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  • 1
    Unknown
    Stuttgart : Dt. Verl.-Anst.
    Call number: 09-NW:83
    Pages: 320 p.
    ISBN: 3-421-02753-6
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  • 2
    Keywords: Medicine ; Neurosciences ; Otorhinolaryngology ; Medicine & Public Health ; Otorhinolaryngology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Introduction and overview - Karina Cramer and Allison Coffin -- 2. Hair cell development and regeneration - Matthew Kelley and Jennifer Stone -- 3 Tuned for speed: developmental refinement of neural properties for processing with extraordinary temporal precision - R. Michael Burger -- 4.℗ Tuning neuronal ion channels to the auditory environment - Leonard Kaczmarek and Maile Brown -- ℗ 5. Correlates and determinants of critical periods for experienc逓dependent plasticity in the auditory forebrain - Dan Polley -- 6. Excitatory signaling in the developing auditory brainstem - Jason Sanchez and Yong Lu -- 7. ℗ Molecular development in the zebrafish lateral line - Alex Nechiporuk and Teresa Nicolson -- 8. Development of the human auditory system - Lynne Werner -- 9.℗ Plasticity of the avian song system - Sarah Woolley
    Abstract: This volume presents a set of essays that discuss the development and plasticity of the vertebrate auditory system. The topic is one that has been considered before in the Springer Handbook of Auditory Research (volume 9 in 1998, and volume 23 in 2004) but the field has grown substantially and it is appropriate to bring previous material up to date to reflect the wealth of new data and to raise some entirely new topics. At the same time, this volume is also unique in that it is the outgrowth of a symposium honoring two-time SHAR co-editor Professor Edwin W Rubel on his retirement. The focus of this volume, though, is an integrated set of papers that reflect the immense contributions that Dr. Rubel has made to the field over his career.℗ Thus, the volume concurrently presents a topic that is timely for SHAR, but which also honors the pioneer in the field. Each chapter explores development with consideration of plasticity and how it becomes limited over time. The editors have selected authors with professional, and often personal, connections to Dr. Rubel, though all are, in their own rights, outstanding scholars and leaders in their fields. The specific audience will be graduate students, postdoctoral fellows, and established psychologists and neuroscientists who are interested in auditory function, development, and plasticity. This volume will also be of interest to hearing scientists and to the broad neuroscience community because many of the ideas and principles associate with the auditory system are applicable to most sensory systems. The volume is organized to appeal to psychophysicists, neurophysiologists, anatomists, and systems neuroscientists who attend meetings such as those held by the Association for Research in Otolaryngology, the Acoustical Society of America, and the Society for Neuroscience
    Pages: XVIII, 218 p. 52 illus., 36 illus. in color. : online resource.
    ISBN: 9783319215303
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  • 3
    Keywords: Life sciences ; Plant physiology ; Life sciences ; Plant physiology ; Springer eBooks
    Description / Table of Contents: Preface -- I. Diversity and Evolution. 1. Keilin, Cytochrome and its Nomenclature; D.S. Bendall -- 2. When did Hemes enter the Scene of Life? On the Natural History of Heme Cofactors and Heme-Containing Enzymes; A.-L. Ducluzeau, W. Nitschke -- 3. The Diversity of Photosynthetic Cytochromes; E.L.W. Majumder, R.E. Blankenship -- 4. Evolution of Photosynthetic NDH-1: Structure and Physiological Function; T. Shikanai, E.-M. Aro -- II. Theoretical Aspects of Electron Transfer -- 5. Fundamentals of Electron Transfer in Proteins; L.I. Krishtalik -- 6. Theoretical Analysis of Electron Transfer in Proteins, from Simple Proteins to Complex Machineries; G.M. Ullmann et al -- III. Molecular Structures and Functions of Cytochrome Complexes -- A. Photosynthetic Reaction Centers and Linked Cytochromes -- 7. Higher Plant and Cyanobacterial Photosystem I: Connected Cytochrome Pathways; Y. Mazor, N. Nelson -- 8. Cytochrome b559 in Photosystem II; F. M©ơh, A. Zouni -- B. Structure-Function of Cytochrome bc1 and b6f Complexes. 