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Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

Grever MR ; Abdel-Wahab O ; Andritsos LA ; [et al.]

Blood 129 (5), 553-560

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Abstract: Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. As more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease. The development of internationally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinical trials to provide optimal care. Despite the success achieved in managing these patients, continued participation in available clinical trials both in the front-line and particularly in the relapse setting is highly recommended. The Hairy Cell Leukemia Foundation convened an international conference to provide common definitions and structure to guide current management. There is substantial opportunity for continued research in this disease. In addition to the importance of optimizing the prevention and management of the serious risk of infection, organized evaluations of minimal residual disease and treatment at relapse offer ample opportunities for clinical research. Finally, a scholarly evaluation of quality of life in the increasing number of survivors of this now manageable, chronic illness merits further study. The development of consensus guidelines for this disease offers a framework for continued enhancement of the outcome for patients.

Type of Publication: Journal article published

PubMed ID: 27903528

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=75862

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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt SI ; Camp NJ ; Skibola CF ; [et al.]

Nature Communications 7 (), 10933-

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Abstract: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P〈5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Type of Publication: Journal article published

PubMed ID: 26956414

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=69561

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