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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Süddeutscher Kongress für Kinder- und Jugendmedizin; 64. Jahrestagung der Süddeutschen Gesellschaft für Kinder- und Jugendmedizin gemeinsam mit der Süddeutschen Gesellschaft für Kinderchirurgie und dem Berufsverband der Kinder- und Jugendärzte e.V. - Landesverband Bayern; 20150508-20150509; Nürnberg; DOC15sgkjP14 /20150325/
    Publication Date: 2015-03-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: COMBINATION ; MODEL ; MODELS ; FOLLOW-UP ; INFORMATION ; DISEASE ; DISEASES ; RISK ; HEART ; TIME ; MARKER ; ASSOCIATION ; ASSAY ; DESIGN ; PLASMA ; NUMBER ; AGE ; meta-analysis ; smoking ; DATABASE ; C-REACTIVE PROTEIN ; MYOCARDIAL-INFARCTION ; HEART-DISEASE ; vascular disease ; REGRESSION ; ASSOCIATIONS ; ISCHEMIC-STROKE ; CORONARY-HEART-DISEASE ; METAANALYSIS ; LEVEL ; methods ; EXTENT ; ARTERY-DISEASE ; MIDDLE-AGED MEN ; ACTIVATING-FACTOR-ACETYLHYDROLASE ; ATHEROSCLEROSIS RISK ; lipoprotein-associated phospholipase A(2) ; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE-A2 ; REPEAT
    Abstract: Background A large number of observational epidemiological studies have reported generally positive associations' between circulating mass and activity levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA(2) markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors. Objectives By combination of data from individual participants from all relevant observational studies in a systematic,meta-analysis, with correction for regression dilution (using available data on serial measurements of Lp-PLA(2)), the Lp-PLA(2) Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA(2) with coronary heart disease (and, where data are sufficient with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA(2) and cardiovascular outcomes. Methods A central database is being established containing data on circulating Lp-PLA(2) values, sex and other potential confounding factors, age at baseline Lp-PLA(2) Measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA2 and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA(2) will yield information on a total of about 15 000 cardiovascular disease endpoints
    Type of Publication: Journal article published
    PubMed ID: 17301621
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  • 3
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Mit Hilfe der Röntgenbeugung wurde die Kristallstruktur von Poly-Epichlorhydrin ermittelt. Die Gitterkonstanten der orthorhombischen Elementarzelle sind: a = 12,16 Å, b = 4,90 Å und c = 7,03 Å. Die Werte sind in übereinstimmung mit den von RICHARDS (Diss. Abstr. 22 (1961) 1029) angegebenen. Es werden zwei Raumgruppen, nämlich Pna21 und Pnam vorgeschlagen, wobei eine größere Wahrscheinlichkeit für die erstere spricht Die Kettenkonformation entspricht genau der von den Autoren schon früher für das Poly-Epichlorhydrin angegebenen. Die Chlormethyl-Seitengruppen liegen in einer zur Kettenachse senkrechten Ebene, wie es dem Prinzip der „staggered bonds“ entspricht
    Notes: The crystal structure of poly(chloromethyl ethylene oxide) or polyepichlorohydrin has been carried out, by X-ray diffraction technique. The parameters of the orthorhombic unit-cell are: a = 12.16 Å, b = 4.90 Å, c = 7.03 Å, fairly coincident with those given by RICHARDS (Diss. Abstr. 22 (1961) 1029). Two space-groups are proposed: Pna21 and Pnam, the former being more probable. Chain conformation is exactly like that previously given by the authors for the poly-propylene-oxide. The side chloromethyl-group lies on a plane perpendicular to the chain axis, in accordance with the staggered bonds principle.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 94 (1966), S. 194-204 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es werden die Ergebnisse einer Untersuchung der Kristallstruktur von Polypropylenoxid mitgeteilt. In dem hier vorgeschlagenen Modell weichen die Ketten in ihrer Lage nur um einen Winkel von 15° um die C—O-Bindung von der vollständig ebenen Anordnung ab.Dieses Modell ergibt, verglichen mit dem von STANLEY and LITT angegebenen, eine merklich bessere Übereinstimmung der Werte von Fo und Fc und leichter zu rechtfertigende Atomabstände innerhalb der einzelnen Kette.
