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  • 1
    ISSN: 1432-2013
    Keywords: Kidney ; Na+−K+-ATPase ; Sodium Transport ; Volume Expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of renal Na+−K+-ATPase in the acute changes in sodium reabsorption caused by isotonic volume expansion was evaluatedin vivo andin vitro in the rat and the dog. Duringin vivo volume expansion with isotonic saline in the rat, renal medullary Na+−K+-ATPase specific activity increased, while the simultaneously determined cortical Na+−K+-ATPase specific activity and kinetics remained unchanged. Furthermore, experimentsin vitro failed to demonstrate a circulating inhibitor of renal Na+−K+-ATPase both in plasma dialysates from volume-expanded rats and in plasma dialysates concentrated 20-fold by ultrafiltration from volume-expanded dogs. These results suggest that the decreased proximal tubular reabsorption of sodium during volume expansion is not mediated by inhibition of renal cortical Na+−K+-ATPase. The acute increment in medullary Na+−K+-ATPase observed could represent an adaptive response to increased sodium reabsorption by the loops of Henle, and raises the possibility that this enzyme may participate in relatively rapid adjustments in the transport of sodium by the renal tubule.
    Type of Medium: Electronic Resource
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