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  • 1
    Publication Date: 2018-06-14
    Description: Immunome differences between porcine ileal and jejunal Peyer’s patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues Immunome differences between porcine ileal and jejunal Peyer’s patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues, Published online: 13 June 2018; doi:10.1038/s41598-018-27019-7 Immunome differences between porcine ileal and jejunal Peyer’s patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 2
    ISSN: 1572-879X
    Keywords: methane oxidative coupling ; hydrogen peroxide ; gas-phase initiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Methane oxidative coupling in the presence of the catalyst 1% Au/5% La2O3/CaO and gas-phase initiator hydrogen peroxide at the temperature 700–800°C under normal pressure has been studied. It has been shown that hydrogen peroxide remarkably increases the yield of C2+ products without the loss of selectivity. The maximal yield of C2+ products under the conditions studied was 27% with the formation of a noticeable quantity of benzene. It has been proposed, that the observed effect is due to hydroxyl radical formation from hydrogen peroxide, which could be essential under definite conditions also in a conventional catalytic methane oxidative coupling.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The crystal and molecular structures of three derivatives of [(η 5-C5H4Me)Fe(CO)(L)I] [L=2,6-Me2C6H3NC, P(OMe)3, and P(C6H11)3] have been determined. [(η 5-C5H4Me)Fe(CO)(CNC6H3Me2-2,6)I] (1): Space groupP¯1,Z=2,a=13.193(7),b=8.183(5),c=7.465(4) Å,α=95.13(5),β=94.39(5), γ=91.09(5)°. [(η 5-C5H4Me)Fe(CO)[P(OMe)3]I] (2): Space groupP21/c,Z=4,a=7.296(3),b=24.471(6),c=8.877(3) Å,β=111.92(4)°. [(η 5-C5H4Me)Fe(CO)[P(C6H11)3]I] (3): Space groupP21/c,Z=4,a=9.809(3),b=14.147(2),c=8.276(3) Å,β=103.07(2)°. The structures were refined toR values of 0.045, 0.070, and 0.061, respectively. Disorder was observed in the P(OMe)3 ligands on2. Structural data for1 and3 reveal (i) a small movement of the Fe atom away from the ringC atom containing the methyl group, (ii) a larger movement of ring C atoms away from the ring least-squares plane for3 than for1, and (iii) a shift toward an allyl-ene bond length variation in the ring distances for3. Molecular mechanics calculations performed on2 produce a low-energy conformation similar to that found in the crystal structure determination of2 with an energy barrier to ring rotation of ±5 kcal mol−1. A correlation of the structural and molecular mechanics data with the nmr spectra of complexes1 to3 indicates that the steric influence ofL on the ring rotation could be due to ring distortion and/or interaction with the ring methyl group.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-8862
    Keywords: Metal carbonyl dimer ; heterobimetallic dimer ; review ; metalmetal bonding ; MnRe(CO)10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract A review of the chemical and physical properties of MnRe(CO)10 and its derivatives has been undertaken. This heterobimetallic complex is one of the simplest complexes known which contains a bond between two different metals and does not contain bridging groups. The review has revealed that high yield synthetic strategies are known for this complex and the synthetic strategies have bearing for the synthesis of other bimetallic complexes. Kinetic data suggest that information available on monometallic fragments can provide information on the reactivity trends expected for the dimer. However, the second metal is not a neutral spectator and provides a site forsecondary reactions eg for CO substitution. Data on the physical properties of the dimer are sparse and definitive statements ond Mn-Re·v Mn-Re, ΔHMn-Re etc. cannot be made. This has significant implications for studies on related simple and complex dimer and cluster complexes.