    Notes: The results of a detailed investigation on the crystal structure of poly(propylene oxide) are reported. The chain model here proposed differs from the full-planar one only by a deviation of 15° around the C—O bonds.This model is accounted for by both the sensibly better agreement between Fo and Fc and the more justifiable intra-chain contacts with respect to those observed for the model previously studied by STANLEY and LITT, with which it is compared.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 157 (1972), S. 269-278 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Mit Hilfe der Röntgenbeugung wurde die Kristallstruktur von Polypivalolacton ermittelt. Die Gitterkonstanten der monoklinen Elementarzelle sind : a = 9,05, b = 11,58, c = 6,03 Å; (Faserachse), β = 121,5°. Die Raumgruppe ist P21/b. CARAZZOLO hat in einer früheren Arbeit neben einem statistischen Auftreten von enantiomorphen Makromolekülen auf Grund einer groben Näherung ein (T2G2)2-Kettenmodell vorgeschlagen, wobei eine Abweichung von ungefähr 12° im Vergleich zu der trans- und der gauche-Kettenformation vorliegt.Obwohl die (T2G2)2- Kettenkonformation bestätigt worden ist, besitzt das Modell keine Abweichung, mit Ausnahme der —CO—O—, —CH2—C(CH3)2- Bindungen, die eine Verdrehung von 16° bzw. 19° aufweisen. Das statistische Auftreten enantiomorpher Makromoleküle kann ausgeschlossen werden.Die Einzelheiten der Struktur werden diskutiert und mit der älnlichen Konformation der Kristallstruktur des Polyäthylenadipats verglichen.Die Stabilisierungsmöglichkeit der (T2G2)2-Konformation durch eine intramolekulare vorzungsrichtung der C=O-Dipole wird vorgeschlagen.
    Notes: A detailed investigation on the crystal structure of polypivalolactone (PPL) has been performed by X-ray diffraction technique. The dimensions of the monoclinic unit cell are : a = 9.05, b = 11.58, c = 6.03 Å; (fibre axis), β = 121.5°. The space group is P21/b. In a previous work CARAZZOLO proposed, on the basis of a rough approach, a (T2G2)2 chain model with a distortion of about 12° from all trans and gauche conformations, in addition to a statistical occurrence of enantiomorphous macromolecules in the crystal.Although the (T2G2)2 conformation type has been confirmed, the model is not isodistorted, the distortion beeing related only to the —CO—O— and —CH2—C(CH3)2— bonds (16 and 19° respectively); in addition it is possible to exclude the statistical variance previously proposed.The details of the conformation are discussed and compared with similar features of the crystal structure of poly(ethylene adipate).A stabilization of this conformation by a preferred intramolecular arrangement of the main dipoles C=O is suggested.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 83 (1965), S. 196-206 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: In der vorliegenden Arbeit wird über die Kristallstruktur von Polytetrahydrofuran berichtet. Die Gitterkonstanten der monoklinen Elementarzelle sind a = 5,61 ± 0,04 Å, b = 8,92 ± 0,05 Å, c = 12,25 ± 0,10 Å, (Faserachse) und β = 134°30′; die Raumgruppe ist C 2/c.Die Struktur ist durch eine ebene, aber nicht vollständig lineare zick-zack-Kettenkonformation charakterisiert. Zwei Modelle, bei welchen verschiedene Valenzwinkel versuchsweise vergrößert wurden, werden diskutiert. Da bei beiden die Übereinstimmung zwischen den beobachteten und den berechneten Werten der Strukturfaktoren gleich gut ist, konnte keinem der Vorzug größerer Wahrscheinlichkeit gegeben werden.
