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  • 1
    Keywords: Medicine ; Cancer Research ; Human Physiology ; Immunology ; Neurosciences ; Infectious Diseases ; Biomedicine ; Immunology ; Human Physiology ; Neurosciences ; Cancer Research ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response -- Cell Non-Autonomous UPRER Signaling -- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat -- Mitochondria associated membranes and ER stress -- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response -- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling -- ER Protein Quality Control and the Unfolded Protein Response in the Heart
    Abstract: This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike
    Pages: VII, 213 p. : online resource.
    ISBN: 9783319785301
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  35. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2017); 20170111-20170114; Chur, Schweiz; DOC17dav2.4 /20170118/
    Publication Date: 2017-01-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Bestimmung der Subtypen an verschiedenen Personengruppen mit positivem Hepatitis-B-Oberflächenantigen erbrachte folgende Ergebnisse: Unter asymptomatischen Blutspendern (gesunde Träger) wurde der Subtypad bei 20, der Subtypay bei 24 festgestellt. In einer Gruppe symptomatischer Patienten mit akuter Hepatitis B wurdead bei 25 unday bei 29 ermittelt. Patienten einer Anstalt für geistig Behinderte wiesenad in 9 Fällen unday in 23 Fällen auf. Unter den Patienten einer geriatrischen Klinik wurdeay bei 9 Personen festgestellt, desgleichen bei 3 Personen des ärztlichen Personal derselben geriatrischen Klinik. Bei syphilitischen Patienten wurdead in 6 Fällen unday in 29 Fällen ermittelt. Unter den Patienten eines Dialysezentrums fand sichay in 6 Fällen. Diese Ergebnisse zeigen, daß keiner der beiden Subtypen in Belgien wirlich dominiert.
    Notes: Summary Subtyping in various groups of persons positive for hepatitis B surface antigen gave the following results: Among asymptomatic blood donors (healthy carriers) subtypead was found in 20, subtypeay in 24. Among symptomatic patients with acute hepatitis Bad was found in 25,ay in 29. Among patients of an institution for the mentally retardedad was found in 9,ay in 23. Among patients of a geriatric institutionay was found in 9; among medical personnel of the same geriatric institutionay was found in 3 persons. Among symphilis patientsad was found in 6,ay in 29; and in patients of a dialysis centreay was found in 6. These data show that neither subtype is really dominant in Belgium.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-5535
    Keywords: Turbidometry ; Kinetic ; Predictive ; Mathematical model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary An automated tubidimetric instrument (Bioscreen) was used to observe the growth response ofListeria monocytogenes to combinations of temperature (15–30°C), hydrogen-ion (0.1–21.9 μm) (equivalent pH 4.66–7.0) and NaCl concentration (0.5–9.5% w/v). Compared to traditional plate count techniques, the technique allowed many more data points to be captured and replicates to be used, with less expenditure of effort. Optical density curves were filtered (smoothed) to minimize the effect of signal noise and the mean signal from uninoculated wells was subtracted to minimize the effect of signal draft. A novel procedure for fitting growth curves to optical density data has been developed. The procedure involves the use of the logistic function and a calibration equation for fitting, in a single step, in the dimension of optical density. This approach allowed the four parameters of the logistic equation to be derived at each set of experimental conditions. A quadratic response surface was then fitted to the curve parameters using temperature, NaCl and hydrogen-ion concentration as three independent variables. Predicted time to 1000-fold increase in cell numbers compared well to predictions from predictive microbial growth equations generated in other laboratories using traditional plate counting. We propose that this technique should be further evaluated as a method for generating data for modeling the kinetics of microbial growth.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-5535
    Keywords: Yeast ; Zygosaccharomyces ; Spoilage ; Synergism ; pH ; °Brix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A quantitative method for the prediction of growth of the food spoilage yeastZygosaccharomyces bailii in a model fruit-drink system is described. A factorially designed experiment was employed to produce polynomial equations relating pH and sugar concentration (°brix) to the lag period and doubling time of this yeast. Low pH values (<3.0) and high °brix values (>40) show a strong synergistic action on the extension of lag period, which could be used, along with the model presented, in the formulation of product preservation systems.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A mathematical model is developed in state variable form suitable for the study of the control of blood pressure and flow in the mammalian cardiovascular system. The applicability of the model to steady state, both mean and pulsatile, and transient phenomena is demonstrated by the agreement of the results with experimental data. This model was developed to study the neural and renal-endocrine-electrolyte control of cardiovascular functions.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1420-9071
    Keywords: Aeollanthus buchnerianus ; Lamiaceae ; dodecanoic acids ; abietane diterpenes ; antifungal and antibacterial bioactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using bioassay guided isolation, three novel 12 carbon polyoxygenated fatty acids and a novel abietane diterpene have been isolated from the the chloroform extract of aerial parts ofAeollanthus buchnerianus (Lamiaceae). Rigorous spectroscopic methods were used for compound identification. (Z,Z)-8ζ-acetoxy-5ζ-hydroxydodeca-2,6-dienoic acid and (Z,Z)-5ζ,8ζ-dihydroxydodeca-2,6-dienoic acid inhibited the spore germination ofCladosporium cucumerinum (both with Minimum Inhibitory Dose (MID) values of 1 μg) andAspergillus niger (MID 5 and 25 μg respectively). Further, they also reduced the hyphal growth ofPythium ultimum. (Z)-5ζ-hydroxy-6ζ,7ζ,8ζ-triacetoxydodeca-2-dienoic acid exhibited short term inhibition of the growth ofCladosporium cucumerinum. The novel abietane diterpenoid, (rel)-14α-acetoxyabiet-7-en-18-oic acid inhibited the growth of the gram positive bacteriaBacillus subtilis, staphylococcus aureus andStreptomyces scabies (MIC values 80, 20 and 20 μg ml−1 respectively).
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary responses to aerosols of synthetic leukotrienes C and D were examined in two normal volunteers. The leukotrienes were equipotent and equieffective in producing moderate bronchoconstriction accompanied by coughing. Changes in FEV1 were slight, but changes in expiratory flow at low lung volumes were more notable. FPL 55712 abolished the cough response and partially inhibited the bronchoconstriction.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Three methods are evaluated for holding capsules of plastic-embedded tissue for rotary microtomy. Use of a V-block is rapid but deforms the capsule. Gluing the capsule to a supporting block is useful for reorientation of the capsule but otherwise time consuming. A metal adapter is easy to use, does not deform the tissue, and is the preferred method for routine microtomy.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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