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  • 1
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    Dordrecht : Springer Science+Business Media B.V.
    Keywords: Medicine ; Oncology ; Human Genetics ; Proteomics ; Biomedicine ; Biomedicine general ; Cancer Research ; Human Genetics ; Proteomics ; Springer eBooks
    Pages: : digital
    ISBN: 9789048126750
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  • 2
    Keywords: Biomedical Engineering ; Regenerative Medicine ; Tissue Engineering ; Mechanical engineering ; Biomedical Engineering/Biotechnology ; Biomedical Engineering and Bioengineering ; Regenerative Medicine/Tissue Engineering ; Mechanical engineering ; Springer eBooks
    Description / Table of Contents: Introduction -- Definition, necessity, and prerequisites for modeling 3D tissues and organs -- Prevalent technologies for in vitro tissue/organ biofabrication -- 3D cell printing techniques -- Decellularized extracellular matrix-based bioinks -- Skin -- Blood vessels -- Liver -- Kidney -- Cardiac -- Airway -- Brain -- Muscle -- Conclusion and future perspective
    Abstract: The volume offers a fundamental knowledgein modeling in vitro tissues/organs as an alternative to 2D cell culture and animal testing. Prior to engineering in vitro tissues/organs,the descriptions of prerequisites (from pre-processing to post-processing) in modeling in vitro tissues/organs are discussed. The most prevalent technologies that have been widely used for establishing the in vitro tissue/organ models are also described, including transwell, cell spheroids/sheets, organoids, and microfluidic-based chips. In particular, the authors focus on 3D bioprintingin vitro tissue/organ models using tissue-specific bioinks. Several representative bioprinting methods and conventional bioinks are introduced. As a bioink source,decellularized extracellular matrix (dECM) are importantly covered, including decellularization methods, evaluation methods for demonstrating successful decellularization, and material safety. Taken together, the authors delineate various application examples of 3D bioprintedin vitro tissue/organ models especially using dECM bioinks. This book may provide an introductory guide for modeling in vitro tissues/organs and for opening up agate for beginnersincluding teachers and undergraduate/graduate students. -Provides strategic insight into the biofabrication of in vitro tissues and organs; -Introduces 3D cell-printing techniques and dECM-based bioinks; -Includes examples of 3D cell printed in vitro tissues/organs
    Pages: XV, 114 p. 54 illus., 53 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030322229
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  • 3
    Unknown
    Dordrecht : Springer Science+Business Media B.V.
    Keywords: Medicine ; Oncology ; Human Genetics ; Biomedicine ; Biomedicine general ; Cancer Research ; Human Genetics ; Springer eBooks
    Pages: : digital
    ISBN: 9789400702981
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  • 4
    Keywords: Medicine ; Oncology ; Biotechnology ; Alternative Medicine ; Biomedicine ; Biomedicine general ; Complementary & Alternative Medicine ; Oncology ; Biotechnology ; Popular Science in Medicine and Health ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Preface -- Effect of Dietary Resveratrol in the Treatment of Cancer -- Effect of Flavonoids from Fruits and Vegetables in the Prevention and Treatment of Cancer -- Beneficial Influence of Diets Enriched with Flaxseed and Flaxseed Oil on Cancer -- Cancer Prevention with Green Tea Polyphenols -- Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer -- Association between High Intake of Lycopene-rich Foods and Reduced Risk of Cancer -- Effect of Antioxidant-rich Foods and Supplements on Cancer Risk -- Effect of the Mediterranean Diet on Cancer Reduction -- Modulation of Proteasome Pathways by Nutraceuticals -- Attenuation of Multifocal Cell Survival Signaling by Bioactive Phytochemicals in the Prevention and Therapy of Cancer. Index
    Abstract: Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers.Throughout the past decade, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer
    Pages: : digital.