    Notes: The results of a detailed investigation on the crystal structure of poly-tetrahydrofuran are reported. The unit-cell has a monoclinic symmetry, with a = 5.61 ± 0.04 Å, b = 8.92 ± 0.05 Å, c = 12.25 ± 0.10 Å (fiber axis), and β = 134°30′; space-group C 2/c.It was concluded for a planar zig-zag, but not full linear, chain conformation. Two models arising from an enlargement of different bond angles are proposed and discussed. No definitive choice has been drawn, owing to the same agreement factor between observed and calculated data obtained for both models.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The morphology of poly(ether esteramide)s (PEEA) of the general formula [(6NT6)k-PTMO]z has been investigated by wide and small angle X-ray scattering and electron microscopy techniques. The copolymers are based on poly(esteramide) “hard” segments (containing an average number k of 6NT6 consecutive units) alternating poly(tetramethylene oxide) (PTMO) “soft” segments of constant length (MW ∼ 900). The fraction of crystallized 6NT6 increasing by increasing the PTMO content (i.e., by lowering k), approaching unity for k → 1. The morphology is of lamellar type, with both thickness and width of the crystalline domains (6NT6) decreasing with the increase of PTMO content; in the interlamellar amorphous regions both “soft” and “hard” segments tend to segregate in separate domains. For k ≃ 1, crystalline domains, formed essentially by isolated 6NT6 units, alternate with amorphous PTMO interlayers. The mechanism of evolution of the morphological structure as a function of the copolymer composition is discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The morphology of poly(ether ester)s (PEES) of the general formula [(4GT)k-PTMO]z has been investigated by wide and small angle X-ray scattering and electron microscopy techniques. The copolymers are based on poly(tetramethylene terephthalate) (4GT) “hard” segments (containing an average number k of consecutive 4GT units) alternating poly(tetramethylene oxide) (PTMO) “soft” segments of constant length (MW ∼ 900). The fraction of crystallized 4GT slightly increases by increasing the weight fraction of PTMO up to ca. 0.5; then it rapidly decreases so that an amorphous material is obtained for a PTMO weight fraction of 0.76. PEES display a lamellar-type morphology in which lamellar domains of crystalline 4GT alternate with slightly heterogeneous interlamellar amorphous regions containing both 4GT and PTMO. For high contents of PTMO these domains evolve toward amorphous domains formed by short 4GT segments (k = 2, 3). PEES and the structurally related poly(ether esteramide)s are compared in terms of their morphological structure.
    Additional Material: 7 Ill.
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  • 9
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1211
    Keywords: Key words Human ; B lymphocytes ; Gene regulation ; MHC ; mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Regulation of HLA-DQ gene transcription is a complex phenomenon because the allelic polymorphism associated with these genes and their promoters is a putative source of differential allele expression. Both transcriptional and post-transcriptional regulation could account for the density of the molecules expressed at the cell surface and then for the specificity of the immune response. Different methods have been developed to evaluate the functional consequences of this polymorphism, but at present no universal method allows measurement of either the steady-state level or the half-life time of mRNA species of both DQA1 and DQB1 polymorphic genes in heterozygous cell lines. Here, we propose a potent method, based on relative quantification of reverse transcriptase-polymerase chain reaction products, which analyzes the differential expression of all DQA1 or DQB1 allele combinations. This method is used to analyze the differential expression of HLA-DQB1*0201/0402 alleles in the human heterozygous lymphoblastoid B-cell line. Nucleotidic sequences of the proximal upstream regulatory region of these alleles exhibit significant differences. We show that the DQB1*0402 promoter is able to mediate a transcription strength twice as efficiently as *0201. In addition, the *0402 mRNA steady-state level is also governed by a remarkable post-transcriptional regulation. Indeed, an important part (20%) of the *0402 primary transcript is derived by alternative splicing in a short mRNA translated into a nonfunctional protein. Despite their variable sequence and length, no difference in the half-life of DQB1*0201 and both DQB*0402 mRNAs was observed in B-lymphoblastoid cells. The implications of these findings are discussed.
    Type of Medium: Electronic Resource
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