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  • 1
    Call number: YY Diss Cao/Mag
    Keywords: DKFZ-publications / academic dissertations
    Notes: Thesis (PhD) -- Technische Universität, Dresden, 2010.
    Pages: 112 p.
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  • 2
    Keywords: Medicine ; Neurosciences ; Alternative Medicine ; Acupuncture ; Neurobiology ; Medicine & Public Health ; Acupuncture ; Neurobiology ; Complementary & Alternative Medicine ; Neurosciences ; Springer eBooks
    Pages: : digital
    ISBN: 9783642108570
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  • 3
    Keywords: Biochemistry ; Pharmaceutical technology ; Protein Science ; Pharmaceutical Sciences/Technology ; Protein Structure ; Springer eBooks
    Description / Table of Contents: 1. Cell adhesion molecules and development -- 2. Receptors and signal transduction -- 3. Single-transmembrane proteins and antibody drugs -- 4. Viral membrane proteins -- 5. Biosynthesis and folding of oily peptide chains -- 6. Quality control in producing membrane proteins
    Abstract: This book reviews recent advances regarding the biochemical and biophysical properties of membrane proteins and their applications in biomedicine. Divided into two thematic parts, this second volume addresses proteins’ formation, signaling and malfunctions. It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and discusses their structures, functions, related diseases, and roles in drug discovery in detail. In turn, the book elucidates the lifecycle of membrane proteins, including their synthesis and facilitated folding process, as well as QC procedures for their production. Additional topics include fundamental concepts, the latest findings, and critical puzzles yet to be solved. Given its scope, the book will appeal to a broad readership in the field of membrane structural and functional biology. Junior scientists can use it as an introduction to the field, while advanced scientists will find a broader view of the field beyond their area of specialization
    Pages: VII, 130 p. 28 illus., 26 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811390777
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  • 4
    Keywords: Plant genetics ; Plant breeding ; Agriculture ; Plant Genetics and Genomics ; Plant Breeding/Biotechnology ; Agriculture ; Springer eBooks
    Description / Table of Contents: Importance of duckweeds in basic research and its industrial applications -- Background history of the international Spirodela genome sequencing initiatives -- Cytogenetics and karyotype evolution of duckweeds -- Duckweed organelle genomes -- Repetitive sequences: Impacts and uses in the Spirodela genome -- Genotyping by sequencing of duckweeds -- Genome and transcriptome of Landoltia punctata -- Transcriptome responses of Spirodela polyrhiza -- Strategies & tools for sequencing duckweeds -- Transformation development in duckweeds
    Abstract: This book tells the story behind the first Spirodela genome sequencing project. Further, it describes the current genomics applications of these findings, and efforts to sequence new genomes within the family. The closing chapters address the sequencing of the over 1 Gigabase Wolffia genomes, which could have major impacts on genome evolution and agricultural research. The duckweed or Lemnaceae family is a collection of 5 genera and 37 species of the smallest, fastest-growing flowering plants. Many of these aquatic monocotyledonous plants can grow all over the world, in a variety of climates. Given their simplified and neotenous morphology, duckweeds have been researched for several decades as a model species for plant physiology and ecotoxicological research, contributing to our understanding e.g. of flowering response, plant circadian systems, sulfur assimilation pathways and auxin biosynthesis. In addition, duckweed-based treatment has been a favorite and feasible means, especially in developing countries, of removing phosphorus and pharmaceutical chemicals from sewage and wastewater. With a dry annual mass yield per hectare of up to 80 tonnes (equivalent to 10 tonnes of protein), duckweed is also a promising aquatic crop in new modern and sustainable agriculture. Besides being an excellent primary or supplemental feedstock for the production of livestock and fish, duckweed biomass can be utilized as a potential resource for human nutrition, biofuel, or bioplastics, depending on water quality as well as protein or starch accumulating procedures. These academic and commercial interests have led to international efforts to sequence the Spirodela polyrhiza genome, the smallest and most ancient genome in the family
    Pages: XVIII, 185 p. 30 illus., 21 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030110451
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  • 5
    Keywords: Medicine ; Cancer Research ; Biomedicine ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Basic Histopathological Methods and Breast Lesion Types for Research.-℗ Clinical Applications for Immunohistochemistry of Breast Lesions.-℗ Immunohistochemistry for Triple-Negative Breast Cancer.-℗ In Situ Hybridization of Breast Cancer Markers.-℗ ℗ ℗ ℗ Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).-℗ Quantification of mRNA Levels Using Real-Time Polymerase Chain Reaction (PCR).-℗ Detection of MiRNA in Cultured Cells or Xenograft Tissues of Breast Cancer.-℗ Pyrosequencin g Analysis for Breast Cancer DNA Methylome.-℗ Vita-Assay ́„Ø Method of Enrichment and Identification of Circulating Cancer Cells/Circulating Tumor Cells (CTCs).-℗ Breast Cancer Stem Cell Isolation.-℗ Cellular Apoptosis Assay of Breast Cancer -- Assessment of Matrix Metalloproteinases by Gel Zymography.