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  • 1
    Keywords: Neurosciences ; Biological models ; Neurosciences ; Systems Biology ; Springer eBooks
    Description / Table of Contents: Neuronal bases of systemic organization of behavior -- Neural circuits mediating fear learning and extinction -- The hippocampal ensemble code for spatial navigation and episodic memory -- Context-dependent adjustments in executive control of goal-directed behaviour: Contribution of frontal brain areas to conflict-induced behavioural adjustments in primates -- Synaptic excitatory-inhibitory balance underlying efficient neural coding -- Mapping molecular datasets back to the brain regions they are extracted from: Remembering the native countries of hypothalamic expatriates and refugees -- Genome-Scale Brain Metabolic Networks as Scaffolds for the Systems Biology of Neurodegenerative Diseases: Mapping Metabolic Alterations -- Synaptic Plasticity and Synchrony in the Anterior Cingulate Cortex Circuitry: A Neural Network Approach to Causality of Chronic Visceral Pain and Associated Cognitive Deficits -- Large de novo microdeletion in epilepsy with intellectual and developmental disabilities, with a systems biology analysis -- Using Systems Biology and Mathematical Modeling Approaches in the Discovery of Therapeutic Targets for Spinal Muscular Atrophy -- Not Cure but Heal: Music and Medicine
    Abstract: This edition of Advances in Neurobiology brings together experts in the emerging field of Systems Neuroscience to present an overview of this area of research. Topics covered include: how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and diseases with Systems Neuroscience. A hierarchy of biological complexity arises from the genome, transcriptome, proteome, organelles, cells, synapses, circuits, brain regions, the whole brain, and behaviour. The best way to study the brain, the most complex organ in the body composed of 100 billion cells with trillions of interconnections, is with a Systems Biology approach. Systems biology is an inter-disciplinary field that focuses on complex interactions within biological systems to reveal 'emergent properties' - properties of cells and groups of cells functioning as a system whose actual and theoretical description is only possible using Systems Biology techniques
    Pages: XII, 307 p. 51 illus., 32 illus. in color. : online resource.
    ISBN: 9783319945934
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  • 2
    Unknown
    Berlin : Springer
    Call number: E170:27
    Keywords: Neuroblastoma ; Child
    Pages: xv, 298 p. : ill.
    ISBN: 354040841X
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    E170:27 departmental collection or stack – please contact the library
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  • 3
    Keywords: Life sciences ; Proteins ; Life sciences ; Protein Science ; Springer eBooks
    Description / Table of Contents: A Brief Overview of Progranulin in Health and Disease -- Chromatographic Methods for the Purification of Granulin Peptides -- Methods for Expression and Purification of Biologically Active Recombinant Progranulin -- Large-Scale Generation of Recombinant Granulin Peptides in E. coli -- Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine Bridging -- Data Mining: Applying the AD&FTD Mutation Database to Progranulin -- Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases -- Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker -- Analysis of Progranulin-Mediated Akt and MAPK Activation -- Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer Models -- Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features -- Methods to Study the Role of Progranulin in the Tumor Microenvironment -- Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegans -- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response -- Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function -- Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice -- Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the Brain -- The Interaction between Progranulin with Sortilin and the Lysosome -- Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo Development -- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory Arthritis -- Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro Studies -- Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models
    Abstract: This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.”
    Pages: XIII, 363 p. 79 illus., 56 illus. in color. : online resource.
    ISBN: 9781493985593
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  • 4
    Call number: C060:233
    Keywords: Drugs / Dose-response relationship ; Clinical Trials ; Clinical Trials, Phase I as Topic ; Dose-Response Relationship, Drug ; Biostatistics / methods ; Maximum Tolerated Dose
    Description / Table of Contents: Dose finding in clinical trials -- The continual reassessment method -- One-parameter dose toxicity models -- Theoretical properties -- Empirical properties -- Specifications of a CRM design -- Initial guesses of toxicity probabilities -- Least informative normal prior -- Initial design -- The time-to-event CRM -- CRM with multiparameter models -- When the CRM fails -- Stochastic approximation
    Pages: xv, 189 p. : ill.