9. Structure-Function of the Cytochrome b6f Lipoprotein Complex; W.A. Cramer, S. Saif Hasan -- 10. Structure-Function Studies of the Cytochrome bc1 Complex of Anoxygenic Photosynthetic Purple Bacteria; L. Esser et al -- 11. Rieske Iron-Sulfur Protein Movement and Conformational Changes in the Cytochrome bc1 ́€“ b6f Complex; L. Huang, E. Berry -- 12. Structural Perspective of Ferredoxin NAD(P)H Reductase Reactions with Cytochrome b6f Complexes; G. Kurisu -- 13. Alternative Rieske Iron-Sulfur Subunits and Small Polypeptides of Cyantobacterial Cytochrome b6f Complexes; M. R©þgner et al -- 14. Inter-Monomer Electron Transfer in Cytochrome bc Complexes; M. Sarewicz et al -- 15. Haem ci or cn 〈of Cytochrome b6f Complex, a Short Retrospective; F. Zito, J. Alric -- C. Cytochrome Oxidases -- 16. Structure and Function of Bacterial Cytochrome c Oxidases; J.A. Lyons et al -- 17. The Respiratory Terminal Oxidases of Cyanobacteria; G. Schmetterer -- 18. XFEL Studies on Bovine Heart Cytochrome c Oxidase; S. Yoshikawa -- 19. Structure and Mechanism of Action of the Alternative Quinol Oxidases; L. Young et al -- IV. Superoxide Generation in Cytochrome bc Complexes -- 20. Mechanisms of Superoxide Generation and Signaling in Cytochrome bc Complexes; D. Baniulis et al -- 21. Electron Transfer Reactions at the Qo Site of the Cytochrome bc1 Complex: the Good, the Bad, and the Ugly; N. Fisher et al -- V. Cytochrome Complexes, Signaling, and Regulation -- 22. Role of the Cytochrome b6f Complex in Regulating Electron Flow and the Dynamics of Photosynthesis; G. Finazzi et al -- 23. A Supercomplex of Cytochrome bf and Photosystem I for Cyclic Electron Flow; J. Minagawa -- 24. State Transition Kinases and Redox Signal Transduction in Chloroplasts; J.-D. Rochaix -- 25. Regulating Synthesis of Cytochromes; S. Zappa, C.E. Bauer -- VI. Assembly of Cytochrome Complexes and Super-Complexes -- 26. Co-Factor Assembly of Cytochrome bc1-b6f Complexes; P. Hamel -- 27. Biogenesis of Cytochrome c Complexes: From Insertion of Redox Cofactors to Assemtly of Different Subunits; B. Khalfaoui-Hassani et al -- 28. Assembly of Transmembrane b-type Cytochromes and Cytochrome Complexes; H.-G. Koch, D. Schneider -- 29. Respiratory Cytochrome Supercomplexes; G. Lenaz, M.L. Genova -- VII. Branched Pathways and Cryptic Cytochromes -- 30. The Interaction between Cytochrome f and Plastocyanin or Cytochrome c6; D.S. Bendall, C.J. Howe -- 31. Cytochrome c6 of Cyanobacteria and Algae: From the Structure to the Interaction; I. D©Ưaz-Moreno et al -- 32. Electron Partitioning in Anoxic Phototrophic Bacteria; M.A. Spero et al -- 33. Cytochrome c6a of Chloroplasts; C.J. Howe et al -- 34. Cryptic c6-like Cytochromes and Cytochrome cm of Cyanobacteria; W. Bialek et al -- 35. Cytochromes and Electron Transfer Pathways of Cyanobacteria; T. Kallas -- Index.℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗
    Abstract: Why study cytochrome complexes? An answer is in the subtitle of the book €œÉvolution, Structures, Energy Transduction, and Signalinǵ€. Studies on the cytochrome family of proteins include and, influence, a wide range of theoretical and computational approaches, as well as a broad cross-section of experimental techniques. Studies of cytochromes and cytochrome complexes thus utilize an extraordinary range of experimental approaches, described in this volume, which include: computational biology, genetics, macromolecular biochemistry, molecular biology, the physics of charge transfer, structure analysis using x-ray and electron diffraction, and ultra-fast spectroscopy. This information and understanding exerts an influence on a wide spectrum of subjects in modern biology, including molecular evolution, mechanisms of membrane-based respiratory and photosynthetic energy transduction, theory of charge transfer in proteins, structure-function of large hetero-oligomeric membrane proteins, including lipid-protein interactions, and trans-membrane signaling. The book starts with a historical introduction that focuses on research in the first half of the 20th century, and the pre-World War II development in England of the field and its notation, proceeding to a discussion of the evolution of cytochromes and hemes, fundamentals of the theory of electron transfer in proteins, and an extensive description of molecular structures of cytochromes and of the cytochrome complexes. The latter information has had a major impact on the broad field of the structure-function of integral membrane proteins, the newest area of macromolecular structural biology. The book includes thorough discussions on cytochrome oxidase including the use of the new non-destructive femtosecond ́€œdiffraction before destructioń€ X-ray free electron laser for diffraction analysis, and major sections on signaling, super-complexes, state transitions, and the interaction of linear and cyclic electron transport chains. The extent of fundamental research areas included in this book makes it an important resource for the teaching of broad aspects of biological energy transduction to advanced undergraduate and graduate students with interests in biology, biochemistry, biological engineering, chemistry, and biophysics
    Pages: XLV, 739 p. 178 illus., 138 illus. in color. : online resource.
