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  • 1
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0271-7123
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0920-9964
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Animal Behaviour 6 (1958), S. 245 
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The mouse Bp3 antigen is a variably glycosylated phosphatidylinositol-linked cell surface glycoprotein expressed on early B and T lineage cells, myeloid cells, intestinal epithelial cells, and a discrete population of reticular cells in peripheral lymphoid tissues. The deduced amino acid sequence of Bp3 cDNA shares significant similarity to human and mouse CD38 and molluscan ADP-ribosyl cyclase, enzymes that generate the calcium mobilizing agent cyclic ADP-ribose from NAD. In this study, we cloned and characterized the Bp3 gene. The gene consists of nine exons and spans approximately 27 kilobases. The overall exon organization is very similar to that reported for the ADP-ribosyl cyclase gene in the mollusc Aplysia kurodai. The Bp3 gene is located on mouse chromosome 5 very near the gene for CD38, suggesting that this family arose by gene duplication. The major transcriptional start site of the Bp3 gene in a pro-B cell line (–17 from the ATG start codon) contains a weak initiator sequence. The upstream region lacks a TATA box, but contains consensus recognition sequences for the PU.1, Ikaros/LyF-1, E2A, and TCF-1 transcriptional factors that regulate gene expression in lymphoid and myeloid cells. Consensus motifs for cytokine responsive factors NF-IL6/C-EBP, H-APF-1/APRF, and AP-1 are also present in the flanking region, and interleukin-6 treatment enhances expression of the Bp3 antigen by a myeloblastoid cell line.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2242
    Keywords: Keywords CIMMYT ; ISWYN ; Mega-environments ; Retrospective analysis ; Pattern analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  CIMMYT (the International Maize and Wheat Improvement Center) has routinely conducted international wheat yield trials to study the adaptation of spring bread wheat. The first of these, the International Spring Wheat Yield Nursery (ISWYN), was conducted for 31 years from 1964 to 1994 inclusive (30 cycles were conducted as no nursery was distributed in 1993 because of Karnal Bunt). Recently, pattern analysis methods have been developed and a set of computer programs written, which enable retrospective analyses of such historical databases to appraise the relationships among test environments in a way that discriminates among genotypes. Such an analysis was conducted on the 30 years of yield data from ISWYN and the classification derived from these analyses was compared with an agroecological classification of spring wheat test environments derived by CIMMYT. The incidence of foliar diseases (stem rust, leaf rust, yellow rust, Septoria spp. and Fusarium spp.) was important in the distinction between the high-rainfall low-latitude (mega-environment 2) and the high-input-irrigated low-latitude (mega-environment 1) environment types. The accumulation of resistance genes for these diseases has been an objective of the CIMMYT wheat breeding program. It was hypothesized that, as the relevant resistance genes were successfully pyramided into the germplasm, the distinction between these two mega-environment types would disappear. The results of the retrospective analyses support this hypothesis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2242
    Keywords: Cluster Analysis ; Genotype x environment interaction ; Heritability ; Repeatability ; Structure-recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Several subjective choices must be made when classifying genotypes based on data from plant breeding trials. One choice involves the method used to weight the contribution each environment makes to the classification. A second involves the use of either genotype-means for each environment or genotypevalues for each block, i.e., considering each block to be a different environment. Another involves whether environments (or blocks) in which genotypes are nonsignificantly different should be included or excluded from such classifications. An alternative to the use of raw or standardized data, is proposed in which each environment is weighted by a discrimination index (DI) that is based on the concept of repeatability. In this study the effect of three weighting methods (raw, standardized and DI), the choice of using environments or blocks, and the choice of including or excluding environments or blocks in which genotypic effects were not significant, were considered in factorial combination to give 12 options. A data set comprised of five check cultivars each repeated six times in each of three blocks at six environments was used. The effect of these options on the ability of a hierarchical clustering technique to correctly classify the repeats into five groups, each consisting of all the six repeats of a particular check cultivar, was investigated. It was found that the DI weighting method generally led to better recovery of the known structure. Using block data rather than environmental data also improved structure recovery for each of the three weighting methods. The exclusive use of environments in which genotypic effects were significant decreased structure recovery while the contrary generally occurred for blocks. The best structure recovery was obtained from the DI weighting applied to blocks (whether genotypes were significant or not).