-℗ Assessment of Synthetic Matrix Metalloproteinase Inhibitors by Fluorogenic Substrate Assay.-℗ Determination of Breast Cancer Cell Migratory Ability.-℗ A Novel Collagen Dot Assay for Monitoring Cancer Cell Migration.-℗ Three-Dimensional Assay for Studying Breast Cancer Cell Invasion.-℗ A Combined Phagocytosis and Fluorescent Substrate Degradation Assay to Simultaneously Assess Cell Migration and Substrate Degradation.-℗ Analysis of Invadopodia Formation in Breast Cancer Cells.-℗ Patient-Derived Tumor Xenograft Models of Breast Cancer.-℗ Monitoring Phosphatidic Acid Signaling in Breast Cancer Cells Using Genetically Encoded Biosensors -- 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method.-℗ Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model.-℗ Pharmacokinetics and Pharmacodynamics in Breast Cancer Animal Models.-℗ Intracellular Delivery of Fluorescently Labeled Polysaccharide Nanoparticles to Cultured Breast Cancer Cells.-℗ Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression
    Abstract: This volume provides resources, ideas, and bench manuals for the study of breast cancer. This book is divided into five sections: methods used in clinical laboratory for diagnosis (Detection of Molecular Markers of Breast Cancer); methods used in both clinical and research laboratories for testing genetic alterations (Genetic Detection of Breast Cancer) and (Isolation of Breast Cancer Cells); methods used to study the behavior of breast cancer cells (In Vitro Experimental Assays for Breast Cancer); and methods used for mimicking human breast cancer in a living organism (In Vivo Experimental Models for Breast Cancer).℗ Breast Cancer: Methods and Protocols℗ also explores several recently developed techniques for the study of breast cancer progression. Written in the highly successful℗ Methods in Molecular Biology℗ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough,℗ Breast℗ Cancer: Methods and Protocols,℗ is a valuable handbook for both graduate and advanced undergraduate students of biological sciences, as well as scientists, technicians, and physicians working in the academic, hospital, or pharmaceutical industry aimed at studying or diagnosing breast cancer
    Pages: XII, 332 p. 71 illus., 13 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9781493934447
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  • 6
    Keywords: Life sciences ; Pharmaceutical technology ; Proteins ; Life sciences ; Protein Science ; Pharmaceutical Sciences/Technology ; Protein Structure ; Springer eBooks
    Description / Table of Contents: Chapter 1: Membrane Proteins as Critical Molecules -- Chapter 2: Channels -- Chapter 3: Solute Transporters. Chapter 4. Cytoplasmic Membrane Proteins -- Chapter 5: Nuclear Membrane Proteins: the transportation of genetic materials -- Chapter 6. Membrane Embedded Enzymes and Hydrophobic bio-catalysis
    Abstract: The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. The first volume focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization
    Pages: V, 181 p. 63 illus., 61 illus. in color. : online resource.
    ISBN: 9789811305320
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  • 7
    New York : Cambridge University Press
    Call number: 09-NW:493
    Keywords: Quantum field theory / Congresses
    Pages: xix, 399 p. : ill.
    ISBN: 0521631521
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    09-NW:493 departmental collection or stack – please contact the library
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  • 8
    Cambridge : Cambridge University Press
    Call number: 09-NW:498
    Keywords: Unified field theories
    Notes: Repr. with corrections.
    Pages: xx , 434 p.
    ISBN: 0521634202
    Signatur Availability
    09-NW:498 departmental collection or stack – please contact the library
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  • 9
    Abstract: The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA (1) . Increasing evidence now suggests that sperm small non-coding RNAs (sncRNAs) can mediate intergenerational transmission of paternally acquired phenotypes, including mental stress(2,3) and metabolic disorders(4-6). How sperm sncRNAs encode paternal information remains unclear, but the mechanism may involve RNA modifications. Here we show that deletion of a mouse tRNA methyltransferase, DNMT2, abolished sperm sncRNA-mediated transmission of high-fat-diet-induced metabolic disorders to offspring. Dnmt2 deletion prevented the elevation of RNA modifications (m(5)C, m(2)G) in sperm 30-40 nt RNA fractions that are induced by a high-fat diet. Also, Dnmt2 deletion altered the sperm small RNA expression profile, including levels of tRNA-derived small RNAs and rRNA-derived small RNAs, which might be essential in composing a sperm RNA 'coding signature' that is needed for paternal epigenetic memory. Finally, we show that Dnmt2-mediated m(5)C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information.
    Type of Publication: Journal article published
    PubMed ID: 29695786
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  • 10
    ISSN: 1434-6079
    Keywords: PACS. 42.50.Ct Quantum description of interaction of light and matter; related experiments – 42.50.Lc Quantum fluctuations, quantum noise, and quantum jumps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The spontaneous emission of an excited atom is analyzed by quantum stochastic trajectory approach without both rotating-wave approximation and Markovian approximation. The atom finite size effect is also taken into account. We show by an example that the correction due to the counter-rotating wave term is rather small, even for the largest atomic number of real nuclei.
    Type of Medium: Electronic Resource
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