Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Thermal Biology 18 (1993), S. 399-403 
    ISSN: 0306-4565
    Keywords: Bed climate ; body movement ; floor heating ; ondol ; skin temperature
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract To utilize intracellular endoinulinase for inulo-oligosaccharide (IOS) production from inulin, the endoinulinase gene (inu1) of Pseudomonas sp. was successfully cloned into the plasmid pBR322 by using EcoRI restriction endoinulinase and E. coli HB101 as a host strain. The endoinulinase from E. coli HB101/pKMG50 was constitutively expressed, showing similar reaction modes as compared to those of the original strain. However, some critical differences existed in optimal reaction conditions and oligosaccharide compositions between the two products catalyzed by the native enzyme of original strain and those by intact cells from recombinant cells. The IOS compositions produced by recombinant E. coli were quite different due to the diffusional restriction of the substrate and products within the cell wall. Optimal reaction conditions for batchwise production of IOS were as follow : optimum temperature, 55 °C; pH, 7.5; substrate concentration, 100 g/l inulin; enzyme dosage, 20 units/g substrate. Continuous production of IOS from inulin was also carried out at 50 °C using a bioreactor packed with the recombinant cells immobilized on calcium alginate gel. The optimal feed concentration and the feed flow rate were 100 g/l inulin and 0.6 h−1 as a superficial space velocity, respectively. Under the optimum operation conditions, continuous production of IOS was successfully performed with productivity of 166.7 g/l·h for 15 days at 50 °C without significant loss of initial activity.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract In order to increase the synthesis of bovine growth hormone (bGH) using T7 promoter system in E. coli, the artificial AT-rich block was introduced into the upstream region of a consensus Shine-Dalgarno (SD) sequence and the spacer region (between SD and ATG codon) was enriched with A and T nucleotides. The cells harboring pTAJ plasmids with AT-rich block produced bGH in the range of 3% to 25% and the cells harboring pTBJ plasmids with AT-rich sequence in the spacer region from 0.8% to 20% of total cell proteins. This result suggests that AT rich block and AT nucleotides in the spacer region destabilize mRNA secondary structure, depending on the downstream coding information of bGH gene and also, implying that the disruption of mRNA secondary structure might be a major factor for regulating bGH expression in the translational initiation process.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 2218-2219 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The surfaces of rubbed polyimide films for aligning liquid crystal have been studied by atomic force microscopy. The unrubbed films consisted of randomly distributed polyimide clusters of different sizes. On the rubbed surface, however, the clusters are aligned in long chains along the rubbing direction. The cluster chains were separated by about 100 nm for small rubbing strength. For higher strength the cluster chains coalesced into wider ones. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 3006-3008 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We demonstrate a large current power crowbar switch using thyristors without complex snubber circuits. Current sharing was obtained by selecting circuit elements for uniform impedance of parallel switches and varistors were used for voltage sharing between series elements.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1573-2703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Technology
    Notes: Abstract The objective of this paper is to study two-dimensional steady capillary-gravity waves on the interface between two immiscible, inviscid and incompressible fluids of constant but different densities bounded by two horizontal rigid boundaries with small symmetric obstructions of compact support at lower and upper boundaries. The derivation of the forced K-dV equation, which has been extensively studied in the literature for a single-layer fluid, fails for a two-layer fluid when the density ratio of the two-layer fluid is near the square of the depth ratio. By a unified asymptotic method, a forced modified K-dV equation is derived and new types of steady solutions are discovered. Numerical results of various solutions are also presented.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 9 (1997), S. 2804-2806 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This Brief Communication answers an unsettled question pointed out by Peters and Stoker [Commun. Pure Appl. Math 13, 115 (1960)] with regard to a critical case of a two-layer fluid flow with a free surface supported by a horizontal rigid bottom. In the critical case the coefficient of the nonlinear term in the Korteweg–deVries (KdV) equation vanishes and the KdV theory models only a parallel flow. By using higher-order asymptotic expansion, an extended and a modified KdV equation are derived and internal solitary waves and transition waves in the critical case are found. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper we study steady capillary-gravity waves in a two-layer fluid bounded above by a free surface and below by a horizontal rigid boundary with a small obstruction. Two critical speeds for the waves are obtained. Near the smaller critical speed, the derivation of the usual forced KdV equation (FKdV) fails when the coefficient of the nonlinear term in the FKdV vanishes. To overcome this difficulty, a new equation, called a forced extended KdV equation (FEKdV) governing interfacial wave forms, is obtained by a refined asymptotic method. Various solutions and numerical results of this equation are presented. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 12 (2000), S. 3293-3296 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We consider waves at the interface of a two-layer fluid. The upper layer is assumed to be isothermal and compressible with a density profile decreasing exponentially with height up to infinity. The lower layer is assumed to be incompressible with constant density bounded below by a rigid bottom with an obstruction of compact support. By a unified asymptotic method, a stationary forced modified KdV equation is derived when the KdV theory fails. New steady solutions are discovered and numerical results are also presented. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2018-08-02
    Description: AHNAK is known to be a tumor suppressor in breast cancer due to its ability to activate the TGFβ signaling pathway. However, the role of AHNAK in lung tumor development and progression remains unknown. Here, the Ahnak gene was disrupted to determine its effect on lung tumorigenesis and the mechanism by which it triggers lung tumor development was investigated. First, AHNAK protein expression was determined to be decreased in human lung adenocarcinomas compared with matched nonneoplastic lung tissues. Then, Ahnak –/– mice were used to investigate the role of AHNAK in pulmonary tumorigenesis. Ahnak –/– mice showed increased lung volume and thicker alveolar walls with type II pneumocyte hyperplasia. Most importantly, approximately 20% of aged Ahnak –/– mice developed lung tumors, and Ahnak –/– mice were more susceptible to urethane-induced pulmonary carcinogenesis than wild-type mice. Mechanistically, Ahnak deficiency promotes the cell growth of lung epithelial cells by suppressing the TGFβ signaling pathway. In addition, increased numbers of M2-like alveolar macrophages (AM) were observed in Ahnak –/– lungs, and the depletion of AMs in Ahnak –/– lungs alleviated lung hyperplastic lesions, suggesting that M2-like AMs promoted the progression of lung hyperplastic lesions in Ahnak-null mice. Collectively, AHNAK suppresses type II pneumocyte proliferation and inhibits tumor-promoting M2 alternative activation of macrophages in mouse lung tissue. These results suggest that AHNAK functions as a novel tumor suppressor in lung cancer. Implications: The tumor suppressor function of AHNAK, in murine lungs, occurs by suppressing alveolar epithelial cell proliferation and modulating lung microenvironment. Mol Cancer Res; 16(8); 1287–98. ©2018 AACR .
    Print ISSN: 1541-7786
    Electronic ISSN: 1557-3125
    Topics: Medicine
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...