    ISBN: 9789400764439
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  • 5
    Keywords: Medicine ; Neurosurgery ; Medicine & Public Health ; Neurosurgery ; Springer eBooks
    Pages: : digital
    ISBN: 9784431997030
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  • 6
    Keywords: Life sciences ; Biochemistry ; Bioinformatics ; Biological models ; Biology / Data processing ; Life sciences ; Systems Biology ; Bioinformatics ; Biochemistry, general ; Computer Appl. in Life Sciences ; Springer eBooks
    Description / Table of Contents: Applications in drug discovery -- Aritificial life -- Artificial intelligence and machine learning -- Cancer -- Cell cycle -- Computational microRNA biology -- Functional imaging -- Gene regulatory networks: modeling, reconstruction and analysis -- Large-scale and high-performance computing -- Mathematical theory and methods -- Metabolic networks -- Model databases -- Philosophical and foundational issues -- Quantitative experiment design -- Resources -- Single cell experiments -- Standards, exchange formats, guidelines and ontologies -- Statistical theory and methods -- Structural network analysis -- Systems approaches to translational biomedical research: focus on diagnostic and prognostic applications -- Systems immunology -- Text mining -- Toponomics -- Transcriptional regulation -- Translational control and systems biology
    Abstract: Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. ℗ The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology ́€“ a €˜óne-stop shoṕ€™ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology
    Pages: XLVII, 2367 p. 830 illus., 530 illus. in color. eReference. : online resource.
    ISBN: 9781441998637
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  • 7
    Keywords: Medicine ; Oncology ; Alternative Medicine ; Acupuncture ; Medicine & Public Health ; Complementary & Alternative Medicine ; Acupuncture ; Oncology ; Biomedicine general ; Cancer Research ; Springer eBooks
    Description / Table of Contents: 〈p〉Prelims -- 1℗ An Overview of Acupuncture and Moxibustion for Cancer Care -- 2℗ The Mechanistic Studies of Acupuncture and Moxibustion -- 3℗ Acupuncture for Cancer Pain -- 4℗ Acupuncture for the Treatment of Hot Flashes in Cancer Patients -- 5℗ Acupuncture and Moxibustion for Cancer-related Symptoms -- 6℗ Use of Acupuncture and Moxibustion in the Control of Anticancer Therapy-induced Nausea and Vomiting -- 7 Acupuncture and Moxibustion for Side Effects of Chemotherapy in Cancer Patients -- 8℗ Acupuncture for the Treatment of Symptoms Associated with Radiation Therapy -- 9℗ Quality of Life of Cancer Patients after Acupuncture and Moxibution Treatment -- 10℗ Acupuncture and Moxibustion for Palliative and Supportive Cancer Care -- 11℗ Is Acupuncture or Moxibustion Better Than a Sham or Placebo-treatment?-12℗ Safety and Side Effects of Acupuncture and Moxibustion as a Therapy for Cancer -- 13℗ Acupuncture and Moxibustion in Animal Models of Cancer -- 14℗ Integrating Acupuncture with Western Medicine in Cancer Treatment -- 15℗ Recent Clinical Trials of Acupuncture for Cancer Patients. Index.〈/p〉
    Abstract: 〈p〉Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in narrowing the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, an unparalleled undertaking of a book series is launched to structurally consolidate this area.〈/p〉〈p〉Although acupuncture and moxibustion have been practiced for millennia, they have come under scientific investigation only recently. Acupuncture and moxibustion have been used clinically to treat cancer-related symptoms (e.g. cancer pain, anxiety, depression and insomnia), manage treatment-induced side effects (e.g. hot flashes, nausea and vomiting) and enhance immunity (e.g. blood cell count, lymphocyte and natural killer cell activity). This is the first book manages to provide comprehensive and updated scientific evidence of the effectiveness of acupuncture and moxibustion intervention for cancer care. Laboratory and animal studies have uncovered the mechanisms of acupuncture and moxibustion for cancer therapy. Promising results of most clinical trials show the efficacy and safety of acupuncture and moxibustion in cancer management. This book consists of fifteen chapters which address a range of important aspects that will impact on the application of acupuncture and moxibustion. An overview of the safety and side effects of acupuncture and moxibustion for cancer care are also covered. In addition, the integration of acupuncture with Western medicine in cancer treatment and recent clinical trials are included as well.〈/p〉〈p〉Opinion leaders around the world have teamed up to pursue a thorough and up-to-date review of the area, this volume will contribute great to the cancer, clinical and academic community by providing evidence-based information on the efficacy of acupuncture and moxibustion as an anticancer therapy.〈/p〉〈p〉
    Pages: XI, 354 p. 25 illus., 18 illus. in color. : digital.