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  • 5
    ISSN: 1432-1041
    Keywords: Key words Grapefruit juice ; Quinine ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. Methods: The study was carried out in ten healthy volunteers using a randomised cross-over design. Subjects were studied on three occasions, with a washout period of 2 weeks. During each period, subjects received a pretreatment of 200 ml orange juice (control), full-strength grapefruit juice or half-strength grapefruit juice twice daily for 5 days. On day 6, the subjects were given a single oral dose of 600 mg quinine sulphate with 200 ml of one of the juices. Plasma and urine samples for measurement of quinine and its major metabolite, 3-hydroxyquinine, were collected over a 48-h period and analysed by means of a high-performance liquid chromatography method. Results: The intake of grapefruit juice did not significantly alter the oral pharmacokinetics of quinine. There were no significant differences among the three treatment periods with regard to pharmacokinetic parameters of quinine, including the peak plasma drug concentration (Cmax), the time to reach Cmax (tmax), the terminal elimination half-life (t1/2), the area under the concentration–time curve and the apparent oral clearance. The pharmacokinetics of the 3-hydroxyquinine metabolite were slightly changed when volunteers received grapefruit juice. The mean Cmax of the metabolite (0.25 ± 0.09 mg l−1, mean ± SD) while subjects received full-strength grapefruit juice was significantly less than during the control period (0.31 ± 0.06 mg l−1, P 〈 0.05) and during the intake of half-strength grapefruit juice (0.31 ± 0.07 mg l−1, P 〈 0.05). Conclusion: These results suggest that there is no significant interaction between the parent compound quinine and grapefruit juice, so it is not necessary to advise patients against ingesting grapefruit juice at the same time that they take quinine. Since quinine is a low clearance drug with a relatively high oral bioavailability, and is primarily metabolised by human liver CYP3A4, the lack of effect of grapefruit juice on quinine pharmacokinetics supports the view that the site of CYP inhibition by grapefruit juice is mainly in the gut.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0983
    Keywords: Key words Wheat ; Tissue culture ; Mitochondrial DNA ; rps13 gene ; Co-transcription ; RNA editing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Northern analyses and reverse transcription-polymerase chain-reaction (RT-PCR) experiments, followed by PCR amplification product sequencing, were performed on total mitochondrial (mt) RNAs from wheat seedlings and tissue cultures. It was shown that the rps13 gene, which encodes ribosomal protein S13, and the atp6 gene, which encodes subunit 6 of the ATP synthase complex, were co-transcribed. However, rps13 transcripts were virtually undetectable in seedlings under conditions where atp6 transcripts appeared abundant. In addition, markedly higher steady state transcript levels were observed in tissue culture. Expression of the mitochondrial rps13 gene was confirmed by showing that its transcripts were edited. Slight differences between editing patterns of tissue-culture and whole-plant transcripts were found. Taken together, these results suggest that in vitro culture could disturb the post-transcriptional regulation of gene expression.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1041
    Keywords: Key words Polynesian ; CYP2D6 ; CYP2C19
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Genetic oxidation polymorphisms of debrisoquine (CYP2D6) and proguanil (CYP2C19) were studied in unrelated healthy South Pacific Polynesian volunteers recruited in the South Island of New Zealand. Methods: Phenotyping for CYP2D6 and CYP2C19 activities was determined using debrisoquine and proguanil, respectively, as probe drugs by measuring the urinary metabolic ratio of parent drug and its␣metabolite. Results: Of 100 Polynesian subjects phenotyped, the metabolic ratio of debrisoquine ranged from 0.01 to 9.94. Therefore, all South Pacific Polynesians were classified as extensive metabolizers of debrisoquine according to previously established criteria of the antimode. The prevalence of poor metabolizers of debrisoquine (CYP2D6) in this Polynesian population is 0% (95% confidence interval of 0–3.6%). Oxidation polymorphism of CYP2C19 using proguanil as a probe was also studied in 59 Polynesian volunteers. The frequency distribution of the proguanil/cycloguanil ratio was bimodal. The proguanil/cycloguanil ratios for these subjects ranged from 0.09 to 34.4. Using a recommended proguanil/cycloguanil ratio cut-off point of 10 established in Caucasian populations, eight Polynesian subjects were identified as poor metabolizers of proguanil (CYP2C19), which corresponds to a poor metabolizer phenotype frequency of 13.6% (a 95% confidence interval of 5.9–24.6%). Conclusion: The incidence of poor metabolizer phenotypes for debrisoquine (CYP2D6) in South Pacific Polynesians appears to lower than in Caucasian populations, while the prevalence of poor metabolizers for proguanil (CYP2C19) in this ethnic population is higher. The frequencies of the poor metabolizer phenotype for debrisoquine and also for proguanil in South Pacific Polynesians are similar to those reported in Asian populations.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 998-1005 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Deexcitation electron spectra of core-excited NO have been measured at several excitation energies in the N 1s→2π and O 1s→2π resonances. The nitrogen spectra exhibit significant variation with excitation energy; the oxygen spectra vary only slightly. Sensitivity to excitation energy occurs because each resonance represents the overlap of three transitions to 2Σ+, 2Δ, and 2Σ− states, and each of these excited states decays to a unique set of levels in the final-state ion. We have analyzed all spectra by taking into account excitation energy, lifetime-vibrational interference, and the ordering and splitting of the core-excited levels. Good agreement between calculated line shapes and experiment occurs if it assumed that the level ordering is 2Δ, 2Σ−, 2Σ+ for core-excited nitrogen and 2Σ−, 2Δ, 2Σ+ for core-excited oxygen. Photoexcitation data for oxygen have been analyzed to determine the energies of these states 531.7, 532.7, and 533.7 eV. The deexcitation spectrum from the 2Δ state of nitrogen core-excited NO to the ground state of NO+ has been analyzed using the theory of lifetime-vibrational interference to give a lifetime width for the core-excited state of 146 meV. A similar analysis for the deexcitation of the oxygen core-excited state is less conclusive, but is consistent with a lifetime width of 180 meV.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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