    ISBN: 9789401774819
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  • 4
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    Unknown
    Princeton, N.J. : Princeton University Press
    Call number: 09-Q:237
    Keywords: Mathematical Statistics
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  • 5
    Unknown
    New York, NY : Springer
    Keywords: Medicine ; Oncology ; Cytology ; Biomedicine ; Cancer Research ; Cell Biology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: Preface -- Stem Cells and Prostate Development -- Isolation and Characterization of Prostate Stem Cells -- Prostate tumor initiating cells -- TIC Markers and methods of characterization -- Genetic Control of Self Renewal of the TIC -- Therapeutic targeting of the prostate TIC.-℗ The prostate stem cell niche.-℗ Tumor stroma control of the prostate TIC.-℗ Targeting the prostate stem cell for chemoprevention.-℗ Stem cell models for functional validation of prostate cancer genes -- Index́€&#x2039
    Abstract: Recent evidence demonstrates that normal prostate tissue contains stem cells.℗ ℗ There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells.℗ ℗ Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer.℗ ℗ This book will explore℗ the role of stem cells in normal prostate development and prostate cancer, methods for isolation and characterization of normal prostate stem cells and prostate tumor initiating cells, the functional relationship between normal stem cells and prostate tumor initiating cells, the relationship of prostate cancer genetics and self-renewal and differentiation, the prostate stem cell as a target for therapeutics and prevention, and the utility of stem cells for prostate cancer models. ℗ This book synthesizes these concepts and more into a single volume accessible to basic and translational researchers in prostate cancer and beyond
    Pages: : digital.
    ISBN: 9781461464983
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  • 6
    Unknown
    New York : John Wiley
    Call number: H0200:56 ; 05-CHE-60:25
    Keywords: Chemistry, Physical and theoretical / Data processing ; Chemistry, Physical and theoretical / Mathematical models
    Pages: xvii, 542 p.
    ISBN: 0-471-48552-7
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    H0200:56 departmental collection or stack – please contact the library
    05-CHE-60:25 departmental collection or stack – please contact the library
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  • 7
    Keywords: Life sciences ; Mass spectrometry ; Biotechnology ; Microbiology ; Proteomics ; Proteins ; Life sciences ; Protein Science ; Mass spectrometry ; Proteomics ; Applied Microbiology ; Biotechnology ; Springer eBooks
    Description / Table of Contents: Employing 'second generation' matrices -- (MA)LDI MS mass spectrometry imaging at high specificity and sensitivity -- Techniques for fingermark analysis using MALDI MS - a practical overview -- Whole/Intact Cell MALDI MS Biotyping in Mammalian Cell Analyis -- MALDI biotyping for microorganism identification in clinical microbiology -- Future applications of MALDI-TOF MS in microbiology -- MALDESI: Fundamentals, direct analysis, and MS imaging -- Microprobe MS Imaging of Live Tissues, Cells, and Bacterial Colonies using LAESI -- Efficient production of multiply charged MALDI ions -- Food Authentication by MALDI MS - MALDI-TOF MS Analysis of Fish Species -- Quantitative MALDI MS using Ionic Liquid Matrices -- Disease profiling by MALDI MS analysis of biofluids -- Ionic Liquids and other liquid matrices for sensitive MALDI MS analysis -- Coupling liquid MALDI MS to liquid chromatography
    Abstract: This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation; large-scale, high-speed MS sample profiling; new methods based on ℗ MALDI or MALDI-like sample preparations; and the advantages of MALDI MS analysis over ESI (electrospray ionization).℗ This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: ́€Ø Showcases new techniques and applications in MALDI MS ́€Ø Demonstrates how MALDI is preferable to ESI ́€Ø Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and℗ various application areas, such as cancer proteomics
    Pages: XI, 286 p. 80 illus., 56 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319048192
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  • 8
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 216 (1963), S. 231-245 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Im Rahmen der pseudoepitheliomatösen Hyperplasie der Haut hat bisher die pseudobasaliomatöse Hyperplasie wenig Beachtung gefunden. Nach Besprechung der Literatur werden drei eigene einschlägige Beobachtungen (Typ des oberflächlichen, multizentrischen Basalioms, basaliomatöse filiforme Reteleisten und haarkeimartige Veränderungen) bei Histiocytomen ausführlich beschrieben. Diesen Veränderungen kommt für die Beurteilung der Wechselwirkung zwischen Epithel und Mesenchym bei der Entstehung epithelialer Tumoren Bedeutung zu. Ferner ist die pseudobasaliomatöse Epithelhyperplasie im Zusammenhang mit der Pinkusschen Theorie der Basaliomgenese (induktive Wirkung des Mesenchyms) von Interesse. Der Nachweis stark metachromatischer Substanzen im periepithelialen Bindegewebe gibt unter Berücksichtigung der Ergebnisse eigener Untersuchungen über Epithelveränderungen bei 80 Histiocytomen zu der Vermutung Anlaß, daß diese Substanzen der Ausdruck eines „Mesenchymfaktors” sein könnten, der diese eigenartigen Epithelproliferationen auslöst.
    Type of Medium: Electronic Resource
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