed using T1- and T2-weighted spin-echo sequences as well as fast gradient-echo-sequences. The paramagnetic contrast agent Gd-DTPA was applied intravenously (0.1 mmol/kg). in patients with hepatitis, MRI could be used in guiding liver biopsies as inflammatory changes were clearly delineated. CT and ultrasound were superior to MRI in the detection of focal or diffuse fatty degeneration. On the other hand MRI was more helpful in differentiating fatty changes and neoplasm. In liver cirrhosis, fibrotic changes were most clearly demonstrated by MRI. In patients suffering from hemochromatosis MRI offers advantages over CT and ultrasound in the diagnosis and follow up due to the paramagnetic properties of iron, resulting in a reduction in signal intensity. In patients with Wilson's disease a characteristic pattern of parenchymal changes was seen. Administration of Gd- DTPA contributes additional information about perfusion conditions in the liver parenchyma, however this information was not of diagnostic relevance in the cases we studied.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Potential exposure to pesticide residues resulting from burning wood treated with phenoxy and pyridine herbicides was assessed. Wood samples from trees treated with 2,4-D [2,4-dichlorophenoxy acetic acid], dicamba [3,6-dichloro-o-anisic acid], dichlorprop [2-(2,4-dichlorphenoxy) propionic acid], picloram [4-amino-3,5,6-trichloropicolinic acid], and triclopyr (3,5,6-trichloro-2-pyri dinyl)oxy acetic acid contained variable amounts of parent compound residues at 4, 8, and 12 months after application. At the time of the latter sampling, residues of 2,4-D, dicamba, and picloram were 〈2.1 mg/kg on a fresh weight basis. Mean residue concentrations of triclopyr and dichlorprop were somewhat higher at 3.5 and 13.0 mg/kg, respectively. In a laboratory experiment, samples with known amounts of herbicide residue were subjected to either slow or rapidly burning conditions in a tube furnace. During slow combustion, relatively stable compounds such as 2,4-D, dicamba, and dichlorprop were released in significant amounts. Rapid combustion greatly enhanced decomposition of 2,4-D, dicamba, dichlorprop, picloram, and triclopyr. A well-developed fire in a wood stove or fireplace, with active flaming combustion, where temperatures commonly reach 800–l,000°C, should result in greater than 95% thermal decomposition of the herbicides examined in this study. Burning of herbicide-treated wood under smoldering conditions could result in very low levels of herbicide residue in ambient indoor air. However, the exposure levels are less than 0.3% of the threshold limit value for 2,4-D and triclopyr. The exposure is also more than 3 orders of magnitude lower than the established acceptable daily intakes for these products.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 50 (1894), S. 499-499 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] OWING to my absence from home, I have only just seen the letters of the Rev. E. Hill, M.M.S., and James Heelis, in NATURE of August 2 and 9, on the above subject. The writers have apparently overlooked the very interesting report by Profs. Rücker and Thorpe, published in the Brit. Assoc. Report ...
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  • 7
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the effect of mismatch between the reflectivity resonance and the gain spectra of vertical cavity surface emitting lasers. Detuning was caused by hydrostatic pressure and self-heating. Hydrostatic pressure shifts the gain peak towards shorter wavelengths with respect to the Fabry-Pérot (FP) resonance without modifying the gain spectrum. The threshold current remained unchanged for a positive mismatch of up to 18 nm. It increased four-fold for a negative mismatch of −13 nm at 0.5 GPa, where lasing disappeared. Increased threshold current and quenching of the emission are a consequence of the decrease of the gain at the FP resonance. A similar effect was observed when the gain peak was red-shifted with respect to the FP resonance by increasing the injected power. Increased mismatch is accompanied by a decrease of the gain at the emission wavelength which is responsible for the laser output quenching at high injected powers. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 439 (2006), S. 392-392 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir Your News Story “Animal-rights group sues over ‘disturbing’ work on sea lions” (Nature 436, 315; 200510.1038/436315a) shows how wildlife researchers face escalating criticism over their ...
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 11 (1974), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The Stoics expressed great concern about emotion related psychophysiological phenomena as pathological states of body and spirit. They outlined procedures through which all bodily functions could be brought under voluntary control. The Pneumatist School of Medicine of the first century A.D. adopted these philosophical convictions and instituted them in their diagnostic and treatment techniques for psychosomatic disorders. Pneumatic theory, and its application in this context, is described.〈blockFixed type="quotation"〉How easy it is to repel and to wipe away every impression which is troublesome or unsuitable, and immediately to be in all tranquility…. Nature has not so mingled the intelligence with the composition of the body, as not to have allowed thee the power of circumscribing thyself and of bringing under submission to thyself all that is thy own.Marcus Aurelius
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  • 10
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Severe factor IX deficiency is an X-linked disorder which gives rise to spontaneous and often life-threatening bleeds. The major source of morbidity worldwide is recurrent haemarthroses, giving rise to joint destruction and deformity. However, the incidence of spontaneous haemarthroses has decreased since the advent of prophylactic home-based, on-demand, early replacement therapy.We present the case of a non-ambulant, 13-year-old boy from Chernobyl, who did not have access to this type of treatment, and whose deformity was managed using the Ilizarov external fixator.An external fixator was applied under general anaesthetic in theatre. Haemostasis was achieved by maintaining his FIX levels at 1.0 IU mL−1 pre- and post-operatively. Three months later, the fixed flexion deformity had been reduced from 50 to 5°. Four months postsurgery, this boy was walking freely without pain. There was no peri- or post-operative bleeding or joint swelling.
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