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  • 1
    Publication Date: 2013-05-03
    Description: We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and approximately 25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704730/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704730/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cancer Genome Atlas Research Network -- Kandoth, Cyriac -- Schultz, Nikolaus -- Cherniack, Andrew D -- Akbani, Rehan -- Liu, Yuexin -- Shen, Hui -- Robertson, A Gordon -- Pashtan, Itai -- Shen, Ronglai -- Benz, Christopher C -- Yau, Christina -- Laird, Peter W -- Ding, Li -- Zhang, Wei -- Mills, Gordon B -- Kucherlapati, Raju -- Mardis, Elaine R -- Levine, Douglas A -- 5U24CA143799-04/CA/NCI NIH HHS/ -- 5U24CA143835-04/CA/NCI NIH HHS/ -- 5U24CA143840-04/CA/NCI NIH HHS/ -- 5U24CA143843-04/CA/NCI NIH HHS/ -- 5U24CA143845-04/CA/NCI NIH HHS/ -- 5U24CA143848-04/CA/NCI NIH HHS/ -- 5U24CA143858-04/CA/NCI NIH HHS/ -- 5U24CA143866-04/CA/NCI NIH HHS/ -- 5U24CA143867-04/CA/NCI NIH HHS/ -- 5U24CA143882-04/CA/NCI NIH HHS/ -- 5U24CA143883-04/CA/NCI NIH HHS/ -- 5U24CA144025-04/CA/NCI NIH HHS/ -- P30 CA008748/CA/NCI NIH HHS/ -- P30 CA016086/CA/NCI NIH HHS/ -- P30 CA016672/CA/NCI NIH HHS/ -- P50 CA098258/CA/NCI NIH HHS/ -- U24 CA143799/CA/NCI NIH HHS/ -- U24 CA143835/CA/NCI NIH HHS/ -- U24 CA143840/CA/NCI NIH HHS/ -- U24 CA143843/CA/NCI NIH HHS/ -- U24 CA143845/CA/NCI NIH HHS/ -- U24 CA143848/CA/NCI NIH HHS/ -- U24 CA143858/CA/NCI NIH HHS/ -- U24 CA143866/CA/NCI NIH HHS/ -- U24 CA143867/CA/NCI NIH HHS/ -- U24 CA143882/CA/NCI NIH HHS/ -- U24 CA143883/CA/NCI NIH HHS/ -- U24 CA144025/CA/NCI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- U54 HG003079/HG/NHGRI NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- U54HG003067-11/HG/NHGRI NIH HHS/ -- U54HG003079-10/HG/NHGRI NIH HHS/ -- U54HG003273-10/HG/NHGRI NIH HHS/ -- England -- Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23636398" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/genetics ; Chromosome Aberrations ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA Polymerase II/genetics ; DNA-Binding Proteins/genetics ; Endometrial Neoplasms/*classification/*genetics ; Exome/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Genome, Human/*genetics ; Genomics ; Humans ; Ovarian Neoplasms/genetics ; Signal Transduction ; Transcription Factors/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Two species of the family Bothidae (lefteye flounders), Mancopsetta maculata metadata and M. milfordi occur in the south-west Atlantic but are caught rarely by commercial bottom trawlers. Little is therefore known about their general biology from this area. A total of 251 M. maculata and 276 M. milfordi were sampled during deep-water exploratory fishing conducted in November 1994 within the Falkland Islands Interim and Outer Conservation Zones, at depths of 400-1000 m, using standard commercial bottom trawling gear. The two species were found to have similar geographical distributions between 48.30′-53.30'S and 55°-62° W and were often obtained at the same stations in depths of 400-900 m on the continental slope. Mancopsetta maculata maculata showed a uni-modal cohort structure with a modal length at the 29-cm total length size-class. Males of M. m. maculata outnumbered females in a ratio of 3.5 : 1. Mancopsetta milfordi showed a tri-modal length distribution, the main mode at the 37-cm total length size-class, with females outnumbering males in a ratio of 1.1 : 1. Length-weight relationships and length-at-age information are presented for the two species. Diet was determined from the analysis of stomach contents and, although the major prey type for both species consisted of crustaceans, the morid fish Austrophycis marginata also formed an important part of the diet of M. milfordi. Key words: Mancopsetta maculata maculata; Mancopsetta milfordi; distribution; south-west Atlantic; size; diet.
    Type of Medium: Electronic Resource
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