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2242
    Keywords: Sugarcane ; Saccharum spontaneum ; Sugar yield ; Selection history ; Pattern analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An objective of the CSR sugarcane breeding programme in Australia was to assess the scope for broadening the genetic base of the commercial sugarcane germ plasm through interspecific hybridization with Saccharum spontaneum clones. The contribution of both selection history and S. spontaneum to sugar yield and its components was investigated in the germ plasm pool assembled. The analysis was conducted on a data-set of 256 clones, consisting of parents and full-sib families generated from 32 biparental crosses, tested in six environments. The minimum number of generations back to S. spontaneum ancestor in the clone's pedigree was used as a germ plasm score. The geographical origin and selection history of each parent and their use in the biparental crosses were used to develop a selection history score for parents and offspring. The variation for seven attributes, cane yield, commercial cane sugar %, sugar yield, stalk number per stool, stalk weight, fibre % and ash % juice was partitioned according to the germ plasm and selection history scores. Significant (P〈0.05) clone variation and clone x environment interaction for all attributes was present. The germ plasm scores accounted for a significant (P〈0.05) component of the clone variation for all of the attributes except cane yield. There was an increase in sugar yield with an increase in the minimum number of generations back to a S. spontaneum clone. The selection history groups accounted for a high proportion of the variation among parental clones for all of the attributes except cane yield. This suggested that parents were the outcome of strong selection pressure for the commercial cane attributes. However, the selection history groups for the offspring produced by random mating of parents did not account for a high proportion of the variation for the attributes. Using the mixture method of classification we partitioned the 256 clones into five groups for patterns of performance for the seven attributes across the six environments. The five groups emphasized major differences in the patterns of performance for the seven attributes across environments. The distribution of germ plasm and selection history scores in each of the five groups indicated that their patterns of performance were associated with selection history and minimum generations to S. spontaneum. Therefore, both the analysis on selection history and germ plasm scores (extrinsic classification) and the analysis on the mixture method of classification (intrinsic classification) emphasized the influence of selection history on the sugar yield of sugarcane.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2242
    Keywords: Ipomoea batatas ; Sweet potato ; RAPDs ; Molecular markers ; Genetic polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this paper we present a method for the generation of randomly amplified polymorphic DNA (RAPD) markers for sweet potato. These were applied to produce genetic fingerprints of six clonal cultivars and to estimate genetic distances between these cultivars. The level of polymorphism within the species was extremely high. From the 36-decamer random primers used, 170 fragments were amplified, of which 132 (77.6%) were polymorphic. Ten primers resulted in no detected amplification. Of the remaining 26 primers for which amplification was achieved, only one did not reveal polymorphism. Six primers used alone enabled the discrimination of all six genotypes. Pattern analysis, which employed both a classification and ordination method, enabled the grouping of cultivars and the identification of primers which gave greatest discrimination among the cultivars.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 9 (1985), S. 914-920 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'intestin grÊle représente 75% de la longueur du tractus gastro-intestinal, cependant il est rarement le siège d'une formation tumorale. De 1969 à 1983 une revue rétrospective sans sélection des malades observés pendant cette période a permis de retrouver 25 cancers du grÊle ce qui représente 1 cas de cancer par an pour 450,000 personnes. Ces tumeurs malignes siègeaient respectivement au niveau du duodénum, 10 cas; du jéjunum, 6 cas; de l'iléon, 9 cas. Vingt-et-un des malades furent traités par une résection; 17 survécurent à l'intervention (mortalité opératoire: 19%). La survie à 1 an fut de 60%, à 2 ans de 40%, aucun malade ne survécut plus de 5 ans bien que 3 opérés soient actuellement vivants et en bonne santé. Cinq autres malades étaient porteurs d'une tumeur bénigne: 3 adénomes duodénaux et 3 adénomes jéjunaux. Les adénomes duodénaux furent traités par résection endoscopique et les adénomes jéjunaux par résection chirurgicale sans aucune complication.
    Abstract: Resumen El intestino delgado comprende el 75% de la longitud y el 90% de la superficie del tracto gastrointestinal, pero es un lugar infrecuente de neoplasia. Una revisión general y retrospectiva de los patientes de los hospitales de la ciudad de Bristol (Gran Bretaña) entre 1969 y 1983 reveló sólo 25 carcinomas del intestino delgado, lo cual significa una incidencia anual de 1 por 450,000 personas, o sea 0.2 por 100,000, comparada con 51.2/100,000 para carcinoma gástrico y 87.5/100,000 para carcinoma colorrectal en la misma población. La distribución de estos carcinomas señaló 10 duodenales, 6 yeyunales y 9 ileales; 5 pacientes presentaron otras enfermedades asociadas. Veintiuno de los 25 pacientes fueron sometidos a resección quirÚrgica, con 17 sobrevivientes (mortalidad operatoria 19%). La supervivencia fue de 60% a 1 año, y de 40% a 2 años; ningÚn paciente ha sobrevivido 5 años, aunque 3 permanecen vivos y aparentemente libres de recurrencia. Otros 5 pacientes presentaron adenomas benignos: 3 duodenales y 2 yeyunales. Las lesiones duodenales fueron tratadas endoscópicamente, en tanto que los adenomas yeyunales fueron resecados mediante enterotomía. No se presentaron complicaciones como resultado del tratamiento.
    Notes: Abstract The small bowel comprises 75% of the length of the gastrointestinal tract but is a rare site of neoplasia. An unselected retrospective review of Bristol patients between 1969 and 1983 revealed only 25 small bowel carcinomas: an incidence of 1 per 450,000 of population per annum. Distribution was 10 duodenal, 6 jejunal, and 9 ileal carcinomas; 5 patients had other associated diseases. Twenty-one of the 25 patients underwent a surgical resection, of whom 17 survived (operative mortality 19%). Survival was 60% at 1 year and 40% at 2 years; no patient has survived 5 years although 3 remain alive and well. A further 5 patients were found to have benign adenomas in the absence of malignancy: 3 duodenal and 2 jejunal. Duodenal lesions were treated endoscopically while the jejunal adenomas were removed by enterotomy. There were no complications of treatment.
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