    ISBN: 9789400748330
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  • 8
    Keywords: Life sciences ; Human Genetics ; Health Informatics ; Bioinformatics ; Biostatistics ; Life sciences ; Bioinformatics ; Human Genetics ; Biostatistics ; Health Informatics ; Springer eBooks
    Description / Table of Contents: Drug Discovery -- Translational Bioinformatics and Drug Discovery -- Translational Research in Drug Discovery and Development -- Exploring the Potential of Herbal Ligands towards Multidrug Resistant Bacterial Pathogens by Computational Drug Discovery -- The Progress of New Targets of Anti-HIV and Its Inhibitors -- Exploration of Drug Candidates Interacting on Amyloid-β Protofibrils for Alzheimer’s Disease -- Homology Modeling, Structure Based Pharmacophore Modeling, High Throughput Virtual Screening and Docking Studies of L-Type Calcium Channel for Cadmium Toxicity -- Natural Compounds Are Smart Player in Context to Anticancer Potential: An In Silico and In Vitro Advancement -- Genome Wide Association Studies -- A Survey of Bioinformatics Based Tools in RNA-Sequencing (RNA-Seq) Data Analysis -- Epigenetics and Its Role in Human Cancer -- Methods for Microbiome Analysis -- Pharmacogenomics: Clinical Perspective, Strategies and Challenges -- Computational Network Approaches and Their Applications for Complex Diseases -- Bioinformatics Applications in Clinical Microbiology -- Artificial Intelligence and Automatic Image Interpretation in Modern Medicine -- Computation in Medicine: Medical Image Analysis and Visualization
    Abstract: This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics
    Pages: VIII, 437 p. 85 illus., 59 illus. in color. : online resource.
    ISBN: 9789402410457
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  • 9
    Keywords: Medicine ; Oncology ; Alternative Medicine ; Acupuncture ; Biomedicine ; Cancer Research ; Biomedicine general ; Medicine/Public Health, general ; Complementary & Alternative Medicine ; Acupuncture ; Springer eBooks
    Pages: : digital
    ISBN: 9789400705265
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  • 10
    Keywords: Medicine ; Pharmaceutical technology ; Biomedical Engineering ; Diabetes ; Molecular Medicine ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Diabetes ; Springer eBooks
    Description / Table of Contents: Preface -- Chapter 1. Understanding HDL: overview -- 1-1.HDL and disease -- 1-2.HDL functions and clinical applications -- 1-3.HDL composition : apolipoproteins and enzymes -- 1-4.Maturation of HDL -- 1-5.HDL and blood pressure -- Chapter 2. Change of HDL by life style -- 2-1.Exercise and HDL -- 2-2.Smoking and HDL -- 2-3.Elderly’s HDL -- 2-4.HDL depends on body weight -- 2-5.HDL from obese but healthy subject -- 2-6.HDL and apoA-I in smokers’ breast milk -- 2-7.Breast milk from frequent trans fatty acid consumers -- 2-8.HDL in cord blood from small neonates -- Chapter 3. Change of HDL in various diseases -- 3-1.HDL from patients with myocardial infarction -- 3-2.HDL from patients with female angina pectoris -- 3-3.HDL and metabolic syndrome -- 3-4.HDL from male patients with atrial fibrillation -- 3-5.HDL from female patients with atrial fibrillation -- 3-6.HDL from patients with hemorrhagic fever with renal syndrome -- 3-7.HDL from patients with rheumatoid arthritis -- 3-8.HDL and prehypertension -- Chapter 4. Detriment of HDL by pollutant and its evaluation -- 4-1.Particulate matter and HDL -- 4-2.Phthalate and HDL -- 4-3.Cadmium and HDL -- 4-4.Humidifier Sterilizer and HDL -- 4-5.Detection of dysfunctional HDL by microfluidics -- 4-6.Evaluation of dysfunctional HDL using zebrafish embryo -- Chapter 5. Change of HDL by food ingredient -- 5-1.Fructose and apoA-I -- 5-2.Fructose and impairment of HDL functionality -- 5-3.Artificial sweeteners and apoA-I -- 5-4.Artificial sweeteners (aspartame, saccharin) and HDL -- 5-5.Aldoketohexoses and HDL -- 5-6.Iron and HDL -- 5-7.Trans fat and HDL -- 5-8.Salt and HDL 576 p -- Summary and perspectives
    Abstract: This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians
    Pages: XXIV, 383 p. 244 illus. : online resource.
    ISBN: 9789811373879
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