    ISBN: 9781420091519
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    C060:233 departmental collection or stack – please contact the library
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0738
    Keywords: Key words Calmodulin ; Cadmium ; Lead ; Heavy metal toxicity ; Smooth muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The effect of Cd2+ on myosin light chain kinase (MLCK) reported in the literature is controversial, apparently because the level of Ca2+ contaminating the reaction mixture could not be accurately controlled by the addition of a metal chelator when Cd2+ was also present. In the present study, we have reduced the contaminating Ca2+ to a trace level that did not interfere with the enzyme activity; thus the use of a metal chelator was not necessary. We showed that Cd2+, or Pb2+ had a biphasic effect on MLCK isolated from chicken gizzard: stimulation at low and inhibition at high concentrations. (The stimulatory effect of on the enzyme activity isolated from chicken gizzard: stimulation at low and inhibition at high concentrations). The stimulatory effect of Cd2+ or Pb2+ on MLCK activity was not seen in the absence of calmodulin, and was abolished by trifluoperazine, a calmodulin antagonist, indicating that the heavy metals exert their activation via calmodulin. The inhibition of the enzyme activity by Cd2+ or Pb2+ at higher concentrations was also seen with the calmodulin-independent catalytic fragment of MLCK, suggesting that the inhibition is probably through their binding to sulfhydryl groups that are essential for catalytic activity. Pb2+ was more effective than Cd2+ in stimulating the enzyme activity, but less potent in inhibition. The extent of stimulation by heavy metals most likely resulted from a combination of the biphasic effects. Dithiothreitol and N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine selectively chelated Cd2+ and Pb2+ over Ca2+, and reversed their stimulatory or inhibitory effect on MLCK. Thus, they are useful agents to discriminate between the action of Ca2+ from that of these heavy metal cations. Cd2+ and Pb2+ not only activited MLCK in vitro, but also triggered smooth muscle contraction in an isolated rabbit aortic strip.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1600-5775
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A highly compact and rapid-count-rate multi-element solid-state detector has been designed, built and recently commissioned on the oldest XAFS station of the SRS, station 7.1, which has undergone major refurbishment. The low profile of the detector has been achieved by using the monolithic solution where nine elements with a combined active area of 370 mm2 have been fabricated on Ge of diameter 21.8 mm. A typical energy resolution of 170 eV with a semi-Gaussian shaping time of 0.5 µs has been achieved with X-rays of energy 5.9 keV. The low profile of the detector makes it ideal for several synchrotron radiation applications as it can be easily incorporated into complicated experimental set-ups. These include XAFS of single crystals and samples generated in a stopped flow system, protein crystallography (fluorescence XAFS for MAD or for on-line monitoring), microprobe fluorescence imaging and trace-element analysis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Three-dimensional information is obtained for the Cu site in azurin at very high resolution by combining high-resolution crystallographic structures and EXAFS data for the oxidized and reduced form of the protein. This combined approach has allowed us to define the subtle structural changes (〈0.1 Å) which take place at the Cu site during a single-electron redox process.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare blood mercury concentrations of infertile couples with those of fertile couples in Hong Kong, and to examine the relationship between blood mercury concentrations and seafood consumption.Design Case–control study.Setting In vitro fertilisation (IVF) Unit and Antenatal Unit of a university teaching hospital.Sample One hundred fifty-seven infertile couples attending IVF treatment and 26 fertile couples attending antenatal care without known occupational exposure to mercury.Methods Mercury concentrations in whole blood were measured by cold vapour atomic absorption spectrophotometry. A dietitian recorded the quantity of seafood consumption among infertile couples via a food-frequency questionnaire. Blood mercury concentrations and quantity of seafood consumption were compared between infertile and fertile couples.Main outcome measures Whole blood mercury concentrations, quantity of seafood consumption.Results Infertile couples had higher blood mercury concentrations than fertile couples. ‘Infertile males with abnormal semen’ and ‘infertile females with unexplained infertility’ also had higher blood mercury concentrations than their fertile counterparts. Blood mercury concentrations were positively correlated with quantity of seafood consumption. Infertile subjects with elevated blood mercury concentrations consumed a larger amount of seafood.Conclusion Higher blood mercury concentration is associated with male and female infertility. Higher seafood consumption is associated with elevated blood mercury concentrations in our infertile population.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A Chinese cultural perspective of nursing care behaviours in an acute setting¶ This study carried out in Hong Kong, identified 29 Chinese patients’ perceptions of the importance of nursing care behaviours in an acute setting using a Chinese language translated version of the CARE-Q instrument. Patients ranked items concerned with ‘giving the patients’ treatments and medication on time’ as the most important and ‘sits down with the patient’ as the least important. Comparisons are made with the results from other cultures and specific Chinese cultural interpretations are drawn to provide direction for nursing care of Chinese patients in Hong Kong and worldwide.
    Type of Medium: Electronic Resource
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