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  • 1
    ISSN: 1573-7217
    Keywords: axillary dissection ; breast cancer ; nodal metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A population-based study was performed to assess the likelihood of axillary lymph node metastases in patients with clinically negative lymph nodes, according to patient age, tumor size and site, estrogen receptor status, histologic type and mode of detection. Data were obtained from the population-based Eindhoven Cancer Registry. During the period 1984–1997, 7680 patients with invasive breast cancer were documented, 6663 of whom underwent axillary dissection. Of the 5125 patients who were known to have clinically negative lymph nodes and underwent axillary dissection, 1748 (34%) had positive lymph nodes at pathological examination. After multivariate analysis, histologic type, tumor size, tumor site and the number of lymph nodes in the axillary specimen remained as independent predictors of the risk of nodal involvement (P 〈 0.001). Lower risks were found for patients with medullary or tubular carcinoma, smaller tumors, a tumor in the medial part of the breast and patients with less than 16 nodes examined. This study gives reliable estimates of the risk of finding positive lymph nodes in patients with a clinically negative axilla. Such information is useful when considering the need for axillary dissection and to predict the risk of a false-negative result when performing sentinel lymph nodebiopsy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7225
    Keywords: Central nervous system tumors ; incidence ; mortality ; Netherlands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Substantial increases in incidence and mortality rates for primary brain tumors have been reported in many, but not all, countries over the past several decades. We analyzed incidence rates for (potential) primary malignant central nervous system (CNS) tumors in an area (southeastern Netherlands) and during a period (1980-94) in which access to healthcare was good and computerized tomography (CT) was available. Methods: Data were obtained from the Eindhoven and Maastricht cancer registries, representing a population of 936,000 and 847,000 inhabitants, respectively. Cases were identified of primary CNS tumors (ICD-0 codes 191, 192, excluding lymphomas) and brain metastases from an unknown primary site (code 199) and data on mortality according to gender and region were provided by Statistics Netherlands. Results: Incidence rates in three-year periods of primary CNS cancer remained stable, also for patients aged 60 years and older. Mortality/incidence ratios ranged from 0.6 to 0.9. Although more CNS cancers were histologically verified in recent years, especially in the Eindhoven region, changes in diagnosis probably did not influence the overall trend of primary CNS cancer. Conclusions: Major changes in the incidence of the most common types of primary CNS cancers (i.e., high-grade astrocytomas) were unlikely in southeastern Netherlands.
    Type of Medium: Electronic Resource
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